Flavia Fontana
University of Helsinki
CancerBiophysicsCellNanoparticleNanotechnologyChemistryMaterials sciencePorous siliconDextranImmunotherapyCell membraneDrug deliveryNano-Cancer immunotherapyComputer scienceCancer researchMedicineMicrofluidicsImmune systemCancer cell
50Publications
17H-index
765Citations
Publications 49
Newest
#1Shiqi WangH-Index: 21
#2Flavia FontanaH-Index: 17
Last. Hélder A. SantosH-Index: 149
view all 4 authors...
Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus o...
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#1Flavia FontanaH-Index: 17
Last. Hélder A. SantosH-Index: 149
view all 4 authors...
In vivo models remain a principle screening tool in the drug discovery pipeline. Here, the challenges associated with the need for animal experiments, as well as their impact on research, individual/societal, and economic contexts are discussed. A number of alternatives that, with further development, optimization, and investment, may replace animal experiments are also revised.
2 CitationsSource
#1Hamed Amani (IUMS: Iran University of Medical Sciences)H-Index: 13
#2Mohammad-Ali Shahbazi (Zanjan University of Medical Sciences)H-Index: 30
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
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Abstract Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in the treatment of various diseases. However, owing to the dynamic nature of the immune system, this approach has often been challenged by concerns regarding the lack of adequate long-term responses in patients. The development of microneedles (MNs) has resulted in the improvement and expansion of immuno-reprogramming strategies due to the housing of high accumulation of dendritic cells, macrophage...
13 CitationsSource
The current situation, heavily influenced by the ongoing pandemic, puts vaccines back into the spotlight. However, the conventional and traditional vaccines present disadvantages, particularly related to immunogenicity, stability, and storage of the final product. Often, such products require the maintenance of a "cold chain," impacting the costs, the availability, and the distribution of vaccines. Here, after a recall of the mode of action of vaccines and the types of vaccines currently availab...
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#1Flavia FontanaH-Index: 17
Last. Hélder A. SantosH-Index: 149
view all 4 authors...
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#1Flavia Fontana (UH: University of Helsinki)H-Index: 17
#2Raquel Bártolo (UH: University of Helsinki)H-Index: 1
Last. Hélder A. SantosH-Index: 149
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During the last 20+ years, research into the biomedical application of nanotechnology has helped in reshaping cancer treatment. The clinical use of several passively targeted nanosystems resulted in improved quality of care for patients. However, the therapeutic efficacy of these systems is not superior to the original drugs. Moreover, despite extensive investigations into actively targeted nanocarriers, numerous barriers still remain before their successful clinical translation, including suffi...
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#1Flavia FontanaH-Index: 17
#2Hélder A. SantosH-Index: 149
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#1Patrícia Figueiredo (UH: University of Helsinki)H-Index: 13
#2Anni Lepland (UT: University of Tartu)H-Index: 4
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
view all 12 authors...
Abstract Nanomedicines represent innovative and promising alternative technologies to improve the therapeutic effects of different drugs for cancer ablation. Targeting M2-like tumor-associated macrophages (TAMs) has emerged as a favorable therapeutic approach to fight against cancer through the modulation of the tumor microenvironment. However, the immunomodulatory molecules used for this purpose present side effects upon systemic administration, which limits their clinical translation. Here, th...
5 CitationsSource
#1Ruoyu Cheng (UH: University of Helsinki)H-Index: 12
#2Flavia Fontana (UH: University of Helsinki)H-Index: 17
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
view all 15 authors...
Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as "vacosome") by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidy...
1 CitationsSource
#1Antti Rahikkala (UH: University of Helsinki)H-Index: 9
#2Flavia Fontana (UH: University of Helsinki)H-Index: 17
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 149
view all 12 authors...
Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, long circulation time, and capability to transport cargo all around the body, thus presenting enormous potential in medical applications. In this study, we investigated hybrid nanoparticles consisting of nano-sized autologous or allogeneic red blood cell (RBC) membranes encapsulating porous silicon nanoparticles (PSi NPs). These NPs were functionalized with a model cancer antigen TRP2, which was either exp...
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