Emanuel Della-Torre
Vita-Salute San Raffaele University
Internal medicineSurgeryPathologyCytotoxic T cellAntibodyDermatologyCohort studyImmunologyBiopsyTocilizumabPneumoniaSarilumabDiseaseMEDLINEIgG4-related diseaseFibrosisRituximabAnakinraSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)In patientCancer researchMedicineBiologyGastroenterology
78Publications
27H-index
3,248Citations
Publications 77
Newest
We read with interest the recent report by Geisen et al ,1 who describe the immunogenicity and safety profile of two mRNA-based anti-SARS-CoV-2 vaccines in a cohort of 26 patients with chronic arthritides, psoriasis and other inflammatory diseases, compared with 42 healthy controls. The majority of subjects were health professionals, which makes the 14-day post-vaccinal observations provided by the authors particularly informative for high-risk settings, such as hospitals. Extensive data about t...
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#1Giuseppe A. Ramirez (UniSR: Vita-Salute San Raffaele University)H-Index: 18
#2Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
Last. Mona-Rita Yacoub (UniSR: Vita-Salute San Raffaele University)H-Index: 14
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#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
#2Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
Last. Lorenzo Dagna (UniSR: Vita-Salute San Raffaele University)H-Index: 37
view all 8 authors...
ABSTRACT Background The 2019 ACR/EULAR Classification Criteria for IgG4-related disease (IgG4-RD) represent a fundamental tool for patient enrollment in research studies and in clinical trials but their usefulness in daily clinical practice remains unknown. Objective To validate the 2019 ACR/EULAR Classification Criteria for IgG4-RD in a real-life setting and to anticipate their utility for orienting disease diagnosis and patient management. Methods Four experts were asked to classify 200 patien...
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#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
#2Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
Last. Lorenzo Dagna (UniSR: Vita-Salute San Raffaele University)H-Index: 37
view all 16 authors...
Background. Restraining maladaptive inflammation is considered a rationale strategy to treat severe COVID-19 but available studies with selective inhibitors of pro-inflammatory cytokines have not provided unequivocal evidence of survival advantage. Late administration is commonly regarded as a major cause of treatment failure but the optimal timing for anti-cytokine therapy initiation in COVID-19 patients has never been clearly established. Objectives. To identify a window of therapeutic opportu...
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#1Gaia Mancuso (UniSR: Vita-Salute San Raffaele University)H-Index: 3
#2Tatiana JofraH-Index: 9
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
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#1Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
#2Andreu Fernández-Codina (UWO: University of Western Ontario)H-Index: 10
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
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INTRODUCTION Awareness of IgG4-related disease (IgG4-RD) is increasing worldwide and specialists are now familiar with most of its clinical manifestations and mimickers. IgG4-RD promptly responds to glucocorticoids and repeated courses are typically used to induce and maintain remission because the disease relapses in most patients. If left untreated it can lead to organ dysfunction, organ failure and death. Advancement in our understanding of IgG4-RD pathogenesis is leading to the identificatio...
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#1Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
#2Miriam Sant'Angelo (UniSR: Vita-Salute San Raffaele University)
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
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#1Giulio Cavalli (UniSR: Vita-Salute San Raffaele University)H-Index: 27
#2Alessandro Larcher (UniSR: Vita-Salute San Raffaele University)H-Index: 29
Last. Andrea PoliH-Index: 11
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Background: Patients with severe COVID-19 develop a life-threatening hyperinflammatory response to the virus. Interleukin (IL)-1 or IL-6 inhibitors have been used to treat this patient population, but the comparative effectiveness of these different strategies remains undetermined. We aimed to compare IL-1 and IL-6 inhibition in patients admitted to hospital with COVID-19, respiratory insufficiency, and hyperinflammation. Methods: This cohort study included patients admitted to San Raffaele Hosp...
17 CitationsSource
#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
#2Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
Last. Lorenzo Dagna (UniSR: Vita-Salute San Raffaele University)H-Index: 37
view all 8 authors...
OBJECTIVE Rituximab is increasingly used in IgG4-related disease (IgG4-RD) but high costs limit its wide off-label administration. European and US regulatory agencies have recently approved rituximab biosimilars for the treatment of different rheumatologic and hematological conditions. No data are available, yet, on the efficacy and safety of rituximab biosimilars for the treatment of IgG4-RD. Scope of the present work is to evaluate the efficacy and safety of the rituximab biosimilar CT-P10 (RT...
1 CitationsSource
#1Lucrezia Rovati (UniSR: Vita-Salute San Raffaele University)H-Index: 6
#2Naoki Kaneko (Ragon Institute of MGH, MIT and Harvard)H-Index: 11
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
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OBJECTIVES IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disorder characterized by a dysregulated resolution of inflammation and wound healing response that might develop after an apoptotic insult induced by cytotoxic T lymphocytes (CTLs). Mer receptor tyrosine kinase (MerTK) and its ligand Protein S (ProS1) have a pivotal role in the resolution of inflammation, being implicated in the clearance of apoptotic cells, quenching of the immune response and development of tissue fibr...
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