Elena De Falco
Sapienza University of Rome
Regenerative medicineCell therapyEndothelial stem cellPhenotypeEndocrinologyPathologyStromal cellMesenchymal stem cellProgenitor cellImmunologyOxidative stressPlatelet lysateDiseaseStem cellCancer researchBioinformaticsCell growthMedicineBiologyCell biology
Publications 75
#1Elena De Falco (Sapienza University of Rome)H-Index: 20
#2Luca Pacini (Sapienza University of Rome)H-Index: 9
Last. Antonella Calogero (Sapienza University of Rome)H-Index: 20
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Colorectal cancer (CRC) is rapidly increasing representing the second most frequent cause of cancer-related deaths. From a clinical-molecular standpoint the therapeutically management of CRC focuses on main alterations found in the RAS family protein, where single mutations of KRAS are considered both the hallmark and the target of this tumor. Double and concomitant alterations of KRAS are still far to be interpreted as molecular characteristics which could potentially address different and more...
Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for the first time that NPM is secreted by human vein endothelial cells (HUVEC) in the early response to serum deprivation and that NPM acts as a pro-inflammatory and angiogenic molecule both in vitro and in vivo. Accordingly, 24 h of serum starvation cond...
#1Lorenzo LoffredoH-Index: 37
#2Roberto CarnevaleH-Index: 40
Last. Giacomo FratiH-Index: 60
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Tobacco habit still represents the leading preventable cause of morbidity and mortality worldwide. Heat-not-burn cigarettes (HNBCs) are considered as an alternative to traditional combustion cigarettes (TCCs) due to the lack of combustion and the absence of combustion-related specific toxicants. The aim of this observational study was to assess the effect of HNBC on endothelial function, oxidative stress and platelet activation in chronic adult TCC smokers and HNBC users. The results showed that...
1 CitationsSource
#1Giacomo Frati (Sapienza University of Rome)H-Index: 60
#2Maurizio ForteH-Index: 24
Last. Sebastiano Sciarretta (Sapienza University of Rome)H-Index: 49
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Background The role of microRNAs dysregulation in tobacco cigarette smoking–induced vascular damage still needs to be clarified. We assessed the acute effects of tobacco cigarette smoking on endoth...
1 CitationsSource
#1Gianluca Caruso (Sapienza University of Rome)H-Index: 3
#2Luca Pacini (Sapienza University of Rome)H-Index: 9
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
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1 CitationsSource
#1Maurizio ForteH-Index: 24
#2Franca BianchiH-Index: 10
Last. Sebastiano Sciarretta (Sapienza University of Rome)H-Index: 49
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ABSTRACTThe identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autopha...
19 CitationsSource
#1Colin E. Murdoch (Dund.: University of Dundee)H-Index: 20
#2Elena De Falco (Sapienza University of Rome)H-Index: 20
#1Carmela Rita Balistreri (University of Palermo)H-Index: 32
#2Elena De Falco (Sapienza University of Rome)H-Index: 20
Last. Alexander VaisermanH-Index: 27
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Stem cell therapy (SCT), born as therapeutic revolution to replace pharmacological treatments, remains a hope and not yet an effective solution. Accordingly, stem cells cannot be conceivable as a “canonical” drug, because of their unique biological properties. A new reorientation in this field is emerging, based on a better understanding of stem cell biology and use of cutting-edge technologies and innovative disciplines. This will permit to solve the gaps, failures, and long-term needs, such as...
4 CitationsSource
#1Giacomo Frati (Sapienza University of Rome)H-Index: 60
#2Roberto Carnevale (Sapienza University of Rome)H-Index: 40
Last. Giuseppe Biondi-Zoccai (Sapienza University of Rome)H-Index: 102
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Modified risk products (MRP) are promoted as a safer alternative to traditional combustion cigarettes (TCC) in chronic smokers. Evidence for their lower hazardous profile is building, despite several controversies. Yet, it is unclear whether individual responses to MRP differ among consumers. We hypothesized that different clusters of subjects exist in terms of acute effects of MRP. Pooling data from a total of 60 individuals, cluster analysis identified at least three clusters (labelled 1 to 3)...
12 CitationsSource
#1Eleonora Scaccia (Sapienza University of Rome)H-Index: 3
#2Antonella Bordin (Sapienza University of Rome)H-Index: 9
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
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Abstract Although controlling a wide range of physiological cell functions, redox states unbalance during inflammation toward oxidative stress. Specific regions of our genome are extremely sensitive to both oxygen and reactive oxygen species, therefore modulating gene transcription in response to this specific epigenetic effect. Additional epigenetic mechanisms may include the alteration of the methylation states of DNA, protein and lipid nitration or modulation of specific microRNAs. A crucial ...