Christopher K. Macgowan
University of Toronto
Imaging phantomInternal medicineRadiologyPathologyMagnetic resonance imagingUltrasoundBlood flowCardiologyFetusHemodynamicsPlacentaUmbilical arteryPregnancyFetal circulationHeart diseaseNuclear medicineAnesthesiaGestationAngiologyMedicine
148Publications
25H-index
1,925Citations
Publications 155
Newest
#1Steven K. S. Cho (U of T: University of Toronto)H-Index: 2
#2Jack R. T. Darby (UniSA: University of South Australia)H-Index: 11
Last. Janna L. Morrison (UniSA: University of South Australia)H-Index: 43
view all 9 authors...
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#1Grace M. McBride (UniSA: University of South Australia)H-Index: 1
#2Ashley S. Meakin (UniSA: University of South Australia)
Last. Christopher K. Macgowan (U of T: University of Toronto)H-Index: 25
view all 14 authors...
Abstract null null Purpose null Ten percent of pregnancies are affected by intrauterine growth restriction (IUGR), and evidence suggests that affected neonates have reduced activity of hepatic cytochrome P450 (CYP) drug metabolising enzymes. Given that almost all pregnant individuals take medications and additional medications are often required during an IUGR pregnancy, we aimed to determine the impact of IUGR on hepatic CYP activity in sheep fetuses and pregnant ewes. null null null Methods nu...
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#1Jiaqi Ren (UniSA: University of South Australia)H-Index: 2
#2Jack R. T. Darby (UniSA: University of South Australia)H-Index: 11
Last. Christopher K. MacgowanH-Index: 25
view all 12 authors...
Key points null Maternal undernutrition during gestation alters fetal lung development by impacting surfactant maturation. However, the direction of change remains controversial. We examined the effects of maternal late gestation maternal undernutrition (LGUN) on maternal and fetal outcomes, signaling pathways involved in fetal lung development, pulmonary hemodynamics and oxygen delivery in sheep using a combination of molecular and MRI techniques. LGUN decreased fetal plasma glucose concentrati...
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#1Catherine G. Dimasi (UniSA: University of South Australia)
#2Joanna Lazniewska (UniSA: University of South Australia)H-Index: 14
Last. Mike Seed (U of T: University of Toronto)H-Index: 25
view all 13 authors...
Intrauterine growth restriction (IUGR) is a result of limited substrate supply to the developing fetus in utero, and can be caused by either placental, genetic or environmental factors. Babies born IUGR can have poor long-term health outcomes, including being at higher risk of developing cardiovascular disease. Limited substrate supply in the IUGR fetus not only changes the structure of the heart but may also affect metabolism and function of the developing heart. We have utilised two imaging mo...
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#7Emma L. Bradshaw (Group Health Cooperative)H-Index: 2
The ductus arteriosus (DA) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes. The thorough and explicit measurement and visualization of the right and left heart output during this transition has not been previously accomplished. We combined 4D flow MRI (dynamic volumetric blood flow measurements) and T2 relaxometry (oxygen delivery quantification) in surgically instrumented newborn piglets to assess the DA. T...
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#2Jiawei XuH-Index: 2
Last. Christopher K. MacgowanH-Index: 25
view all 8 authors...
Fetal development relies on a complex circulatory network and accurately assessing the flow distribution is important for understanding pathologies and potential therapies. In this paper, we demonstrate a method for volumetric multidimensional imaging of fetal flow with magnetic resonance imaging (MRI). Fetal application of MRI faces several challenges such as small vascular structures, unpredictable motion, and lack of traditional cardiac gating methods. Here, orthogonal multislice stacks are a...
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#1Lindsay S. Cahill (MUN: Memorial University of Newfoundland)H-Index: 3
#2Grace V. Mercer (MUN: Memorial University of Newfoundland)
Last. W. Tony Parks (MSH: Mount Sinai Hospital, Toronto)H-Index: 15
view all 14 authors...
OBJECTIVES: To determine the relationship between blood flow in the fetal descending aorta and discordant umbilical arteries (UAs). METHODS: Pulsed wave Doppler of both UAs and the descending aorta was performed at 4-weekly intervals between 14 and 40 weeks of gestation in 209 pregnant women. In datasets with discordant UAs, a linear mixed effects model was used to determine the categorical relationship between the UA pulsatility index (PI) (high, low and average) and the descending aorta PI. RE...
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#1Liqun Sun (U of T: University of Toronto)H-Index: 7
#2J. F. P. van Amerom (U of T: University of Toronto)H-Index: 1
Last. John Kingdom (U of T: University of Toronto)H-Index: 73
view all 14 authors...
OBJECTIVES To characterize the distribution of blood flow and oxygen transport in human fetuses with congenital heart disease (CHD) subtypes that present with neonatal cyanosis using magnetic resonance imaging (MRI). METHODS Blood flow was measured in the major vessels of 152 late gestation human fetuses with CHD and 40 gestational age-matched normal fetuses using cine phase contrast MRI. Oxygen saturation (SaO2) was measured in the major vessels of 57 fetuses with CHD and 40 controls. RESULTS C...
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Placental vascular abnormalities are associated with a host of pregnancy complications including placenta mediated fetal growth restriction (FGR). Umbilical arterial (UA) Doppler ultrasound velocity waveforms are widely used in the diagnosis of underlying placental vascular abnormalities in pregnancies with suspected FGR, which greatly help prevent stillbirth via ongoing fetal monitoring and timely delivery. However, the sensitivity of UA Doppler diagnosis diminishes late in gestation. Our goal ...
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#1Brahmdeep S. Saini (U of T: University of Toronto)H-Index: 7
#2Jack R. T. Darby (UniSA: University of South Australia)H-Index: 11
Last. Mike Seed (U of T: University of Toronto)H-Index: 25
view all 14 authors...
KEY POINTS Human placental function is evaluated using non-invasive Doppler ultrasound of umbilical and uterine artery pulsatility indices as measures of resistance in placental vascular beds, while measurement of placental oxygen consumption (VO2 ) is only possible during Caesarean delivery. This study shows the feasibility of using magnetic resonance imaging (MRI) in utero to measure blood flow and oxygen content in uterine and umbilical vessels to calculate oxygen delivery to and VO2 by the g...
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