Yanwei Li
Shanxi Medical University
EndocrinologyTyrosine hydroxylaseNeurologyReceptorNeuroprotectionPars compactaCortex (anatomy)Insulin resistanceMPTPIncretinAgonistInsulinParkinson's diseaseSubstantia nigraHippocampusLiraglutideDopamineIschemiaMedicinePharmacology
9Publications
9H-index
223Citations
Publications 11
Newest
#1Lingyu Zhang (Shanxi Medical University)H-Index: 3
#2Liping Zhang (Shanxi Medical University)H-Index: 3
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 7 authors...
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disease for which there is no cure. In a clinical trial, the glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 has shown good protective effects in PD patients. The hormone glucose-dependent insulinotropic polypeptide (GIP) has also shown protective effects in animal models of PD. OBJECTIVE: We tested DA-CH5, a novel dual GLP-1/GIP receptor agonist. METHODS: DA-CH5 activity was tested on cells expressing GLP-1, GLP-...
12 CitationsSource
#1Jingjing Tai (Shanxi Medical University)H-Index: 1
#2WeiZhen Liu (Shanxi Medical University)H-Index: 8
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 5 authors...
Abstract Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that have anti-diabetic properties show very promising effects in animal models of AD. Glucagon (Gcg) is a hormone and growth-factor, and the Gcg receptor is expressed in the brain. Here we test the effects of a triple receptor agonist (TA), which activates GIP-1, GIP and...
60 CitationsSource
#1Yanwei Li (SYU: Shaoyang University)H-Index: 9
#2Jin-ying Zhao (SYU: Shaoyang University)H-Index: 2
Last. Christian Hölscher (Lancaster University)H-Index: 60
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Alzheimer’s disease and Parkinson’s disease are the two most common, progressive central neurodegenerative diseases affecting the population over the age of 60 years. Apart from treatments that temporarily improve symptoms, there is no medicine currently available to inhibit or reverse the progression of Alzheimer’s disease and Parkinson’s disease. In traditional Chinese medicine, the root of Scutellaria baicalensis Georgi is a classic compatible component in the decoction of herbal medicine use...
28 CitationsSource
#1Yanwei Li (Shanxi Medical University)H-Index: 9
#2WeiZhen Liu (Shanxi Medical University)H-Index: 8
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 4 authors...
Type 2 diabetes mellitus (T2DM) is a risk factor for Parkinson's disease (PD). Therefore, treatment to improve insulin resistance in T2DM may be useful for PD patients. Glucose dependent insulinotropic polypeptide (GIP) is a member of the incretin hormone family that can promote insulin release and improve insulin resistance. Several GIP analogues have been developed as potential treatments for T2DM. We had shown previously that D-Ala2-GIP-glu-PAL, a novel long-acting GIP analogue, can play a ne...
24 CitationsSource
#1Yanwei LiH-Index: 9
#2Lin LiH-Index: 20
Last. Christian HölscherH-Index: 60
view all 3 authors...
Incretin hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Due to their promising action on insulinotropic secretion and improving insulin resistance (IR), incretin-based therapies have become a new class of antidiabetic agents for the treatment of type 2 diabetes mellitus (T2DM). Recently, the links between neurodegenerative diseases and T2DM have been identified in a number of studies, which suggested that shared mechanisms, such as insuli...
15 CitationsSource
#1Yanwei Li (Shanxi Medical University)H-Index: 9
#2Lin Li (Shanxi Medical University)H-Index: 20
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 3 authors...
Central neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are one of the biggest health problems worldwide. Currently, there is no cure for these diseases. The Gardenia jasminoides fruit is a common herbal medicine in traditional Chinese medicine (TCM), and a variety of preparations are used as treatments for central nervous system (CNS) diseases. Pharmacokinetic studies suggest genipin is one of the main effective ingredients of G. jasminoides fruit extr...
13 CitationsSource
#1Yanwei Li (Shanxi Medical University)H-Index: 9
#2WeiZhen Liu (Shanxi Medical University)H-Index: 8
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 4 authors...
Parkinson's disease (PD) is a chronic neurodegenerative disease, and there is no cure for it at present. Recent research has indicated a link between type 2 diabetes mellitus (T2DM) and PD, which suggested that a treatment to improve insulin resistance for T2DM may be useful for PD patients. Glucose-dependent insulinotropic polypeptide (GIP) belongs to the incretin hormone family, which can promote insulin release and improve insulin resistance. Several GIP analogues have been developed as poten...
42 CitationsSource
#1WeiZhen Liu (Shanxi Medical University)H-Index: 8
#2Yanwei Li (Shanxi Medical University)H-Index: 9
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
view all 6 authors...
Abstract Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have shown neuroprotective properties in animal models of neurodegenerative disorders. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in animal models of Parkinson's disease (PD), and a clinical trial in PD patients showed pro...
21 CitationsSource
#1Jin-Ying ZhaoH-Index: 2
#2Yanwei LiH-Index: 9
Last. Lin LiH-Index: 1
view all 3 authors...
Liver iron overload can be found in a number of different chronic liver diseases.Iron is proposed to play a role in promoting hepatic fibrosis by various mechanisms,including iron-catalyzed production of free radical and lipid peroxidation,alteration of essential biomolecules,triggering cell apoptosis and necrosis,and activation and transformation of the hepatic stellate cell into a myofibroblastic cell.Recent evidences demonstrate that the decrease of hepcidin,a 25-amino acid peptide produced b...
3 Citations
#1Lin Li (Ministry of Education)H-Index: 20
#2Yanwei Li (Ministry of Education)H-Index: 9
Last. Christian Hölscher (Ulster University)H-Index: 60
view all 5 authors...
Iron overload induced by brain ischemia has been shown to be involved in neurodegenerative disease. Little is known about the relationship between brain ischemia and ferroportin 1 (FP1). The aims of this study are: (i) to determine whether iron accumulation in the brain is induced by cerebral hypoperfusion; and (ii) to test whether expression of FP1 is influenced by cerebral ischemia. The common carotid arteries (CCA) of rats were ligated bilaterally to induce cerebral ischemia, and the iron con...
12 CitationsSource