Takamasa Yamamoto
University of California, San Diego
Mouse model of colorectal and intestinal cancerCancerInternal medicineCCR1ChemokinePathologyOncologyCellTransition (genetics)ImmunologyImmunohistochemistryColitisMMP9PeritoneumTumor microenvironmentSurvival rateInflammationVascular endothelial growth factorLungBevacizumabBlockadeSorafenibAfliberceptMetastasisTumor progressionMyeloidSunitinibRamucirumabBone marrowPrimary tumorAngiogenesisMMP2Lymph nodeKRASHT29 CellsGenetic modelProgrammed death 1Pulmonary metastasisCurative resectionAnti angiogenicCancer researchColorectal cancerCarcinogenesisMyeloid-derived Suppressor CellClinical significanceInterleukin 8MedicineCCL15CXC chemokine receptorsBiologyCXCL1
Publications 10
#1Yoshiro Itatani (UCSD: University of California, San Diego)H-Index: 16
#2Takamasa Yamamoto (UCSD: University of California, San Diego)H-Index: 5
Last. Napoleone Ferrara (UC: University of California)
view all 8 authors...
We tested cis-ApcΔ716/Smad4+/− and cis-ApcΔ716/Smad4+/−KrasG12D mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-ApcΔ716/Smad4+/−KrasG12D mice, although highly aggressive, were suppressed by anti-VEGF treatment. We tested the hypothesis that inflammation, a major risk factor and trigger for CRC, may affect responsiveness to anti-VEGF. Chemically induced...
2 CitationsSource
#1Yoshiyuki Kiyasu (Kyoto University)H-Index: 5
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 13 authors...
Abstract Tumor-stromal interaction is implicated in tumor progression. Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. Here, we investigated the role of CCR1 depletion in myeloid cells in two syngeneic colorectal cancer mouse models: MC38, a transplanted tumor model and CMT93, a liver metastasis model. Both cells induced tumor accumulation of CCR...
1 CitationsSource
#1Yoshiro ItataniH-Index: 16
#2Takamasa YamamotoH-Index: 5
Last. Napoleone FerraraH-Index: 179
view all 3 authors...
#1Ryotaro Ogawa (Kyoto University)H-Index: 5
#2Takamasa Yamamoto (Kyoto University)H-Index: 5
Last. Kenji Kawada (Kyoto University)H-Index: 27
view all 11 authors...
Purpose: SMAD4 is a key transcriptional factor of TGFβ signaling and acts as a tumor suppressor in colorectal cancer. In the present study, we explored the immunologic effect of SMAD4 on the tumor microenvironment. Experimental Design: Using 99 clinical specimens and human colorectal cancer cell lines, we investigate the relationship between SMAD4 expression and neutrophil accumulation. We immunohistochemically analyzed expression of SMAD4, CXCL1, CXCL8, CXCR2, and other proteins with clinical s...
21 CitationsSource
#1Ei Miyamoto (Kyoto University)H-Index: 7
#2Toyofumi F. Chen-Yoshikawa (Kyoto University)H-Index: 10
Last. Hiroshi Date (Kyoto University)H-Index: 68
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BACKGROUND AND OBJECTIVES: The inhibition of the programmed death 1 (PD-1)/its ligand 1 (PD-L1) pathway may be associated with clinical responses in colorectal cancer (CRC). We aimed to characterize the transition of PD-1/PD-L1 expression through pulmonary metastasis (PM) and its clinical relevance. METHODS: This study retrospectively reviewed 50 patients who had curative resection of primary CRC and its PM. We evaluated the presence of PD-1+ tumor-infiltrating lymphocytes (TILs) and PD-L1+ tumo...
4 CitationsSource
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 4 authors...
Anti-angiogenic therapy is one of the promising strategies for many types of solid cancers. Bevacizumab (Avastin), a recombinant humanized monoclonal antibody of vascular endothelial growth factor (VEGF) A, was approved for the first time as an anti-angiogenic drug for the treatment of metastatic colorectal cancer (CRC) by the Food and Drug Administration (FDA) in 2004. In addition, the other VEGF pathway inhibitors including small molecule tyrosine kinase inhibitors (sunitinib, sorafenib, and p...
52 CitationsSource
#1Takamasa Yamamoto (Kyoto University)H-Index: 5
#2Kenji Kawada (Kyoto University)H-Index: 10
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 13 authors...
Purpose: We have reported loss of SMAD4 promotes expression of CCL15 from colorectal cancer to recruit CCR1 + myeloid cells through the CCL15-CCR1 axis, which contributes to invasion and liver metastasis. However, the molecular mechanism of lung metastasis is yet to be elucidated. Our purpose is to determine whether similar mechanism is involved in the lung metastasis of colorectal cancer. Experimental Design: In a mouse model, we examined whether SMAD4 could affect the metastatic activity of co...
36 CitationsSource
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 7 authors...
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Although most of the primary CRC can be removed by surgical resection, advanced tumors sometimes show recurrences in distant organs such as the liver, lung, lymph node, bone or peritoneum even after complete resection of the primary tumors. In these advanced and metastatic CRC, it is the tumor-stroma interaction in the tumor microenvironment that often promotes cancer invasion and/or metastasis through chemok...
66 CitationsSource
#1Susumu Inamoto (Kyoto University)H-Index: 12
#2Yoshiro Itatani (Kyoto University)H-Index: 16
Last. Kenji Kawada (Kyoto University)H-Index: 27
view all 10 authors...
Purpose: We previously reported that loss of SMAD4 promotes chemokine CCL15 expression to recruit CCR1 + myeloid cells via the CCL15–CCR1 axis, which facilitates metastasis of colorectal cancer to the liver. The purposes of this study were to investigate whether essentially the same mechanism works in tumor invasion of the primary colorectal cancer and to evaluate the clinical importance of CCL15 expression and CCR1 + cell accumulation. Experimental Design: Using human colorectal cancer cell lin...
56 CitationsSource
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Makoto Mark Taketo (Kyoto University)H-Index: 131
view all 6 authors...