Tamar Kadar
Israel Institute for Biological Research
Internal medicineEndocrinologySurgeryPathologyHippocampal formationChemistryImmunologyCorneaInflammationCorneal neovascularizationSulfur mustardHippocampusBrain damageToxicityAnesthesiaMorris water navigation taskCentral nervous systemMedicineBiologyPharmacology
93Publications
26H-index
2,012Citations
Publications 92
Newest
#8Yentl Evgy (Israel Institute for Biological Research)H-Index: 4
#9Ohad Shifman (Israel Institute for Biological Research)H-Index: 11
Last. Tamar Sabo (Israel Institute for Biological Research)H-Index: 10
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Mice are normally unaffected by SARS-CoV-2 infection since the virus does not bind effectively to the murine version of the ACE2 receptor molecule. Here we report that induced mild pulmonary morbidities render SARS-CoV-2 refractive CD-1 mice to be susceptible to this virus. Specifically, SARS-CoV-2 infection after application of low-doses of the acute-lung-injury stimulants bleomycin or ricin caused a severe disease in CD-1 mice, manifested by sustained body weight loss and mortality rates of >5...
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#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
view all 8 authors...
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Inbal Egoz (Israel Institute for Biological Research)H-Index: 7
Last. Ariel Gore (Israel Institute for Biological Research)H-Index: 6
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#1Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
#2Maayan Cohen (Israel Institute for Biological Research)H-Index: 10
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
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Abstract Skin decontamination following exposure to chemical agents is a most important component of the individual defense doctrine, removing the agent, ceasing its penetration and preventing secondary contamination of the first responders. The goal of the current study was to compare the efficacy of Reactive Skin Decontaminant Lotion (RSDL) and Fuller's Earth (FE) following exposure to sulfur mustard (SM) and VX, aiming to find the optimal procedure for mass casualty decontamination protocol. ...
1 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
view all 4 authors...
Abstract The use of sulfur mustard (SM) in global terrorism is still a relevant threat to both civilian population and military personnel. Casualties exposed to SM may present mild, moderate or severe acute ocular lesions followed by a complete ocular resolution, chronic lesions or re-emerged ocular pathologies after a latent period. Current treatment for SM-induced ocular injury is based mainly on the clinical manifestation at the different stages of the injury and includes pharmaceutical and s...
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#1Reut Falach (Israel Institute for Biological Research)H-Index: 9
#2Liat Bar-On (Israel Institute for Biological Research)H-Index: 3
Last. Tamar Sabo (Israel Institute for Biological Research)H-Index: 10
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Severe manifestations of COVID-19 are mostly restricted to people with comorbidities. Here we report that induced mild pulmonary morbidities render SARS-CoV-2-refractive CD-1 mice to be susceptible to this virus. Specifically, SARS-CoV-2 infection after application of low-doses of the acute-lung-injury stimulants bleomycin or ricin caused a severe disease in CD-1 mice, manifested by sustained body weight loss and mortality rates of >50%. Further studies revealed markedly higher levels of viral R...
Source
#1Reut Falach (Israel Institute for Biological Research)H-Index: 9
#2Liat Bar-On (Israel Institute for Biological Research)H-Index: 3
Last. Tamar Sabo (Israel Institute for Biological Research)H-Index: 10
view all 29 authors...
Severe manifestations of COVID-19 are mostly restricted to people with comorbidities. Here we report that induced mild pulmonary morbidities render SARS-CoV-2-refractive CD-1 mice to be susceptible to this virus. Specifically, SARS-CoV-2 infection after application of low-doses of the acute-lung-injury stimulants bleomycin or ricin caused a severe disease in CD-1 mice, manifested by sustained body weight loss and mortality rates of >50%. Further studies revealed markedly higher levels of viral R...
Source
#1Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
#2Eliezer Fishbine (Israel Institute for Biological Research)H-Index: 7
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 6 authors...
Sulfur mustard (HD) and VX are potent chemical warfare agents (CWAs) that penetrate rapidly through the skin causing severe acute and prolonged injuries that might result in death. Moreover, several toxic industrial chemicals (TICS) that are being routinely used in the industry and agriculture can be as deadly and damaging. Thus, following percutaneous skin exposure, rapid removal of the toxic agent by decontamination is one of the most crucial components in the individual defense. This can be a...
1 CitationsSource
Last. Tamar KadarH-Index: 26
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Purpose: To further investigate the inflammatory response as one of the leading factors in the development of delayed limbal stem cell deficiency, clinically manifested by corneal neovascularization , following sulfur mustard ocular exposure in rabbits and to evaluate potential therapy. Materials and methods: Right eyes of rabbits were exposed to sulfur mustard vapor. Clinical examination was performed and the growth of corneal blood vessels was evaluated. Inflammatory cells (neutrophils, macrop...
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#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 8 authors...
Abstract Eye exposure to organophosphate (OP) chemical warfare irreversible acetylcholinesterase inhibitors, results in long-term miosis and impaired visual function. In contrast to the well-documented miotic and ciliary muscle spasm observed following chemical warfare, OP ocular exposure, little is known regarding the ocular surface histopathological insult. The aim of the present study was to determine the degree of the ocular surface insult following sarin or VX ocular exposure and to evaluat...
3 CitationsSource