Francesca Tosetti
National Cancer Research Institute
Matrix metalloproteinaseCancerCellKinaseChemistryImmunologyIn vivoOxidative stressInflammationTumor progressionProstate cancerAngiogenesisFenretinideProgrammed cell deathCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyCancer cellPharmacology
47Publications
21H-index
1,663Citations
Publications 47
Newest
#1Roberta Pece (UniGe: University of Genoa)H-Index: 2
#2Sara Tavella (UniGe: University of Genoa)H-Index: 17
Last. Cristina D'ArrigoH-Index: 19
view all 16 authors...
Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent such shedding in Hodgkin lymphoma (HL). Since tumor tissue architecture deeply influence the outcome of anti-cancer treatments, we set up new three-dimensional (3D) culture systemsto verify whether ADAM10 inhibitors can contribute to, or en...
Source
Enzymes, once considered static molecular machines acting in defined spatial patterns and sites of action, move to different intra- and extracellular locations, changing their function. This topological regulation revealed a close cross-talk between proteases and signaling events involving post-translational modifications, membrane tyrosine kinase receptors and G-protein coupled receptors, motor proteins shuttling cargos in intracellular vesicles, and small-molecule messengers. Here, we highligh...
2 CitationsSource
#1Paola BarboroH-Index: 19
#2Roberto BenelliH-Index: 55
Last. Nicoletta FerrariH-Index: 30
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Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associated with the CRPC phenotype. ASPH is overexpressed in various malignant neoplasms and catalyzes the hydroxylation of aspartyl and asparaginyl residues in the epidermal growth factor (EGF)-like domains of proteins like NOTCH receptors and ligands, enhancing cel...
4 CitationsSource
#2Francesca TosettiH-Index: 21
Last. Alessandro PoggiH-Index: 56
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Both natural and synthetic nanoparticles have been proposed as drug carriers in cancer treatment, since they can increase drug accumulation in target tissues, optimizing the therapeutic effect. As an example, extracellular vesicles (EV), including exosomes (Exo), can become drug vehicles through endogenous or exogenous loading, amplifying the anticancer effects at the tumor site. In turn, synthetic nanoparticles (NP) can carry therapeutic molecules inside their core, improving solubility and sta...
6 CitationsSource
#1Roberta VenèH-Index: 22
#2Delfina CostaH-Index: 11
Last. Roberto BenelliH-Index: 55
view all 18 authors...
Observational/retrospective studies indicate that prostaglandin-endoperoxide synthase-2 (PTGS2) inhibitors could positively affect colorectal cancer (CRC) patients’ survival after diagnosis. To obtain an acceptable cost/benefit balance, the inclusion of PTGS2 inhibitors in the adjuvant setting needs a selective criterion. We quantified the 72 kDa, CRC-associated, glycosylated form of PTGS2 in 100 frozen CRC specimens and evaluated PTGS2 localization by IHC in the same tumors, scoring tumor epith...
2 CitationsSource
#1Alessandro PoggiH-Index: 56
#2Roberto BenelliH-Index: 55
Last. Maria Raffaella ZocchiH-Index: 42
view all 7 authors...
It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals and virus infections. In the gut, their function is much more complex: indeed, they are not precisely organized in lymphoid aggregates, but rather scattered in the epithelium or in the stroma, where they come in contact with a multitude of antigens derived from commensal or pathogenic micro-organisms, beside th...
40 CitationsSource
#1Caterina CamodecaH-Index: 12
#2Elisa Nuti (UniPi: University of Pisa)H-Index: 25
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 7 authors...
: A disintegrin and metalloproteinase (ADAMs) are membrane-bound metalloproteases responsible for the ectodomain shedding of various transmembrane proteins and play important roles in multiple relevant biological processes. Their altered expression is involved in several pathological conditions, and in particular ADAM10 or ADAM17 overexpression is found in various forms of cancer. To better understand how they are regulated in the cellular context, it is useful to visualize the specific ADAMs pa...
6 CitationsSource
#1Francesca TosettiH-Index: 21
#2Roberta VenèH-Index: 22
Last. Maria Raffaella ZocchiH-Index: 42
view all 10 authors...
ABSTRACTShedding of ADAM10 substrates, like TNFα, MICA or CD30, is reported to affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. Soluble forms of these molecules and ADAM10 can be carried and spread in the microenvironment by exosomes released by tumor cells. We reported new ADAM10 inhibitors able to prevent MICA shedding in Hodgkin lymphoma (HL), leading to recognition of HL cells by cytotoxic lymphocytes.In this paper, we show that the mature bioacti...
18 CitationsSource
#2Roberto BenelliH-Index: 55
Last. Nicoletta FerrariH-Index: 30
view all 7 authors...
Abstract Inflammation plays a central role in prostate cancer (PCa) development through significant crosstalk between the COX-2-ErbB family receptor network and androgen receptor (AR)-EGFR signaling pathways. The purpose of this work was to determine the ability of the COX-2 inhibitor Celecoxib to modulate the EGFR-AR signaling pathway in androgen-dependent PCa cells and to provide a rationale for its beneficial use in chemopreventive strategies. Functional studies of Celecoxib activity were per...
23 CitationsSource
#2Delfina CostaH-Index: 11
Last. Alessandro PoggiH-Index: 56
view all 12 authors...
ABSTRACTAmino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability to upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged as an important structure contributing to Vγ9Vδ2 T cells stimulation. It has been demonstrated that the B30.2 domain of BTN3A1 can bind phosphoantigens (PAg) and drive the activation of Vγ9Vδ2 T cells through c...
28 CitationsSource