Elena De Falco
Sapienza University of Rome
Regenerative medicineCell therapyEndothelial stem cellPhenotypeEndocrinologyPathologyAdipose tissueMesenchymal stem cellProgenitor cellIn vitroImmunologyOxidative stressPlatelet lysateHeart failureStem cellCancer researchMedicineCell cultureBiologyCell biology
Publications 72
#1Giacomo Frati (Sapienza University of Rome)H-Index: 47
#2Maurizio ForteH-Index: 22
Last. Sebastiano Sciarretta (Sapienza University of Rome)H-Index: 38
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Background The role of microRNAs dysregulation in tobacco cigarette smoking–induced vascular damage still needs to be clarified. We assessed the acute effects of tobacco cigarette smoking on endoth...
#1Gianluca Caruso (Sapienza University of Rome)H-Index: 1
#2Luca Pacini (Sapienza University of Rome)H-Index: 9
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
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1 CitationsSource
#1Maurizio ForteH-Index: 22
#2Franca BianchiH-Index: 9
Last. Sebastiano Sciarretta (Sapienza University of Rome)H-Index: 38
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ABSTRACTThe identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autopha...
21 CitationsSource
#1Colin E. Murdoch (Dund.: University of Dundee)H-Index: 19
#2Elena De Falco (Sapienza University of Rome)H-Index: 19
#1Carmela Rita Balistreri (University of Palermo)H-Index: 31
#2Elena De Falco (Sapienza University of Rome)H-Index: 19
Last. Alexander VaisermanH-Index: 27
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Stem cell therapy (SCT), born as therapeutic revolution to replace pharmacological treatments, remains a hope and not yet an effective solution. Accordingly, stem cells cannot be conceivable as a “canonical” drug, because of their unique biological properties. A new reorientation in this field is emerging, based on a better understanding of stem cell biology and use of cutting-edge technologies and innovative disciplines. This will permit to solve the gaps, failures, and long-term needs, such as...
4 CitationsSource
#1Giacomo Frati (Sapienza University of Rome)H-Index: 47
#2Roberto Carnevale (Sapienza University of Rome)H-Index: 36
Last. Giuseppe Biondi-Zoccai (Sapienza University of Rome)H-Index: 79
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Modified risk products (MRP) are promoted as a safer alternative to traditional combustion cigarettes (TCC) in chronic smokers. Evidence for their lower hazardous profile is building, despite several controversies. Yet, it is unclear whether individual responses to MRP differ among consumers. We hypothesized that different clusters of subjects exist in terms of acute effects of MRP. Pooling data from a total of 60 individuals, cluster analysis identified at least three clusters (labelled 1 to 3)...
11 CitationsSource
#1Eleonora Scaccia (Sapienza University of Rome)H-Index: 2
#2Antonella Bordin (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
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Abstract Although controlling a wide range of physiological cell functions, redox states unbalance during inflammation toward oxidative stress. Specific regions of our genome are extremely sensitive to both oxygen and reactive oxygen species, therefore modulating gene transcription in response to this specific epigenetic effect. Additional epigenetic mechanisms may include the alteration of the methylation states of DNA, protein and lipid nitration or modulation of specific microRNAs. A crucial ...
#1Alexander VaisermanH-Index: 27
#2Elena De Falco (Sapienza University of Rome)H-Index: 19
Last. Carmela Rita Balistreri (University of Palermo)H-Index: 31
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Abstract Improving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved ...
5 CitationsSource
#1Francesca Pagano (Sapienza University of Rome)H-Index: 13
#2Vittorio Picchio (Sapienza University of Rome)H-Index: 5
Last. Antonino G.M. Marullo (Sapienza University of Rome)H-Index: 18
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Purpose of Review Cardiac regenerative medicine is a field bridging together biotechnology and surgical science. In this review, we present the explored surgical roads to cell delivery and the known effects of each delivery method on cell therapy efficiency. We also list the more recent clinical trials, exploring the safety and efficacy of delivery routes used for cardiac cell therapy approaches.
5 CitationsSource
#1Heba Abdelrazik (Cairo University)H-Index: 2
#2Emanuele Giordano (UNIBO: University of Bologna)H-Index: 22
Last. Alessandra Pelagalli (University of Naples Federico II)H-Index: 14
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Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipula...
9 CitationsSource
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