Pablo Tamayo
University of California, San Diego
GeneCancerData miningInternal medicineOncologyGene expressionMolecular biologyRNA interferenceGene expression profilingDiseaseMedulloblastomaOncogeneKRASComputer scienceCancer researchGeneticsBioinformaticsComputational biologyMedicineBiologyCell biology
206Publications
73H-index
81.4kCitations
Publications 195
Newest
#1Somayeh Pouyanfard (UCLA: University of California, Los Angeles)
#2Nairika Meshgin (UCSD: University of California, San Diego)H-Index: 2
Last. Tatiana Kisseleva (UCSD: University of California, San Diego)H-Index: 50
view all 11 authors...
With an increasing number of patients with degenerative hepatic diseases such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophages that are capable of phagocytosis and anti-inflammatory activities such as secretion of matrix metalloproteinases (MMPs) provide an attractive cellular therapy approach. Human induced pluripotent stem cells (iPSCs) are capable of efficiently generati...
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#1Sudeep Banerjee (UCSD: University of California, San Diego)H-Index: 6
#2Hyunho Yoon (UCSD: University of California, San Diego)H-Index: 4
Last. Pablo Tamayo (UCSD: University of California, San Diego)H-Index: 73
view all 11 authors...
Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic KIT mutations that are effectively targeted by imatinib (IM), a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST, and adjuvant therapy only delays recurrence in high-risk tumors. We hypothesized that GIST contains cells with primary IM resistance that may represent a reservoir for disease persistence. Here, we report a subpopulation of CD34+KITlow human GIST cells that have intrinsic IM resistance. These cells p...
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#1Rachael MaynardH-Index: 1
#2Brad PooreH-Index: 7
Last. Eric H. Raabe (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 25
view all 14 authors...
Abstract Medulloblastoma is the most common malignant pediatric brain tumor. Tumors having high levels of c-MYC have the worst clinical prognosis, with only a minority of patients surviving. To address this unmet clinical need, we generated a human neural stem cell model of medulloblastoma that recapitulated the most aggressive subtype phenotypically and by mRNA expression profiling. An in silico analysis of these cells identified mTOR inhibitors as potential therapeutic agents. We hypothesized ...
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#1William C. Hahn (Harvard University)H-Index: 138
#2Joel S. Bader (Johns Hopkins University)H-Index: 62
Last. Jonathan S. WeissmanH-Index: 132
view all 125 authors...
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary ...
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#1Mehreen IshfaqH-Index: 1
#2Timothy V. PhamH-Index: 4
Last. Shweta JoshiH-Index: 16
view all 6 authors...
MDSCs are immune cells of myeloid lineage that plays a key role in promoting tumor growth. The expansion of MDSCs in tumor-bearing hosts reduces the efficacy of checkpoint inhibitors and CAR-T therapies, and hence strategies that deplete or block the recruitment of MDSCs have shown benefit in improving responses to immunotherapy in various cancers, including NB. Ibrutinib, an irreversible molecular inhibitor of BTK, has been widely studied in B cell malignancies, and recently, this drug is repur...
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#1Jingting Li (UCSD: University of California, San Diego)H-Index: 17
#2Xiao-Jun Xu (UCSD: University of California, San Diego)H-Index: 62
Last. George L. Sen (UCSD: University of California, San Diego)H-Index: 18
view all 10 authors...
In adult tissue, stem and progenitor cells must tightly regulate the balance between proliferation and differentiation to sustain homeostasis. How this exquisite balance is achieved is an area of active investigation. Here, we show that epidermal genes, including ~30% of induced differentiation genes already contain stalled Pol II at the promoters in epidermal stem and progenitor cells which is then released into productive transcription elongation upon differentiation. Central to this process a...
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#1Jessica M. Rusert (DI: Discovery Institute)H-Index: 10
#2Edwin F. Juarez (UCSD: University of California, San Diego)H-Index: 6
Last. Robert J. Wechsler-Reya (DI: Discovery Institute)H-Index: 52
view all 40 authors...
Medulloblastoma (MB) is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterogeneity, most MB patients receive similar therapies, including surgery, radiation, and intensive chemotherapy. Although these treatments prolong survival, many patients still die from the disease and survivors suffer severe long-term side effects from thera...
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#1Sang Hoon Lee (KU: Korea University)H-Index: 73
#2John Jun (UCSD: University of California, San Diego)H-Index: 1
Last. Stephen B. Howell (UCSD: University of California, San Diego)H-Index: 91
view all 5 authors...
Background/aim R-spondins control WNT signaling and RSPO1 and LGR6, two of its receptors, are uniquely expressed at high levels in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the interrelations between the expression of the RSPOs and LGRs in HGSOC and in the ovarian surface (OSE) and fallopian tube surface epithelium (FTSE) from which HGSOC arises. Materials and methods Analysis of TCGA (HGSOC), CCLE (ovary), and other publicly accessed RNA-Seq data using UC San...
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#1Shuling Ren (UCSD: University of California, San Diego)H-Index: 8
#2Daria A. Gaykalova (Johns Hopkins University)H-Index: 24
Last. Joseph A. Califano (UCSD: University of California, San Diego)H-Index: 92
view all 23 authors...
The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2/E4/E5, as well as association with lack of integration into the host genome. Models of the E2/E4/E5 carcinogenesis show p53 dependent enhanced prolif...
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#1Anshuman PandaH-Index: 8
#2Anupama YadavH-Index: 8
Last. Gyan BhanotH-Index: 48
view all 13 authors...
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