Mariane Bertagnolli
Université de Montréal
Angiotensin receptorInternal medicineEndocrinologyProinflammatory cytokineCardiologyMuscle hypertrophyHemodynamicsChemistryRenin–angiotensin systemProgenitor cellYoung adultOxidative stressHeart failureBronchopulmonary dysplasiaDiseasePregnancyAngiogenesisHyperoxiaMedicineBlood pressureBiology
48Publications
15H-index
670Citations
Publications 53
Newest
#1Hamdi A. Jama (Monash University)H-Index: 6
#2Rikeish R. Muralitharan (Ministry of Health (Malaysia))H-Index: 4
Last. Francine Z. Marques (Monash University)H-Index: 30
view all 8 authors...
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular disease. As a multifactorial and systemic disease that involves multiple organs and systems, hypertension remains a challenging disease to study. Models of hypertension are invaluable to support the discovery of the specific genetic, cellular and molecular mechanisms underlying essential hypertension, as well as to test new possible treatments to lower BP. Rodent models have proven to be an invaluable tool ...
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#1Adam J. Lewandowski (University of Oxford)H-Index: 32
#2Betty Raman (University of Oxford)H-Index: 9
Last. Paul Leeson (University of Oxford)H-Index: 48
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BACKGROUND Preterm birth affects about 10% of live births worldwide and is associated with cardiac alterations. Animal models of preterm birth suggest that left ventricular functional impairment may be due to an up-regulation of myocardial fibrosis. OBJECTIVES The aim of this study was to determine whether diffuse left ventricular fibrosis is evident in young adults born preterm. METHODS One hundred one normotensive young adults born preterm (n = 47, mean gestational age 32.8 ± 3.2 weeks) and te...
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#1Nayara Azinheira Nobrega Cruz (UNIFESP: Federal University of São Paulo)
#2Danielle Stoll (UNIFESP: Federal University of São Paulo)H-Index: 1
Last. Mariane Bertagnolli (McGill University)H-Index: 15
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In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manife...
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#1Tan Cmj. (University of Oxford)H-Index: 2
#2Adam J. Lewandowski (University of Oxford)H-Index: 32
Last. Paul Leeson (University of Oxford)H-Index: 48
view all 11 authors...
Background A subpopulation of endothelial progenitor cells called endothelial colony‐forming cells (ECFCs) may offer a platform for cellular assessment in clinical studies because of their remarkab...
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Last. Mariane Bertagnolli (McGill University)H-Index: 15
view all 7 authors...
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#1Nozha RaguemaH-Index: 1
#2Sarah MoustadrafH-Index: 1
Last. Mariane BertagnolliH-Index: 15
view all 3 authors...
Preeclampsia is the most severe type of hypertensive disorder of pregnancy, affecting one in 10 pregnancies worldwide and increasing significantly maternal and neonatal morbidity and mortality. Women developing preeclampsia display an array of symptoms encompassing uncontrolled hypertension and proteinuria, with neurological symptoms including seizures at the end of pregnancy. The main causes of preeclampsia are still unknown. However, abnormal placentation and placenta vascularization seem to b...
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#1Muhammad Oneeb Rehman Mian (UdeM: Université de Montréal)H-Index: 3
#2Ying He (UdeM: Université de Montréal)H-Index: 24
Last. Anne Monique Nuyt (UdeM: Université de Montréal)H-Index: 32
view all 9 authors...
Preterm birth is associated with proinflammatory conditions and alterations in adult cardiac shape and function. Neonatal exposure to high oxygen, a rat model of prematurity-related conditions, lea...
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#1Nissim Benizri (McGill University)
#2Nozha RaguemaH-Index: 2
Last. Mariane BertagnolliH-Index: 15
view all 6 authors...
Background: Hypertensive disorders reach one in ten pregnancies worldwide, significantly increasing rates of maternal and neonatal morbidity and mortality. Children born to hypertensive pregnancies...
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Background: Thrombospondin-1 (Thbs1) is an anti-angiogenic focal adhesion glycoprotein. It binds to receptors CD36, LRP1 and CD47 activating anti-proliferative and anti-migratory mechanisms. Pre-ec...
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#1Camille Girard-Bock (UdeM: Université de Montréal)H-Index: 4
#2Carla C. de Araújo (UdeM: Université de Montréal)H-Index: 1
Last. Anne Monique Nuyt (UdeM: Université de Montréal)H-Index: 32
view all 11 authors...
: Very preterm birth is associated with increased cardiovascular diseases and changes in myocardial structure. The current study aimed to investigate the impact of endothelial colony-forming cell (ECFC) treatment on heart morphological changes in the experimental model of neonatal high oxygen (O2 )-induced cardiomyopathy, mimicking prematurity-related conditions. Sprague-Dawley rat pups exposed to 95% O2 or room air (RA) from day 4 (P4) to day 14 (P14) were randomized to receive (jugular vein) e...
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