Frédéric Calon
Laval University
EndocrinologyDopaminergicGenetically modified mousePathologyNeuroscienceChemistryPolyunsaturated fatty acidNeuroprotectionDocosahexaenoic acidBlood–brain barrierMPTPDiseasePutamenParkinson's diseaseAlzheimer's diseaseDopamineBiochemistryMedicineBiologyPharmacology
196Publications
55H-index
9,273Citations
Publications 184
Newest
#1Marine Tournissac (Laval University)H-Index: 5
#2Tra-My Vu (Laval University)H-Index: 1
Last. Frédéric Calon (Laval University)H-Index: 55
view all 9 authors...
BACKGROUND Old age, the most important risk factor for Alzheimer's disease (AD), is associated with thermoregulatory deficits. Brown adipose tissue (BAT) is the main thermogenic driver in mammals and its stimulation, through β3 adrenergic receptor (β3AR) agonists or cold acclimation, counteracts metabolic deficits in rodents and humans. Studies in animal models show that AD neuropathology leads to thermoregulatory deficits, and cold-induced tau hyperphosphorylation is prevented by BAT stimulatio...
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#1Sai Sampath Thammisetty (Laval University)H-Index: 6
#2Laurence RenaudH-Index: 2
Last. Jasna Kriz (Laval University)H-Index: 28
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Vascular dementia is one of the most common forms of dementia in aging population. However, the molecular mechanisms involved in development of disease and the link between the cerebrovascular pathology and the cognitive impairments remain elusive. Currently, one common and/or converging neuropathological pathway leading to dementia is the mislocalization and altered functionality of the TDP-43. We recently demonstrated that brain ischemia triggers an age-dependent deregulation of TDP-43 that wa...
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The scope of evidence on the neuroprotective impact of natural products has been greatly extended in recent years. However, a key question that remains to be answered is whether natural products act directly on targets located in the central nervous system (CNS), or whether they act indirectly through other mechanisms in the periphery. While molecules utilized for brain diseases are typically bestowed with a capacity to cross the blood–brain barrier, it has been recently uncovered that periphera...
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#1Isabelle Guisle (Laval University)
#2Serena Petry (Laval University)
Last. Emmanuel Planel (Laval University)H-Index: 23
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In Alzheimer9s disease (AD), hyper-phosphorylation and aggregation of tau correlates with clinical progression and represents a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna bathing and a lower incidence of dementia and AD, but the molecular mechanisms underlying these benefits remain uncertain. Here, we tested the hypothesis that sauna-like conditions could lower tau phosphorylation by increasing body tem...
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#1Hortense FanetH-Index: 2
#1Fanet H (INAF)H-Index: 1
Last. S. Vancassel (INAF)H-Index: 1
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Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological processes at periphery and central level, such as vascularization, inflammation, glucose homeostasis, regulation of oxidative stress and neurotransmission. BH4 de novo synthesis involves the sequential activation of three enzymes, the major controlling point being GTP cyclohydrolase I (GCH1). Complementary salvage and recycling p...
1 CitationsSource
Background Alzheimer's disease (AD) is a multifactorial disease, implying that multi-target treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an enzymatic cofactor required for the synthesis of monoamines and nitric oxide that also exerts antioxidant and anti-inflammatory effects. Despite its crucial role in the CNS, the potential of BH4 as a treatment in AD has never been scrutinized. Objective Here, we investigated whether BH4 peripheral administration improves c...
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#1Milene Vandal (U of C: University of Calgary)H-Index: 19
#2Colin Gunn (U of C: University of Calgary)
Last. Minh Dang Nguyen (U of C: University of Calgary)H-Index: 27
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#1Milene Vandal (U of C: University of Calgary)H-Index: 19
#2Colin Gunn (U of C: University of Calgary)
Last. Minh Dang Nguyen (U of C: University of Calgary)H-Index: 27
view all 12 authors...
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#1Manon Leclerc (Laval University)
#2Philippe Bourassa (Laval University)H-Index: 6
Last. Frédéric Calon (Laval University)H-Index: 55
view all 9 authors...
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#1Majed Alotaibi (University of Sheffield)
#2Mélissa Lessard-Beaudoin (Université de Sherbrooke)H-Index: 4
Last. Rona K. Graham (Université de Sherbrooke)H-Index: 14
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