Sönke Detlefsen
Odense University Hospital
Internal medicineRadiologyPathologyOncologyImmunohistochemistryBiopsyPancreatitisSteatosisChemotherapyLiver diseaseAlcoholic liver diseaseCongenital hyperinsulinismAutoimmune pancreatitisPancreasDiseasePancreatic cancerFibrosisIn patientMedicineBiologyGastroenterology
162Publications
21H-index
2,087Citations
Publications 159
Newest
#1Ming Tan (OUH: Odense University Hospital)H-Index: 2
#2Klaus Brusgaard (University of Southern Denmark)H-Index: 27
Last. Maiken Thyregod Joergensen (OUH: Odense University Hospital)H-Index: 10
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Background null Familial Pancreatic Cancer (FPC) is responsible for up to 10% of all cases of pancreatic ductal adenocarcinoma (PDAC). Individuals predisposed for FPC have an estimated lifetime risk of 16-39% of developing PDAC. While heritability of PDAC has been estimated to be 36% in a Nordic twin study, no heritability estimate specific on FPC has been reported. null Methods null A national cohort of Danish families with predisposition for FPC is currently included in a screening program for...
1 CitationsSource
#1Carolin Lackner (University of Graz)H-Index: 33
#2Rudolf E. Stauber (Medical University of Graz)H-Index: 56
Last. Peter Schirmacher (University Hospital Heidelberg)H-Index: 97
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Abstract null null Background & Aims null The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. null null null Methods null SALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The histological diagnosis of s...
1 CitationsSource
#1Ditlev Nytoft Rasmussen (OUH: Odense University Hospital)H-Index: 4
#2Maja Thiele (OUH: Odense University Hospital)H-Index: 20
Last. Ema AnastasiadouH-Index: 12
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ABSTRACT null null Background & aims null Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking. null null null Methods null Prospective cohort study of patients with early, compensated alcohol-related liver disease. At baseline, we ...
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#1Ming TanH-Index: 2
#2Klaus BrusgaardH-Index: 27
view all 7 authors...
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#1Ming TanH-Index: 2
#2Klaus BrusgaardH-Index: 27
view all 7 authors...
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#1Line Schmidt Tarpgaard (OUH: Odense University Hospital)H-Index: 8
#2Camilla Qvortrup (UCPH: University of Copenhagen)H-Index: 20
Last. Per Pfeiffer (University of Southern Denmark)H-Index: 48
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We have previously published an article describing the protocol for a clinical, non-randomized phase II study (Eudract no. 2013-001648-79) [1], which aimed to provide proof of concept for introduci...
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#1A P Bjarnesen (OUH: Odense University Hospital)
#2P Dahlin (OUH: Odense University Hospital)
Last. Michael Bau Mortensen (OUH: Odense University Hospital)H-Index: 20
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BACKGROUND In congenital hyperinsulinism (CHI), preoperative prediction of the histological subtype (focal, diffuse, or atypical) relies on genetics and 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine (18F-DOPA) PET-CT. The scan also guides the localization of a potential focal lesion along with perioperative frozen sections. Intraoperative decision-making is still challenging. This study aimed to describe the characteristics and potential clinical impact of intraoperative ultrasound imaging (IOUS) d...
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#1Maximilian J. BrolH-Index: 4
#2Stella GeorgiouH-Index: 2
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Background: The prevalence of metabolic liver diseases is increasing and approved pharmacological treatments are still missing. Many animal models of nonalcoholic fatty liver disease (NAFLD) show a full spectrum of fibrosis, inflammation and steatosis, which does not reflect the human situation since only up to one third of the patients develop fibrosis and nonalcoholic steatohepatitis (NASH). Methods: Seven week old C57Bl/J mice were treated with ethanol, Western diet (WD) or both. The animals’...
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#1Martin Graversen (University of Southern Denmark)H-Index: 9
#2Sönke Detlefsen (OUH: Odense University Hospital)H-Index: 21
Last. Michael Bau Mortensen (OUH: Odense University Hospital)H-Index: 20
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#1Lukas Gammelgaard Rasmussen (University of Southern Denmark)
#2Caroline S. Verbeke (University of Oslo)H-Index: 39
Last. Sönke Detlefsen (University of Southern Denmark)H-Index: 21
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Abstract Background/objectives Various classifications of pancreatic ductal adenocarcinoma (PDAC) based on RNA-profiling resulted in two main subtypes. Kalimuthu and coworkers proposed a morphology-based classification that concurred with these subtypes. Immune therapy approaches were so far disappointing in PDAC. Morphological PDAC subtypes may differ regarding key immune-oncology pathways. We aimed to examine the reproducibility and prognostic value of Kalimuthu's subtypes, and to evaluate dif...
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