Francesco Pappalardo
University of Catania
CancerInternal medicineOncologyArtificial intelligenceImmunologyVaccinationData scienceIn silicoCancer vaccineDiseaseMultiple sclerosisVaccination scheduleMammary carcinomaComputer scienceBioinformaticsComputational modelComputational biologyMedicineBiologyGenetic algorithmImmune system
121Publications
23H-index
1,427Citations
Publications 118
Newest
#1Giulia Russo (University of Catania)H-Index: 27
#2Valentina Di Salvatore (University of Catania)H-Index: 3
Last. Francesco Pappalardo (University of Catania)H-Index: 23
view all 6 authors...
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The value of in silico methods in drug development and evaluation has been demonstrated repeatedly and convincingly. While their benefits are now unanimously recognized, international standards for their evaluation, accepted by all stakeholders involved, are still to be established. In this white paper, we propose a risk-informed evaluation framework for mechanistic model credibility evaluation. To properly frame the proposed verification and validation activities, concepts such as context of us...
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#1Giuseppe Sgroi (University of Catania)H-Index: 3
#2Giulia Russo (University of Catania)H-Index: 13
Last. Francesco Pappalardo (University of Catania)H-Index: 23
view all 3 authors...
SUMMARY Although several bioinformatics tools have been developed to examine signaling pathways, little attention has been given to ever long-distance crosstalk mechanisms. Here, we developed PETAL, a Python tool that automatically explores and detects the most relevant nodes within a KEGG pathway, scanning and performing an in-depth search. PETAL can contribute to discovering novel therapeutic targets or biomarkers that are potentially hidden and not considered in the network under study. AVAIL...
2 CitationsSource
The term "In Silico Trial" indicates the use of computer modelling and simulation to evaluate the safety and efficacy of a medical product, whether a drug, a medical device, a diagnostic product or an advanced therapy medicinal product. Predictive models are positioned as new methodologies for the development and the regulatory evaluation of medical products. New methodologies are qualified by regulators such as FDA and EMA through formal processes, where a first step is the definition of the Co...
#1Massimiliano Zanin (UPM: Technical University of Madrid)H-Index: 24
#2Nadim A.A. Aitya (Ulster University)H-Index: 1
Last. Blandine Comte (University of Auvergne)H-Index: 29
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Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues...
1 CitationsSource
#1Marco Viceconti (UNIBO: University of Bologna)H-Index: 67
#2Francesco Pappalardo (University of Catania)H-Index: 23
Last. Flora Musuamba TshinanuH-Index: 2
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Abstract Historically, the evidences of safety and efficacy that companies provide to regulatory agencies as support to the request for marketing authorization of a new medical product have been produced experimentally, either in vitro or in vivo. More recently, regulatory agencies started receiving and accepting evidences obtained in silico, i.e. through modelling and simulation. However, before any method (experimental or computational) can be acceptable for regulatory submission, the method i...
16 CitationsSource
#1Valentina Di Salvatore (University of Catania)H-Index: 3
#2Daniela Formica (University of Catania)
Last. Francesco Pappalardo (University of Catania)H-Index: 23
view all 5 authors...
One of the main problems in the fight against cancer is represented by the immunosuppression it causes. Several research lines have been undertaken to address this issue; one of the most promising is represented by oncolytic viruses. Oncolytic viruses are designed from live attenuated recombinant viruses and are designed to preferentially infect cancer cells, within which they replicate causing their lysis and enhance, through various mechanisms, innate and adaptive immunity. In collaboration wi...
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#1Giuseppe Sgroi (University of Catania)H-Index: 3
#2Marzio Pennisi (University of Eastern Piedmont)H-Index: 20
Last. Giuseppe Alessandro Parasiliti Palumbo (University of Catania)H-Index: 2
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An ever-increasing number of tools and databases offers pieces of evidence and knowledge about gene function annotations, protein interactions, and experimentally validated biological pathways. These resources represent an excellent and essential instrument to facilitate pathway analysis. Among them, particular attention should be given to the one capable of finding alternative pathways or cross-talks events and potential drug target candidates. Here, we evaluated PETAL predictive capability, a ...
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#1Giulia Russo (University of Catania)H-Index: 13
#1Giulia Russo (University of Catania)H-Index: 27
Last. Francesco Pappalardo (University of Catania)H-Index: 23
view all 7 authors...
SARS-CoV-2 is a severe respiratory infection that infects humans. Its outburst entitled it as a pandemic emergence. To get a grip on this outbreak, specific preventive and therapeutic interventions are urgently needed. It must be said that, until now, there are no existing vaccines for coronaviruses. To promptly and rapidly respond to pandemic events, the application of in silico trials can be used for designing and testing medicines against SARS-CoV-2 and speed-up the vaccine discovery pipeline...
2 CitationsSource
#1Simone Pernice (UNITO: University of Turin)H-Index: 2
#2Laura Follia (UNITO: University of Turin)H-Index: 3
Last. Simona Rolla (UNITO: University of Turin)H-Index: 16
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Background Multiple Sclerosis (MS) represents nowadays in Europe the leading cause of non-traumatic disabilities in young adults, with more than 700,000 EU cases. Although huge strides have been made over the years, MS etiology remains partially unknown. Furthermore, the presence of various endogenous and exogenous factors can greatly influence the immune response of different individuals, making it difficult to study and understand the disease. This becomes more evident in a personalized-fashio...
1 CitationsSource