Laurent-Emmanuel Monfoulet
University of Auvergne
Endothelial stem cellInternal medicineBiomedical engineeringPeripheral blood mononuclear cellGene expressionStromal cellAnimal studiesTumor necrosis factor alphaBioavailabilityChemistryMesenchymal stem cellIn vitroImmunologyIn vivoEx vivoInflammationFlavanUmbilical veinPostprandialCurcuminBioactive glassBone tissueMonocyteExtracellularBone tissue engineeringVascular healthTissue engineeredBeneficial effectsPlant foodsProgrammed cell deathFood scienceCalciumIschemiaBioinformaticsPolyphenolMedicineMicroarray analysis techniquesCell adhesionBiologyCell biologyNutrigenomicsPharmacology
27Publications
8H-index
259Citations
Publications 26
Newest
#1Laurent-Emmanuel Monfoulet (University of Auvergne)H-Index: 8
#2Tatjana RuskovskaH-Index: 12
Last. Dragan Milenkovic (University of Auvergne)H-Index: 32
view all 18 authors...
Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from...
Source
#2Caroline BuffièreH-Index: 20
Last. Christine MorandH-Index: 62
view all 13 authors...
Food matrix interactions with polyphenols can affect their bioavailability and as a consequence may modulate their biological effects. The aim of this study was to determine if the matrix and its processing would modulate the bioavailability and the postprandial nutrigenomic response to a dietary inflammatory stress of apple flavan-3-ol monomers. We carried out an acute randomized controlled study in minipigs challenged with a high fat meal (HFM) supplemented with raw fruit, puree, or apple phen...
3 CitationsSource
#2Caroline BuffièreH-Index: 20
Last. Christine MorandH-Index: 62
view all 13 authors...
Source
#1Marina Nikolić (University of Belgrade)H-Index: 13
#2Aleksandra Konic Ristic (University of Belgrade)H-Index: 1
Last. Pedro Mena (University of Parma)H-Index: 37
view all 23 authors...
Purpose The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendatio...
2 CitationsSource
#1Christine Morand (INRA: Institut national de la recherche agronomique)H-Index: 62
#2Nicolas Barber-Chamoux (French Institute of Health and Medical Research)H-Index: 7
Last. Dragan Milenkovic (INRA: Institut national de la recherche agronomique)H-Index: 32
view all 4 authors...
Source
#1Dragan Milenkovic (UC Davis: University of California, Davis)H-Index: 32
#2Wim Vanden Berghe (UGent: Ghent University)H-Index: 56
Last. Malte KelmH-Index: 90
view all 14 authors...
Although vasculo-protective effects of flavan-3-ols are widely accepted today, their impact on endothelial cell functions and molecular mechanisms of action involved is not completely understood. The aim of this study was to characterize the potential endothelium-protective effects of circulating epicatechin metabolites and to define underlying mechanisms of action by an integrated systems biology approach. Reduced leukocyte rolling over vascular endothelium was observed following epicatechin su...
14 CitationsSource
#2Dilek CobanH-Index: 1
Last. Christine MorandH-Index: 62
view all 7 authors...
How plant food bioactives may have benefits for vascular health? The case of curcumin. Bordeaux VIVA Winter School - XXXIII LIAC MEETING
#1Dragan MilenkovicH-Index: 32
#2Véronique Habauzit (French Institute of Health and Medical Research)H-Index: 11
Last. Christine MorandH-Index: 62
view all 11 authors...
Epidemiological studies reported that a high flavanone intake is associated with a reduced risk of cardiovascular diseases (Mink et al, 2007; Cassidy et al, 2012), however clinical evidence is still lacking. We carried out a cross-over RCT on 52 healthy post-menopausal women who have to consumed daily and for 6-month, 340ml of grapefruit juice (providing 212mg naringenin-glycosides) or of an iso-energetic control beverage mimicking the composition of the juice but without naringenin. The aim of ...
1 Citations
#1Irena KrgaH-Index: 6
#2Dominique BayleH-Index: 5
Last. Dragan MilenkovicH-Index: 32
view all 7 authors...
Capacity of curcumin, a polyphenol presenting vasculo-protective properties, to modulate secretion and miRNA and protein profiles of endothelial microparticles. 1. Congres FSEV French Society of Extracellular Vesicules.
#1Laurent-Emmanuel Monfoulet (INRA: Institut national de la recherche agronomique)H-Index: 8
#2Sylvie Mercier (INRA: Institut national de la recherche agronomique)H-Index: 7
Last. Dragan Milenkovic (INRA: Institut national de la recherche agronomique)H-Index: 32
view all 7 authors...
Abstract Curcumin is a phenolic compound that exhibits beneficial properties for cardiometabolic health. We previously showed that curcumin reduced the infiltration of immune cells into the vascular wall and prevented atherosclerosis development in mice. This study aimed to investigate the effect of curcumin on monocyte adhesion and transendothelial migration (TEM) and to decipher the underlying mechanisms of these actions. Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin...
18 CitationsSource