Alex Gutteridge
GlaxoSmithKline
GeneProteomeAnatomyGenome-wide association studyInduced pluripotent stem cellPhenotypeEmbryonic stem cellCellular differentiationGene expressionArtificial intelligenceTranscriptomeRegulation of gene expressionNeuroscienceChemistryStructural genomicsData scienceDirected differentiationSaccharomyces cerevisiaeDiseaseStem cellSensory Receptor CellsComputer scienceActive siteProtein structureGeneticsBioinformaticsComputational biologyStereochemistryDrug discoveryIdentification (information)BiologySensory systemCell biology
41Publications
24H-index
2,288Citations
Publications 39
Newest
#1Aidan MacNamaraH-Index: 11
#2Nikolina NakicH-Index: 6
Last. Alex GutteridgeH-Index: 24
view all 7 authors...
Genetic evidence of disease association has often been used as a basis for selecting of drug targets for complex common diseases. Likewise, the propagation of genetic evidence through gene or protein interaction networks has been shown to accurately infer novel disease associations at genes for which no direct genetic evidence can be observed. However, an empirical test of the utility of combining these approaches for drug discovery has been lacking. In this study, we examine genetic association...
2 CitationsSource
#1Jie Zheng (UoB: University of Bristol)H-Index: 22
#2Valeriia Haberland (UoB: University of Bristol)H-Index: 8
Last. Tom R. Gaunt (UoB: University of Bristol)H-Index: 68
view all 34 authors...
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the effects of 1,002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 130 (31.5%) were not supported by results of colocalization analyses, suggesting that genetic confound...
61 CitationsSource
#1Sarah M. Keating (California Institute of Technology)H-Index: 19
#2Dagmar Waltemath (University of Greifswald)H-Index: 16
Last. Jeremy Zucker (PNNL: Pacific Northwest National Laboratory)H-Index: 23
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Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edition of the Systems Biology Markup Language (SBML), a format designed for this purpose. A community of modelers and software authors developed SBML Level 3 over the past decade. Its modular form consists of a core suited to representing reaction-based models ...
68 CitationsSource
#1Aidan MacNamaraH-Index: 11
#2Nikolina NakicH-Index: 6
Last. Alex GutteridgeH-Index: 24
view all 7 authors...
It is widely accepted that genetic evidence of disease association acts as a sound basis for the selection of drug targets for complex common diseases and that propagation of genetic evidence through gene or protein interaction networks can accurately infer novel disease associations at genes for which no direct genetic evidence can be observed. However, an empirical test of the utility of combining these beliefs for drug discovery has been lacking. In this study, we examine genetic associations...
Source
#1Bettina Mieth (Technical University of Berlin)H-Index: 2
#2James R.F. Hockley (University of Cambridge)H-Index: 9
Last. Daniel Ziemek (Pfizer)H-Index: 18
view all 7 authors...
In many research areas scientists are interested in clustering objects within small datasets while making use of prior knowledge from large reference datasets. We propose a method to apply the machine learning concept of transfer learning to unsupervised clustering problems and show its effectiveness in the field of single-cell RNA sequencing (scRNA-Seq). The goal of scRNA-Seq experiments is often the definition and cataloguing of cell types from the transcriptional output of individual cells. T...
11 CitationsSource
#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Steven J. BarrettH-Index: 1
Last. Benoit H. DessaillyH-Index: 18
view all 6 authors...
In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. Here, we systematically tested the ability of 12 varied algorithms, based on network propagation, to identify genes that have been targeted by any drug, on gene-disease data from 22 common non-cancerous diseases in OpenTargets. We considered two biolog...
19 CitationsSource
#1Jeremy Schwartzentruber (EMBL-EBI: European Bioinformatics Institute)H-Index: 51
#3Helena Kilpinen (EMBL-EBI: European Bioinformatics Institute)H-Index: 18
Last. Daniel J. Gaffney (Wellcome Trust Sanger Institute)H-Index: 34
view all 19 authors...
Source
#1Jie Zheng (UoB: University of Bristol)H-Index: 22
#2Valeriia Haberland (UoB: University of Bristol)H-Index: 8
Last. Shan Luo (UoB: University of Bristol)H-Index: 7
view all 34 authors...
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 139 (34%) were not supported by results of colocalization analyses, suggesting that genetic confounding may b...
44 CitationsSource
#1James R.F. HockleyH-Index: 9
#2Toni S Taylor (University of Cambridge)H-Index: 2
Last. Ewan St. John Smith (University of Cambridge)H-Index: 24
view all 10 authors...
Objective Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but the diversity and division of function within these neurons is poorly understood. The identification of signalling pathways contributing to visceral sensation is constrained by a paucity of molecular markers. Here we address this by comprehensive transcriptomic...
103 CitationsSource
#1Alexandre J.C. Loucif (Pfizer)H-Index: 8
#2Pierre-Philippe Saintot (Pfizer)H-Index: 4
Last. Alistair Mathie (Medway School of Pharmacy)H-Index: 51
view all 14 authors...
BACKGROUND AND PURPOSE TREK two-pore-domain potassium (K ) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pathophysiological conditions, has been severely hampered by the lack of potent and/or selective activators and inhibitors. In this study, we describe a new, selective opener of TREK channels, GI-530159. EXP...
29 CitationsSource