Tao Xu
Shanghai Jiao Tong University
CancerDownregulation and upregulationWnt signaling pathwaymicroRNANociceptionReceptorHepatic stellate cellChemistryApoptosisInflammationMorphineAnalgesicMetabotropic glutamate receptor 5Cancer researchCell growthSignal transductionMedicineBiologyCell biologyPharmacology
Publications 73
#1Cong-Cong Sun (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 1
#2Shuai Zhao (Hefei University)H-Index: 1
Last. Hua Wang (Anhui Medical University)H-Index: 52
view all 15 authors...
Abstract null null Di (2-ethyl-hexyl) phthalate (DEHP) is a widely used plasticizer. Maternal DEHP exposure inhibits cell proliferation and reduces placentas size, which associates with fetal growth restriction and adulthood diseases. However, the mechanism of placental cell proliferation inhibition by DEHP remains elusive. This study investigated the effect of DEHP on placental cell proliferation from cell cycle arrest. Utilizing in vitro and in vivo experiments, we investigated cell cycle arre...
cGAS-STING signaling pathway is an autoimmune inflammatory pathway discovered in 2013, which can trigger the expression of a series of inflammatory factors represented by type 1 interferon. As an important immune organ, cGAS-STING signaling pathway plays a significant role in liver physiology. Recent studies have found that cGAS-STING signaling pathway is closely related to the progress of liver diseases. For example, activation of cGAS-STING signaling pathway can significantly inhibit HBV repli...
#1Xiang MengH-Index: 1
#2Qiu-Yue Lou (Anhui Medical University)
Last. Lei Zhang (Anhui Medical University)H-Index: 34
view all 8 authors...
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5-fluorouracil, and paclitaxel have now become the first-line options for OSCC patients. Nevertheless, most OSCC patients eventually acquire drug resistance, leading to poor prognosis. With the discovery and identification of non-coding RNAs (ncRNAs), the functions of ...
#1Xiaotao Xu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Kaixuan Wu (SJTU: Shanghai Jiao Tong University)
Last. Haibo ShiH-Index: 16
view all 13 authors...
Stress contributes to major depressive disorder (MDD) and chronic pain, which affect a significant portion of the global population, but researchers have not clearly determined how these conditions are initiated or amplified by stress. The chronic social defeat stress (CSDS) model is a mouse model of psychosocial stress that exhibits depressive-like behavior and chronic pain. We hypothesized that metabotropic glutamate receptor 5 (mGluR5) expressed in the nucleus accumbens (NAc) normalizes the d...
#1Zhe ShiH-Index: 3
#2Meng Qin (Huada: Beijing University of Chemical Technology)H-Index: 2
Last. Xinmin Liu (Hunan University)H-Index: 25
view all 17 authors...
During a long-duration manned spaceflight mission, such as flying to Mars and beyond, all crew members will spend a long period in an independent spacecraft with closed-loop bioregenerative life-support systems. Saving resources and reducing medical risks, particularly in mental heath, are key technology gaps hampering human expedition into deep space. In the 1960s, several scientists proposed that an induced state of suppressed metabolism in humans, which mimics 'hibernation', could be an ideal...
#1Jing Dong (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yu ZhangH-Index: 1
Last. Tao XuH-Index: 16
view all 10 authors...
BACKGROUND Ultrasound-guided posterior lumbar plexus block is widely used for hip fracture surgery but it requires a change of position, which may be painful. OBJECTIVES Our primary objective was to describe a new technique, the anterior iliopsoas muscle space block, which can be performed in the supine position, and to test the hypothesis that its analgesia for hip surgery was similar to that of the traditional posterior lumbar plexus block. DESIGN Randomised, double-blind study. SETTING Shangh...
#1Haiyan Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Min Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Tao Xu (SJTU: Shanghai Jiao Tong University)H-Index: 16
view all 12 authors...
Abstract Background and Purpose The aim of this work was to investigate the role and signal transduction of toll-like receptor 4 (TLR4), TGF-β-activated kinase 1 (TAK1) and nod-like receptor protein 3 (NLRP3) in microglial in the development of morphine-induced antinociceptive tolerance. Methods TLR4 and NLRP3 knockout mice and 5Z-7-oxozeaeno (a selective inhibitor against TAK1 activity) were used to observe their effect on the development of morphine tolerance. Intrathecal injections of morphin...
1 CitationsSource
#1Min Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Shaofeng Pu (SJTU: Shanghai Jiao Tong University)
Last. Tao Xu (SJTU: Shanghai Jiao Tong University)H-Index: 16
view all 5 authors...
Abstract SHANK3 is one of the scaffolding proteins in the postsynaptic density (PSD). Pain perception and underlying mechanisms were investigated in Shank3 exon 21 deficient (Shank3△C) mice. Sixty-six mice were attributed according to their genotype to three groups: (1) wild-type (WT), (2) heterozygous Shank3△C/+, and (3) homozygous Shank3△C/△C. Complete Freund’s adjuvant (CFA) was used to induce inflammatory pain, and thermal hyperalgesia was determined. CFA treatment reduced the thermal thresh...
#1Liang-yun Li (Anhui Medical University)H-Index: 3
#2Junfa Yang (Anhui Medical University)H-Index: 5
Last. Tao Xu (Anhui Medical University)H-Index: 16
view all 13 authors...
Zinc finger E-box-binding homeobox 1 (ZEB1), a functional protein of zinc finger family, was aberrant expressed in many kinds of liver disease including hepatic fibrosis and Hepatitis C virus. Bioinformatics results showed that ZEB1 was abnormally expressed in HCC tissues. However, to date, the potential regulatory role and molecular mechanisms of ZEB1 are still unclear in the occurrence and development of HCC. This study demonstrated that the expression level of ZEB1 was significantly elevated ...
#1Shuang HuH-Index: 3
#2Pan-pan LianH-Index: 1
Last. Huan ZhouH-Index: 4
view all 17 authors...
It is known that liver diseases have several characteristics of massive lipid accumulation and lipid metabolic disorder, and are divided into inflammation, liver fibrosis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC) in patients. Interleukin (IL)-35, a new-discovered cytokine, can protect the liver from the environmental attack by increasing the ratio of Tregs (T regulatory cells) which can increase the anti-inflammatory cytokines and inhibit the proliferation of immune cellular. Also,...