Ichiro Murai
Nihon University
Circadian rhythmInternal medicineEndocrinologyPepsinFetusEndocrine glandCLOCKChemistryPinealectomyMelatoninInsulinSuprachiasmatic nucleusStomachDeformityPineal glandLeptinProstaglandinRachisScoliosisHyperinsulinemiaLesionGastric mucosaRestraint stressWater immersionAnesthesiaSecretionCentral nervous systemPeriod (gene)MedicineBiology
24Publications
13H-index
614Citations
Publications 24
Newest
#1Ichiro Murai (Nihon University)H-Index: 13
#2Junko OyamaH-Index: 1
Last. Kazunori KanazawaH-Index: 1
view all 3 authors...
#1Junko Oyama (Nihon University)H-Index: 1
#2Ichiro Murai (Nihon University)H-Index: 13
Last. Masafumi MachidaH-Index: 27
view all 4 authors...
Abstract In addition to the induction of scoliosis in chickens by pinealectomy (PINX), we previously demonstrated that removal of the pineal gland also produces scoliosis in bipedal rats, which can be inhibited by melatonin treatment. Using C57BL/6J mice with genetically low circulating melatonin levels, the main objective of the present study was to investigate whether bipedal ambulation in C57BL/6J mice has the same effects on spinal deformity as those seen in pinealectomized bipedal rats. The...
Source
#1Shigeru Nishida (Nihon University)H-Index: 10
#2Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 50
Last. Shigeki Nakagawa (Nihon University)H-Index: 14
view all 4 authors...
Abstract: We previously reported that pharmacological melatonin administration to type 2 diabetic rats reduces hyperinsulinemia and improves the altered fatty-acid metabolism. To determine whether melatonin deficiency exacerbates diabetes-associated conditions, we investigated the effect of pinealectomy (i.e. melatonin-deficiency) on plasma hormone levels and lipid metabolism in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. We compared levels of insulin and leptin, and hepatic ...
Source
We examined the role of melatonin in the pathogenesis of diabetes in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, which served as a model of type 2 diabetes. Six-week-old male OLETF rats were pinealectomized (PINX) and were then subjected to an oral glucose tolerance test (OGTT) and glucose clamping at 33 weeks old. Their liver and quadriceps muscle glycogen levels as well as their plasma levels of various hormones were measured at 35 weeks old. Sham-operated OLETF rats (SO group) displaye...
#1Kimitoshi Kato (Nihon University)H-Index: 19
#2Ichiro Murai (Nihon University)H-Index: 13
Last. Y. Arakawa (Nihon University)H-Index: 11
view all 10 authors...
Background: We previously demonstrated the circadian variation of water-immersion restraint stress (WRS)-induced gastric mucosal lesions in rats. Aim: To investigate the roles of melatonin and prostaglandin in the gastric mucosa in circadian modulation of WRS. Methods: Fasted rats were subjected to 4-h WRS during both the diurnal and nocturnal phases of a light/dark cycle. Mucosal lesions, serum melatonin concentrations, mucosal generation of prostaglandin E2 (PGE2) and mucosal gene expressions ...
Source
#1Shigeru Nishida (Nihon University)H-Index: 10
#2Toshiko Segawa (Nihon University)H-Index: 1
Last. Shigeki Nakagawa (Nihon University)H-Index: 14
view all 4 authors...
The objective of this study was to investigate the effect of long-term melatonin administration on plasma levels of triglycerides, insulin and leptin, and on the fatty-acid metabolism of plasma and hepatic lipids in type 2 diabetic rats. Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, were divided into two groups: one untreated (n=6), and one implanted with time-releasing melatonin pellets (1.1 mg/day for 30 wk) under the abdominal skin (n=6). Age-mat...
Source
#1Masafumi Machida (Nihon University)H-Index: 27
#2Jean DuboussetH-Index: 31
Last. Junnosuke RyuH-Index: 1
view all 7 authors...
Study Design. This study was designed to investigate the pathologic mechanisms of idiopathic scoliosis using experimentally induced scoliosis in chickens. Objective. To understand the process of producing a scoliotic deformity in pinealectomized chickens. Summary of Background Data. Pinealectomy in chickens consistently produces scoliosis with anatomic characteristics similar to those of human idiopathic scoliosis. Pinealectomized chickens are an important animal model for the study of idiopathi...
Source
#1Migusa OtsukaH-Index: 1
#2Kimitoshi KatoH-Index: 19
Last. Yasuyuki Arakawa (Nihon University)H-Index: 31
view all 6 authors...
The roles of melatonin and the pineal gland in the circadian variation of water-immersion restraint stress-induced gastric mucosal lesions in rats were investigated. Fasted rats were subjected to water-immersion restraint stress during both the diurnal and nocturnal phases of a light:dark cycle. Pinealectomized and sham-operated rats were also subjected to water-immersion restraint stress at night. The lesion area after 4 hr of stress during the dark phase was significantly lower than in light-p...
Source
#1Kimitoshi Kato (Nihon University)H-Index: 19
#2Satoshi Asai (Nihon University)H-Index: 27
Last. Yasuyuki Arakawa (Nihon University)H-Index: 31
view all 9 authors...
Systemic administration of melatonin (5 to 20 mg/kg) has been reported to inhibit the induction of acute gastric mucosal lesions by stress or ischemia-reperfusion in rats. We recently demonstrated that intracisternal (i.c.) melatonin at low doses (1 to 100 ng) dose-dependently decreased acid and pepsin outputs in rats. The aim of the present study was to further investigate the peripheral and central roles of melatonin in gastric mucosal defense. Using a radioimmunoassay, we measured melatonin c...
Source
#1Katsutaka Oishi (MITI: Japanese Ministry of International Trade and Industry)H-Index: 37
#2Ichiro Murai (Nihon University)H-Index: 13
Last. Norio Ishida (TITech: Tokyo Institute of Technology)H-Index: 17
view all 7 authors...
Abstract To investigate the functional involvement of the pineal gland in circadian expression of the rat period homolog gene (rPer2) in the suprachiasmatic nucleus (SCN) and peripheral tissues, we performed Northern blot analysis in tissues from pinealectomized rats. The ectomy did not have any significant effects on rPer2 mRNA expression patterns both in a daily light–dark condition and in a constant darkness. These results suggest that the rhythmic secretion of pineal melatonin is not essenti...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.