Michael J. Tisza
National Institutes of Health
GeneCancerMembrane fluidityGenomeMicrobiomeMetagenomicsRefSeqEcologyHuman viromeCapsidCholesterolViral metagenomicsMetastasisComputer scienceCancer researchGeneticsMotilityComputational biologyEvolutionary biologyGenBankBiology
27Publications
7H-index
394Citations
Publications 21
Newest
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 7
#2Diana V. Pastrana (NIH: National Institutes of Health)H-Index: 30
Last. Christopher B. Buck (NIH: National Institutes of Health)
view all 26 authors...
When scientists hunt for new DNA sequences, sometimes they get a lot more than they bargained for. Such is the case in metagenomic surveys, which analyze not just DNA of a particular organism, but all the DNA in an environment at large. A vexing problem with these surveys is the overwhelming number of DNA sequences detected that are so different from any known microbe that they cannot be classified using traditional approaches. However, some of these “known unknowns” are undoubtedly viral sequen...
36 CitationsSource
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 7
#2Diana V. Pastrana (NIH: National Institutes of Health)H-Index: 30
Last. Christopher B. Buck (NIH: National Institutes of Health)H-Index: 52
view all 26 authors...
4 CitationsSource
#1Ryan Connor (NIH: National Institutes of Health)H-Index: 1
#2Rodney Brister (NIH: National Institutes of Health)H-Index: 1
Last. Ben Busby (NIH: National Institutes of Health)H-Index: 11
view all 38 authors...
A wealth of viral data sits untapped in publicly available metagenomic data sets when it might be extracted to create a usable index for the virological research community. We hypothesized that work of this complexity and scale could be done in a hackathon setting. Ten teams comprised of over 40 participants from six countries, assembled to create a crowd-sourced set of analysis and processing pipelines for a complex biological data set in a three-day event on the San Diego State University camp...
4 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 18 authors...
Adenoviruses, papillomaviruses, parvoviruses and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or repeated acquisition of genes from host cells. We report the discovery of fou...
3 CitationsSource
#1Michael J. TiszaH-Index: 7
#2Hang Yuan (Georgetown University)H-Index: 19
Last. Christopher B. BuckH-Index: 52
view all 4 authors...
ABSTRACT It is generally assumed that individual papillomas (warts) are caused by infection with individual papillomavirus types. Deep sequencing of virions extracted from a canine oral papilloma revealed the presence of canine papillomavirus 1 (CPV1), CPV2, and a novel canine papillomavirus, CPV19. This suggests that papillomas sometimes harbor multiple viral species.
14 CitationsSource
#1Michael J. Tisza (University of Texas Health Science Center at Houston)H-Index: 7
#2Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
Last. Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
view all 7 authors...
// Michael J. Tisza 1, * , Weina Zhao 1, * , Jessie S.R. Fuentes 1, * , Sara Prijic 1 , Xiaoling Chen 1 , Ilya Levental 1 , Jeffrey T. Chang 1, 2 1 Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, USA 2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA * These authors have contributed equally to this work Correspondence to: Ilya Levental, email: ilya...
20 CitationsSource
#1Christopher B. BuckH-Index: 52
Last. Arvind Varsani (UF: University of Florida)H-Index: 63
view all 20 authors...
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billi...
132 CitationsSource
#1Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
#2Sara Prijic (University of Texas Health Science Center at Houston)H-Index: 6
Last. Jeffrey T. ChangH-Index: 41
view all 10 authors...
Despite the high mortality from metastatic cancer, therapeutic targets to prevent metastasis are limited. Efforts to identify genetic aberrations that predispose tumors to metastasis have been mostly unsuccessful. To understand the nature of candidate targets for metastatic disease, we performed an in silico screen to identify drugs that can inhibit a gene expression signature associated with epithelial–mesenchymal transition (EMT). Compounds discovered through this method, including those previ...
54 CitationsSource
#1Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
#2Prijic Sara (University of Texas Health Science Center at Houston)
Last. Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
view all 6 authors...
New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies that can inhibit an epithelial-to-mesenchymal transition (EMT) gene expression profile, a phenotype that is believed to promote metastases. This yielded predictions of drugs that can both promote and inhibit an EMT transcriptional profile. Following up on these predictions, we confirmed experimentally t...
Source
#1Jacek Wierzchos (CSIC: Spanish National Research Council)H-Index: 43
#2Jocelyne DiRuggiero (Johns Hopkins University)H-Index: 31
Last. Carmen Ascaso (CSIC: Spanish National Research Council)H-Index: 49
view all 11 authors...
The Atacama Desert, northern Chile, is one of the driest deserts on Earth and, as such, a natural laboratory to explore the limits of life and the strategies evolved by microorganisms to adapt to extreme environments. Here we report the exceptional adaptation strategies of chlorophototrophic and eukaryotic algae, and chlorophototrophic and prokaryotic cyanobacteria to the hyperarid and extremely high solar radiation conditions occurring in this desert. Our approach combined several microscopy te...
52 CitationsSource