Fariborz Samini
Mashhad University of Medical Sciences
Internal medicineEndocrinologySurgeryPathologyRetrospective cohort studyChemistryPediatricsNeuroprotectionSuperoxide dismutaseOxidative stressAntioxidantMalondialdehydeDiseaseLipid peroxidationTraumatic brain injurySafranalIn patientHead traumaAnesthesiaGlutathioneDiabetes mellitusMedicineParenteral nutritionPharmacology
74Publications
16H-index
822Citations
Publications 73
Newest
#1Elham Poonaki (Tehran University of Medical Sciences)
#2Fatemeh Ariakia (MUMS: Mashhad University of Medical Sciences)H-Index: 3
Last. Ali GorjiH-Index: 33
view all 9 authors...
Despite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential novel therapeutic target for GBM. To enhance the efficacy and reduce the toxicity, PTC209, a BMI-1 inhibitor, was loaded into a PLGA–PEG nanoparticle conjugated with CD133 antibody (Nano-PTC209) and its effect on the behavior of human GBM stem-like cells (GSCs) and the human glioblastoma cel...
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#1Tahereh Farkhondeh (Birjand University of Medical Sciences)H-Index: 22
#2Milad Ashrafizadeh (Sabancı University)H-Index: 9
Last. Saeed SamarghandianH-Index: 19
view all 6 authors...
BACKGROUND Glucose/serum deprivation (GSD), has been used for understanding molecular mechanisms of neuronal damage during ischemia. It has been suggested that curcumin may improve neurodegenerative diseases. AIM In this study, the protective effects of curcumin and its underlying mechanisms were investigated in PC12 cells upon GSD-induced stress. METHODS PC12 cells were cultured in DMEM overnight and then incubated in GSD condition for either 6 or 12h. GSD-treated cells were pretreated with var...
2 CitationsSource
#1Fatemeh Ghafouri Taleghani (MUMS: Mashhad University of Medical Sciences)
#2Abdolreza Norouzy (MUMS: Mashhad University of Medical Sciences)H-Index: 11
Last. Asghar Mafinezhad (MUMS: Mashhad University of Medical Sciences)H-Index: 3
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#1Heshmatollah Ghawami (Tehran University of Medical Sciences)
#2Seyed Behnam Jazayeri (Tehran University of Medical Sciences)H-Index: 5
Last. Vafa Rahimi-Movaghar (UT: University of Tehran)H-Index: 66
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Background Individuals with moderate to severe traumatic brain injury (TBI) often have prolonged cognitive impairments, resulting in long-term problems with their real-life activities. Given the urgent need for evidence-based recommendations for neuropsychological management of Iranian TBI patients, the current work aimed to adapt eligible international guidelines for cognitive assessment and rehabilitation of the TBI patients in Iran. Methods The project was led by an executive committee, under...
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#1Maryam KazemiH-Index: 8
#2Mohsen NematyH-Index: 23
Last. Abdolreza NorouzyH-Index: 11
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#1Tahereh Farkhondeh (Birjand University of Medical Sciences)H-Index: 22
#2Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
Last. Saeed SamarghandianH-Index: 19
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Introduction Deposition of amyloid-beta (Aβ) peptide in the brain is the leading source of the onset and progression of Alzheimer's disease (AD). Recent studies have suggested that anti-amyloidogenic agents may be a suitable therapeutic strategy for AD. Aim The current review was proposed to address the beneficial effects of cannabis-based drugs for the treatment of AD, focusing primarily on Aβ modifications. Method Keywords related to AD, Aβ, and cannabis-based on MeSH were identified and were ...
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#1Sajad Sahab-Negah (MUMS: Mashhad University of Medical Sciences)H-Index: 2
#2Fatemeh Ariakia (MUMS: Mashhad University of Medical Sciences)H-Index: 3
Last. Ali GorjiH-Index: 33
view all 8 authors...
: Using a novel curcumin-loaded niosome nanoparticle (CM-NP), the present study was designed to evaluate the effect of curcumin on human glioblastoma stem-like cells (GSCs). CM-NP has a diameter of ~ 60 nm and a zeta potential of ~ - 35 mV with a constant physicochemical stability. The cytotoxic effects of free curcumin (CM) and CM-NP were investigated on GSCs obtained during the removal of a brain tumor. Both CM and CM-NP caused a dose-dependent decrease in cell proliferation and viability of G...
8 CitationsSource
#1Tahereh Farkhondeh (Birjand University of Medical Sciences)H-Index: 22
#2Sediqeh JalaliH-Index: 5
Last. Fariborz Samini (MUMS: Mashhad University of Medical Sciences)H-Index: 16
view all 5 authors...
: The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like behavior induced by chronic restraint stress in rats. The rats were kept in restrainers for 1 hour daily for 21 consecutive days. Then, the animals were daily injected with either vehicle or CH (10, 20, 30 µg/kg) for 21 days. Our findings showed that the serum corticosterone levels significantly increased in rats submitted to the restraint stress versus ...
3 CitationsSource
#1Babak GanjeifarH-Index: 5
#2Ehsan Keykhosravi (MUMS: Mashhad University of Medical Sciences)H-Index: 2
view all 9 authors...
Background: Thoracolumbar spinal fractures include a range of injuries of various severities from simple apophysealfractures to neurological injury and complex fractures associated with vertebral dislocation. The treatment ofthoracolumbar fractures is challenging, especially due to the difficulty of evaluating the posterior ligamentous complex(PLC). The purpose of this study was to evaluate the diagnostic value of computed tomography (CT) scan in predictingPLC injuries in the patients with thora...
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#1Sajad Sahab Negah (MUMS: Mashhad University of Medical Sciences)H-Index: 8
#2Pardis Oliazadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 1
Last. Ali GorjiH-Index: 33
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Abstract Traumatic brain injury (TBI) can result in permanent brain function impairment due to the poor regenerative ability of neural tissue. Tissue engineering has appeared as a promising approach to promote nerve regeneration and to ameliorate brain damage. The present study was designed to investigate the effect of transplantation of the human meningioma stem-like cells (hMgSCs) seeded in a promising three-dimensional scaffold (RADA4GGSIKVAV; R-GSIK) on the functional recovery of the brain a...
15 CitationsSource