Roberta L. DeBiasi
George Washington University
Internal medicineSurgeryPathologyMagnetic resonance imagingVirologyRetrospective cohort studyFetusIntensive care medicinePediatricsApoptosisCohort studyImmunologyVirusZika virusDiseasePregnancyMEDLINEMeningitisPopulation2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineCohortEncephalitisBiology
Publications 88
#1Jennifer Burney (UCSD: University of California, San Diego)H-Index: 19
#2Laurel L. DeHaan (UCSD: University of California, San Diego)H-Index: 4
Last. Andras Bratincsak (U.H.: University of Hawaii at Manoa)H-Index: 9
view all 18 authors...
In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This finding raised the question of whether other locations around the world experience similar temporal clusters of KD that might offer clues to disease etiology. Here we combine data from San Diego and nine additional...
#1Jane C. Burns (UCSD: University of California, San Diego)H-Index: 83
#2Samantha C. Roberts (UCSD: University of California, San Diego)H-Index: 5
Last. Dongngan T. Truong (Primary Children's Hospital)H-Index: 8
view all 56 authors...
Background null Although intravenous immunoglobulin (IVIG) is effective therapy for Kawasaki disease, 10-20% of patients have recrudescent fever as a sign of persistent inflammation and require additional treatment. We aimed to compare infliximab with a second infusion of IVIG for treatment of resistant Kawasaki disease. null Methods null In this multicentre comparative effectiveness trial, patients (aged 4 weeks to 17 years) with IVIG resistant Kawasaki disease and fever at least 36 h after com...
#1Xiaoyan Song (GW: George Washington University)H-Index: 26
#2Meghan Delaney (GW: George Washington University)H-Index: 27
Last. Roberta L. DeBiasi (GW: George Washington University)H-Index: 21
view all 6 authors...
Objectives null To describe the incidence of seasonal respiratory viral infections (s-RVIs) before and during the coronavirus disease 2019 (COVID-19) pandemic and to compare virus-specific patient outcomes in pediatric patients. null Design null A retrospective cross-sectional study including patient admissions to the Children's National Hospital between October 1, 2015, and December 31, 2020. null Results null Among 12,451 patient admissions between March 15 and December 31, 2020 (cohort 1), 8,...
Background: Despite similar rates of infection, adults and children have markedly different morbidity and mortality related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Compared to adults, children have infrequent severe manifestations of acute infection but are uniquely at risk for the rare and often severe Multisystem Inflammatory Syndrome in Children (MIS-C) following infection. The cause of these differences in presentation may relate to differences in the host response t...
#1Ashraf S Harahsheh (GW: George Washington University)H-Index: 11
#2Anita Krishnan (GW: George Washington University)H-Index: 2
Last. Charles I. Berul (GW: George Washington University)H-Index: 30
view all 23 authors...
Background null A novel paediatric disease, multi-system inflammatory syndrome in children, has emerged during the 2019 coronavirus disease pandemic. null Objectives null To describe the short-term evolution of cardiac complications and associated risk factors in patients with multi-system inflammatory syndrome in children. null Methods null Retrospective single-centre study of confirmed multi-system inflammatory syndrome in children treated from 29 March, 2020 to 1 September, 2020. Cardiac comp...
The estimated severe acute respiratory syndrome coronavirus 2 seroprevalence in children was found to be 9.46% for the Washington Metropolitan area. Hispanic/Latinx individuals were found to have higher odds of seropositivity. While chronic medical conditions were not associated with having antibodies, previous fever and body aches were predictive symptoms.
#1Roberta L. DeBiasiH-Index: 21
#2Ashraf S HarahshehH-Index: 11
Last. Meghan DelaneyH-Index: 27
view all 41 authors...
Objective null To assess demographic, clinical, and biomarker features distinguishing patients with Multisystem inflammatory syndrome in children (MIS-C); compare MIS-C sub-phenotypes; identify cytokine biosignatures; and characterize viral genome sequences. null null null Study design null We performed a prospective observational cohort study of 124 children hospitalized and treated under the institutional MIS-C Task Force protocol from March-September 2020 at Children’s National, a quaternary ...
#1Roberta L. DeBiasi (GW: George Washington University)H-Index: 21
Since the sudden emergence of multisystem inflammatory disease in children (MIS-C) in April 2020 as a novel and severe presentation of coronavirus disease 2019 (Covid-19), nearly 4000 cases of MIS-...
#1Sarah B. Mulkey (GW: George Washington University)H-Index: 17
#2Emily Ansusinha (GW: George Washington University)
Last. Roberta L. DeBiasi (GW: George Washington University)H-Index: 21
view all 20 authors...
The objective of the study was to describe the complexity of diagnosis and evaluation of Zika-exposed pregnant women/fetuses and infants in a U.S. Congenital Zika Program. Pregnant women/fetuses and/or infants referred for clinical evaluation to the Congenital Zika Program at Children's National (Washington, DC) from January 2016 to June 2018 were included. We recorded the timing of maternal Zika-virus (ZIKV) exposure and ZIKV laboratory testing results. Based on laboratory testing, cases were e...
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