Xinyan Xu
Fudan University
Survival analysisEpidemiologyCancerInternal medicineRadiologyOncologyGene expressionPropensity score matchingStage (cooking)Lung cancerLungEsophagusBrain metastasisMetastasisNeuroendocrine tumorsAlectinibAdenocarcinomaPopulationNomogramCancer researchProportional hazards modelRadiation therapyMedicine
12Publications
5H-index
34Citations
Publications 14
Newest
#1Di Liu (Fudan University)H-Index: 7
#2Xinyan Xu (Fudan University)H-Index: 5
Last. Min Fan (Fudan University)H-Index: 15
view all 5 authors...
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#1Di Liu (Fudan University)H-Index: 7
#2Junmiao Wen (Fudan University)H-Index: 6
Last. Min Fan (Fudan University)H-Index: 15
view all 7 authors...
Purpose/Objectives: This study investigated the gene expression profile of small cell esophageal carcinoma (SCEC) and compared it with the expression profiles of small cell lung cancer (SCLC) and esophageal adeno/squamous carcinoma (EAC/ESCC).Materials/Methods: All patients with SCEC, SCLC, and EAC/ESCC in the Surveillance, Epidemiology, and End Results (SEER) database 1973-2014 were included. Overall survival (OS) and prognostic analysis were conducted. De novo expression array analysis was per...
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#1Xinyan XuH-Index: 5
#2Di LiuH-Index: 7
Last. Min FanH-Index: 15
view all 5 authors...
Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion occurs in approximately 5% of non-small cell lung cancer (NSCLC) cases. Variants 1 and 3a/b are the most common EML4-ALK variants. Emerging evidence indicates that patients with variant 1 and those with variant 3a/b exhibit differential therapeutic responses. However, the National Comprehensive Cancer Network guidelines have not included the EML4-ALK fusion subtype in treatment decision-making to date...
1 CitationsSource
#1Yu Gu (Fudan University)H-Index: 3
#2Junhua Zhang (Fudan University)H-Index: 7
Last. Min Fan (Fudan University)H-Index: 15
view all 9 authors...
Non-small cell lung cancer (NSCLC) is the most common cancer and the leading cause of cancer-related deaths worldwide. Age at diagnosis of advanced NSCLC is much older, but studies describing the practice patterns for octogenarians with distant metastasis NSCLC are limited. A retrospective, population-based study using national representative data from the Surveillance, Epidemiology, and End Results (SEER) program was conducted to evaluate 34 882 NSCLC patients with extrathoracic metastases from...
6 CitationsSource
#1Junmiao Wen (Fudan University)H-Index: 6
#2Jiayan Chen (Fudan University)H-Index: 7
Last. Zhen Zhang (Fudan University)H-Index: 25
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Background: Significant modifications have been made to the 8th edition of the American Joint Committee on Cancer (AJCC) distant metastases (M) stage classification for metastatic pancreatic neuroendocrine tumors (PanNETs). We aimed to validate this revised classification among metastatic PanNET patients using the Surveillance, Epidemiology, and End Results database. We further sought to evaluate the feasibility of applying this classification to metastatic pancreatic neuroendocrine carcinoma (P...
7 CitationsSource
#1Xinyan Xu (Fudan University)H-Index: 5
#2Lyu Huang (Fudan University)H-Index: 2
Last. Min Fan (Fudan University)H-Index: 15
view all 8 authors...
Background: The purpose of this study is to develop a radiomics approach to predict brain metastasis (BM) for stage III/IV ALK-positive non-small cell lung cancer (NSCLC) patients. Methods: Patients with ALK-positive III/IV NSCLC from 2014 to 2017 were enrolled retrospectively. Their pretreatment thoracic CT images were collected, and the gross tumor volume (GTV) was defined by two experienced radiation oncologists. An in-house feature extraction code-set was performed based on MATLAB 2015b (Mat...
7 CitationsSource
#1Lyu Huang (Fudan University)H-Index: 2
#2Jiayan Chen (Fudan University)H-Index: 7
Last. Min Fan (Fudan University)H-Index: 15
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Abstract Background The purpose of the study was to investigate the potential of a radiomic signature developed in a general non–small-cell lung cancer (NSCLC) cohort for predicting the overall survival of anaplastic lymphoma kinase (ALK)-positive (ALK+) patients with different treatment types. Materials and Methods After test-retest in the Reference Image Database to Evaluate Therapy Response data set, 132 features (intraclass correlation coefficient > 0.9) were selected in the least absolute s...
6 CitationsSource
Source
#1Junmiao Wen (Fudan University)H-Index: 6
#2Donglai Chen (Tongji University)H-Index: 10
Last. Yongbing Chen (Soochow University (Suzhou))H-Index: 19
view all 11 authors...
BACKGROUND: Lower thoracic esophageal cancer (LTEC) with celiac node metastasis and upper thoracic esophageal cancer (UTEC) with supraclavicular node metastasis were previously categorized as M1a diseases. Our study aimed to investigate whether the clinical significance of supraclavicular and celiac lymph node metastasis should be reevaluated in thoracic esophageal cancer. METHODS: A total of 6178 patients with thoracic esophageal cancer were identified from the Surveillance, Epidemiology, and E...
2 CitationsSource
#1Junmiao Wen (Fudan University)H-Index: 6
#2Di Liu (Fudan University)H-Index: 7
Last. Yongbing Chen (Soochow University (Suzhou))H-Index: 19
view all 11 authors...
Purpose/Objective(s): Treatments for superior sulcus non-small cell lung cancer (SS-NSCLC) have evolved, but adequate treatments of T4 disease have not been found. The aim of our study was to evaluate the prognostic factors and optimal treatment strategy for patients with T4 SS-NSCLC. Materials/Methods: We utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973–2015) to identify patients diagnosed with T4 stage SS-NSCLC (according to the 7th edition American Joint Committe...
2 CitationsSource