Francesca Tosetti
National Cancer Research Institute
Matrix metalloproteinaseCancerCellKinaseChemistryImmunologyIn vivoOxidative stressInflammationTumor progressionProstate cancerAngiogenesisFenretinideProgrammed cell deathCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyCancer cellPharmacology
47Publications
21H-index
1,663Citations
Publications 47
Newest
#2Caterina CamodecaH-Index: 11
Last. Alessandro PoggiH-Index: 57
view all 10 authors...
ABSTRACTHodgkin lymphoma (HL) resistant to conventional therapies is increasing, making of interest the search for new schemes of treatment. Members of the “A Disintegrin And Metalloproteases” (ADAMs) family, mainly ADAM10 or ADAM17, have been proposed as therapeutic targets in solid tumors and some ADAMs inhibitors have been shown to exert antitumor effects. We have previously described an overexpression of ADAM10 in HL, together with increased release of NKG2D ligands (NKG2D-L) and reduced act...
Source
#1Roberta VenèH-Index: 23
#2Francesca TosettiH-Index: 21
Last. Roberto BenelliH-Index: 55
view all 6 authors...
// Roberta Vene 1,2 , Francesca Tosetti 2 , Simona Minghelli 1,2 , Alessandro Poggi 2 , Nicoletta Ferrari 2 and Roberto Benelli 1 1 Immunology Lab, IRCCS AOU San Martino - IST, Genoa, Italy 2 Molecular Oncology and Angiogenesis Lab, IRCCS AOU San Martino - IST, Genoa, Italy Correspondence to: Roberto Benelli, email: // Keywords : EGFR, celecoxib, colon, fibroblast Received : October 01, 2014 Accepted : March 11, 2015 Published : March 29, 2015 Abstract We previously demonstrated that non-toxic d...
Source
#1Roberta VenèH-Index: 23
#2Barbara CardinaliH-Index: 13
Last. Francesca TosettiH-Index: 21
view all 10 authors...
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic triterpenoid bardoxolone (2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester), arsenic trioxide (As2O3), and phenylethyl isothiocyanate (PEITC), while affecting tumor cell viability, induce sustained Ser9 phosphorylation of the multifunctional...
Source
#1Roberta VenèH-Index: 23
#2Barbara CardinaliH-Index: 13
view all 8 authors...
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic triterpenoid bardoxolone (2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester), arsenic trioxide (As2O3), and phenylethyl isothiocyanate (PEITC), while affecting tumor cell viability, induce sustained Ser9 phosphorylation of the multifunctional...
#1Adriana AmaroH-Index: 16
#2Valentina MirisolaH-Index: 14
Last. Ulrich PfefferH-Index: 43
view all 15 authors...
Abstract Despite advances in surgery and radiotherapy of uveal melanoma (UM), many patients develop distant metastases that poorly respond to therapy. Improved therapies for the metastatic disease are therefore urgently needed. Expression of the epidermal growth factor receptor (EGFR), a target of kinase inhibitors and humanised antibodies in use for several cancers, had been reported. Forty-eight human UMs were analysed by expression profiling. Signalling was tested in three EGFR expressing UM ...
Source
#1Stefania Laurent (UniGe: University of Genoa)H-Index: 10
#2Paola QueiroloH-Index: 47
Last. Maria Pia PistilloH-Index: 24
view all 18 authors...
Background CTLA-4 (Cytotoxic T lymphocyte antigen-4) is traditionally known as a negative regulator of T cell activation. The blocking of CTLA-4 using human monoclonal antibodies, such as Ipilimumab, is currently used to relieve CTLA-4-mediated inhibition of anti-tumor immune response in metastatic melanoma. Herein, we have analyzed CTLA-4 expression and Ipilimumab reactivity on melanoma cell lines and tumor tissues from cutaneous melanoma patients. Then, we investigated whether Ipilimumab can t...
Source
#1Roberta VenèH-Index: 23
#2Roberto BenelliH-Index: 55
Last. Nicoletta FerrariH-Index: 30
view all 6 authors...
Despite recent advances in understanding the biological basis of prostate cancer, management of the disease, especially in the phase resistant to androgen ablation, remains a significant challenge. The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention to prevent or eradicate prostate malignancies. In this study, we have used human hormone-resistant prostate cancer cells, DU145 and PC3, as an in vitro model to assess the efficacy...
Source
#1Adriana AlbiniH-Index: 96
#2Francesca TosettiH-Index: 21
Last. William W. Li (Angiogenesis Foundation)H-Index: 22
view all 5 authors...
Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs in an undetectable and asymptomatic state for many years. These lesions do not progress in the absence of angiogenesis or inflammation. Targeting both processes before clinical manifestation can prevent tumour growth and progression. Angioprevention is a chemoprevention approach that interrupts the formation of new blood vessels when tumour cell foci are in an indolent state. Many efficacious chemoprevent...
Source
#1Nicoletta FerrariH-Index: 30
#2Francesca TosettiH-Index: 21
Last. Adriana AlbiniH-Index: 96
view all 7 authors...
Cardiovascular diseases and cancer are the leading causes of death in most countries. These diseases share many common risk factors as well as pathogenetic determinants, and their incidence is related to age in an exponential manner. Furthermore, it has become apparent that several treatments used in therapy or even in prevention of cancer can impair the structural and functional integrity of the cardiovascular system, giving rise to an interdisciplinary field: cardiooncology. However, tumors an...
Source
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.