Michael J. Tisza
National Institutes of Health
GeneCancerMembrane fluidityGenomeMicrobiomeMetagenomicsRefSeqHuman viromeCapsidCholesterolViral metagenomicsMetastasisComputer scienceCancer researchDNA sequencingGeneticsDNAMotilityComputational biologyEvolutionary biologyGenBankBiology
25Publications
6H-index
369Citations
Publications 21
Newest
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 6
#2Christopher B. Buck (NIH: National Institutes of Health)H-Index: 51
Despite remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This gap persists, even though many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases, and all of them encompass large amounts of viral sequence data. The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on hum...
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#1Michael J. TiszaH-Index: 6
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 51
view all 5 authors...
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as 'hypothetical protein' or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface wit...
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#2Alejandro R. GenerH-Index: 2
Last. Ben BusbyH-Index: 11
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Viruses represent important test cases for data federation due to their genome size and the rapid increase in sequence data in publicly available databases. However, some consequences of previously decentralized (unfederated) data are lack of consensus or comparisons between feature annotations. Unifying or displaying alternative annotations should be a priority both for communities with robust entry representation and for nascent communities with burgeoning data sources. To this end, during thi...
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#1Michael J. TiszaH-Index: 6
Last. Christopher B. BuckH-Index: 51
view all 2 authors...
Abstract While there have been remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This is despite the fact that many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases and all of them encompass large amounts of viral sequences. The lack of a comprehensive database for human-associated viruses, along with inadequate methods for high-throughput identificat...
1 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 6
Last. Christopher B. BuckH-Index: 51
view all 7 authors...
2 CitationsSource
#1Michael J. TiszaH-Index: 6
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 51
view all 6 authors...
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as hypothetical protein or the equivalent. Cenote-Taker2, a virus discovery and annotation tool available on command line and with a graphical user interface with f...
1 CitationsSource
#1Gherman Uritskiy (Johns Hopkins University)H-Index: 6
#2Michael J. Tisza (Johns Hopkins University)H-Index: 6
Last. Jocelyne DiRuggiero (Johns Hopkins University)H-Index: 31
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Microbial communities play essential roles in the biosphere and understanding the mechanisms underlying their functional adaptations to environmental conditions is critical for predicting their behavior. This aspect of microbiome function has not been well characterized in natural high-salt environments. To address this knowledge gap, and to build a general framework relating the genomic and transcriptomic components in a microbiome, we performed a meta-omic survey of extremophile communities in...
4 CitationsSource
#1Kema Malki (USF: University of South Florida)H-Index: 3
#1Kema Malki (USF: University of South Florida)H-Index: 7
Last. Mya Breitbart (USF: University of South Florida)H-Index: 67
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Aquifers, which are essential underground freshwater reservoirs worldwide, are understudied ecosystems that harbor diverse forms of microbial life. This study investigated the abundance and composition of prokaryotic and viral communities in the outflow of five springs across northern Florida, USA, as a proxy of microbial communities found in one of the most productive aquifers in the world, the Floridan aquifer. The average abundances of virus-like particles and prokaryotic cells were slightly ...
5 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 6
Last. Christopher B. BuckH-Index: 51
view all 18 authors...
Abstract Adenoviruses, papillomaviruses, and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or acquisition of genes from host cells. Here, we report the discovery of a dozen ne...
6 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 6
Last. Christopher B. BuckH-Index: 51
view all 7 authors...
Abstract Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode possible capsid proteins and viral genome-packaging ATPases similar to those of a diverse range of double-stranded DNA (dsDNA) viruses. This supports the inference that at least some polintons are viruses that remain capable of cell-to-cell ...
4 CitationsSource