Christian Brand
Memorial Sloan Kettering Cancer Center
PharmacokineticsCancerBiomedical engineeringPathologySmall moleculeChemistryMaterials scienceIn vivoEx vivoPositron emission tomographyBiodistributionImaging agentPARP1ImmunoconjugateCyclopropanePreclinical imagingNuclear medicineCancer researchFluorescence-lifetime imaging microscopyStereochemistryMedicineFluorescence
44Publications
15H-index
649Citations
Publications 40
Newest
#1Paula Demétrio De Souza França (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
#2Susanne Kossatz (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 15
Last. Thomas Reiner (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 39
view all 15 authors...
BACKGROUND Visual inspection and biopsy is the current standard of care for oral cancer diagnosis, but is subject to misinterpretation and consequently to misdiagnosis. Topically applied PARPi-FL is a molecularly specific, fluorescent contrast-based approach that may fulfill the unmet need for a simple, in vivo, non-invasive, cost-effective, point-of-care method for the early diagnosis of oral cancer. Here, we present results from a phase I safety and feasibility study on fluorescent, topically ...
Source
#1Heiko Schöder (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 77
#2Paula Demétrio De Souza França (UNIFESP: Federal University of São Paulo)H-Index: 6
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 17 authors...
PURPOSE: We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with (18)F-PARPi in patients with head and neck cancer. PATIENTS AND METHODS: Eleven patients with newly diagnosed or recurrent oral and oropharyngeal cancer were injected with (18)F-PARPi (331 +/- 42 MBq) and dynamic PET/CT imaging was performed between 0 min and 25 min post-injection. Static PET/CT scans were obtained at 30 min, 60 min and 120 min post injection. ...
12 CitationsSource
#1Susanne Kossatz (TUM: Technische Universität München)H-Index: 15
#2Giacomo Pirovano (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 23 authors...
For oral, oropharyngeal and oesophageal cancer, the early detection of tumours and of residual tumour after surgery are prognostic factors of recurrence rates and patient survival. Here, we report the validation, in animal models and a human, of the use of a previously described fluorescently labelled small-molecule inhibitor of the DNA repair enzyme poly(ADP–ribose) polymerase 1 (PARP1) for the detection of cancers of the oral cavity, pharynx and oesophagus. We show that the fluorescent contras...
21 CitationsSource
#1Christian A. Mason (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
#2Susanne Kossatz (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 15
Last. Thomas ReinerH-Index: 39
view all 10 authors...
: The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMS) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means of monitoring response to immunotherapy. Methods: Female MMTV-PyMT mice were treated with pexidartinib, a colony-stimulating factor 1 receptor (CSF1R) inhibitor, to reduce TAM density. The accumulation of 89Zr-HDL within the tum...
9 CitationsSource
#1Wenbin Zhu (UA: University of Arizona)H-Index: 5
#2Giacomo Pirovano (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
Last. Dongkyun Kang (UA: University of Arizona)H-Index: 12
view all 9 authors...
Disease diagnosis in low-resource settings can be challenging due to the lack of equipment and trained personnel required for histologic analysis. In this paper, we have developed a smartphone-based epifluorescence microscope (SeFM) for imaging fresh tissues at sub-cellular resolution. SeFM provides similar resolution and field of view (FOV) as those used during histologic analysis. The SeFM device achieved the lateral resolution of 0.57 µm and provided microscopy images over a sample area large...
7 CitationsSource
#1Heiko Schöder (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 77
#2Paula Demétrio De Souza França (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
Last. Thomas Reiner (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 39
view all 17 authors...
Purpose. We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with 18F-PARPi in patients with head and neck cancer. Patients and Methods. Eleven patients (age 49 to 86 years) with newly diagnosed or recurrent oral and oropharyngeal cancer were injected intravenously with 18F-PARPi (331 ± 42 MBq) and dynamic PET/CT imaging was performed between 0 min and 25 min post-injection. Static PET/CT scans were obtained at 30 min, 60 min...
3 CitationsSource
#1Giacomo Pirovano (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
#2Sheryl Roberts (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 8
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 8 authors...
Purpose Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring.
8 CitationsSource
#1Wenbin Zhu (UA: University of Arizona)H-Index: 5
#2Giacomo Pirovano (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
Last. Dongkyun Kang (UA: University of Arizona)H-Index: 12
view all 8 authors...
We developed a smartphone-based epifluorescence microscope for fresh tissue imaging. The smartphone microscope optics was optimally designed to achieve similar resolution (0.56 µm) and FOV (520 µm) as the bench 40x microscope, commonly used during the histopathologic analysis. Preliminary images obtained from an excised human pancreatic tissue stained with a rapid staining fluorescence dye (PARPi-FL) clearly visualized individual tumor cells.
Source
#1Sheryl Roberts (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 8
#2Arianna L. Strome (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 13 authors...
Breast cancer is the most common type of malignant growth in women. Early detection of breast cancer, as well as the identification of possible metastatic spread poses a significant challenge because of the structural and genetic heterogeneity that occurs during the progression of the disease. Currently, mammographies, biopsies and MRI scans are the standard of care techniques used for breast cancer diagnosis, all of which have their individual shortfalls, especially when it comes to discriminat...
10 CitationsSource
#1Simone Krebs (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 13
#2Afruja Ahad (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
Last. Wolfgang A. Weber (TUM: Technische Universität München)H-Index: 67
view all 13 authors...
: There remains an urgent need for the noninvasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor functionality. DOTA antibody reporter 1 (DAbR1) comprises a single-chain fragment of the antilanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid (S)-2-(4-acrylamidobenzyl)-DOTA (AABD). The aim of this study was to investigate whether DAbR1 can be e...
19 CitationsSource