Young Sook Kim
Seoul National University
PharmacyInternal medicineEndocrinologyGlycationMolecular biologySerum albuminChemistryAldose reductaseAdvanced glycation end-productStreptozotocinDiabetic nephropathyMagnolia officinalisFamily medicineBiochemistryDiabetes mellitusTraditional medicineMAPK/ERK pathwaySignal transductionMedicineCell cultureFibronectinBiologyProtein kinase A
40Publications
16H-index
1,031Citations
Publications 36
Newest
#1Yu-Ri LeeH-Index: 8
#2Seung-Hyun JungH-Index: 20
Last. Jin Sook KimH-Index: 35
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Last. 김진숙
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Advanced glycation end products (AGEs) have been implicated in diabetic complications. In this study, the inhibitory effect on AGEs formation of 156 Korean herbal medicines has been evaluated. Among them, 15 Korean herbal medicines were showed to have significant effect (IC50: <10 μg/ml) compared to positive reference, aminoguandine (IC50: 76.47±4.81 μg/ ml). Especially, four herbal medicines, Alnus firma (leaves, IC50: 3.25±0.10 μg/ml), Juncus decipiens (whole plants, IC50: 4.30±0.44 μg/ml), Sm...
#1최소진H-Index: 1
#2Young Sook KimH-Index: 16
Last. Jin Sook KimH-Index: 35
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#1최소진H-Index: 1
#2Young Sook KimH-Index: 16
Last. Jin Sook KimH-Index: 35
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#1최소진H-Index: 1
#2Young Sook KimH-Index: 16
Last. Jin Sook KimH-Index: 35
view all 4 authors...
Last. Joo-Hwan KimH-Index: 7
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#4Joo-Hwan KimH-Index: 7
#1Dong Ho JungH-Index: 13
#2Young Sook KimH-Index: 16
Last. Jin Sook KimH-Index: 35
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: Activation of the receptor for advanced glycation endproducts (RAGE) triggers cellular responses implicated in the pathogenesis of diabetic complications; blockade of RAGE has been shown to inhibit the development of diabetic complications. To develop a screening system to identify novel disruptors of advanced glycation endproducts (AGE)-RAGE binding, we used an AGE-RAGE binding system in RAGE-overexpressing cells; test compounds were screened using this system. To construct human RAGE-overexp...
5 CitationsSource
#1Ki Mo KimH-Index: 15
#2Young Sook KimH-Index: 16
Last. Jin Sook KimH-Index: 35
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Chronic high glucose levels lead to the formation of advanced glycation end-products (AGEs) as well as AGE precursors, such as methylglyoxal (MG) and glyoxal, via non-enzymatic glycation reactions in patients with diabetic mellitus. Glyoxalase 1 (GLO-1) detoxifies reactive dicarbonyls that form AGEs. To investigate the interaction between AGEs and GLO-1 in mesangial cells (MCs) under diabetic conditions, AGE levels and markers of oxidative stress were measured in GLO-1-overexpressing MCs (GLO-1-...
63 CitationsSource
#1Young Sook KimH-Index: 16
#2Nan Hee KimH-Index: 13
Last. Jin Sook KimH-Index: 35
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The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC₅₀ value of 0.95 µM....
15 CitationsSource