Lívia Bracht
Universidade Estadual de Maringá
Internal medicineEndocrinologyCarbohydrate metabolismChemistryGlycolysisGluconeogenesisOxidative stressSimvastatinInflammationArthritisAntioxidantEzetimibeMitochondrionFood scienceReactive oxygen speciesBiochemistryOxidative phosphorylationMedicineBiologyPharmacology
42Publications
13H-index
383Citations
Publications 44
Newest
#1Kaiany S. Souza (UEM: Universidade Estadual de Maringá)
#2Lucas Stafuza Moreira (UEM: Universidade Estadual de Maringá)H-Index: 2
Last. Jacqueline Nelisis ZanoniH-Index: 18
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Abstract null null Aims null Quercetin has been investigated as an agent to treat rheumatoid arthritis. At high doses it improves inflammation and the antioxidant status of arthritic rats, but it also exerts mitochondriotoxic and pro-oxidant activities. Beneficial effects of quercetin have not been found at low doses because of its chemical instability and low bioavailability. In the hope of overcoming these problems this study investigated the effects of long-term administration of quercetin-lo...
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#1Anielle de Oliveira (UTFPR: Federal University of Technology - Paraná)H-Index: 5
#2Thaysa Fernandes Moya Moreira (UTFPR: Federal University of Technology - Paraná)H-Index: 5
Last. Lillian Barros (IPN: Instituto Politécnico Nacional)H-Index: 78
view all 14 authors...
The objective of this work was to determine the potential bioactive properties of extracts from bio-residues of pinhao (Araucaria angustifolia (Bertol.) Kuntze) seeds, namely the α-amylase and cholinesterase inhibition, cytotoxicity, and anti-inflammatory properties. The pinhao extracts evaluated were obtained from cooking water (CW) and as an ethanolic extract from residual pinhao seed shells (PS). Catechin was the major compound found in both extracts. The PS extract presented higher antioxida...
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#2Lívia BrachtH-Index: 13
Last. Adelar BrachtH-Index: 33
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The purpose of this study was to perform a parallel and comparative investigation of the effects of a Myrciaria jaboticaba (common name jabuticaba) peel extract and of its constituent cyanidin-3-O-glucoside on the overall process of starch and triglyceride intestinal absorption. The peel extract inhibited both the porcine pancreactic α-amylase and the pancreatic lipase but was 13.6 times more potent on the latter (IC50 values of 1963 and 143.9 μg mL-1, respectively). Cyanidin-3-O-glucoside did n...
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The actions of resveratrol in brain and plasma of rats with adjuvant-induced arthritis were investigated. Resveratrol was administered orally during a period of 23 days. A major concern of the present work was to explore an ample range of daily doses (5 to 200 mg/kg). Several oxidative and inflammatory markers were measured. Important effects of resveratrol treatment were normalization of the plasma myelo-peroxidase activity (inflammatory marker), normalization of the brain xanthine oxidase acti...
1 CitationsSource
Abstract Cerebral ischemia-induced hyperglycemia has been reported to accentuate neurological damage following focal or global cerebral ischemia. Hyperglycemia found in rats following focal brain ischemia occurs in the first 24 hours and has been claimed to be caused by increased liver gluconeogenesis and insulin resistance. However, liver gluconeogenesis and the mechanisms leading to hyperglycemia after global cerebral ischemia remain uncertain. This study investigated the glycemic homeostasis ...
1 CitationsSource
AbstractFish oil (FO) is a natural source of omega-3 fatty acids, with well-established beneficial effects in inflammatory diseases when FO is orally administered. This study investigated the effects of a topically applied FO preparation (FOP) on phenol-induced ear edema and evaluated the percutaneous penetration of FOP in ear tissue. After applying phenol, groups of mice received FOP on the ear. After 1 h, ear tissue was collected to determine the percent inhibition of edema, myeloperoxidase ac...
3 CitationsSource
: Anethole (AN) is a natural compound that has attracted great scientific interest because of its numerous biological activities, including anti-inflammatory effects. However, these effects were obtained with high doses of AN, which may be one limitation of its therapeutic use. This study evaluated the effects of a low-dose AN and ibuprofen (IB) combination on inflammatory parameters in Freund's complete adjuvant-induced arthritis (AIA) and arthritis-induced hepatic metabolic changes. Holtzman r...
1 CitationsSource
#1Alex Graça Contato (USP: University of São Paulo)H-Index: 4
#2Tatiane BrugnariH-Index: 9
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There are different varieties of mushrooms not yet studied spread all over the planet. The objective of this study was to evaluate biochemical properties and effects on mitochondrial respiration of eight Basidiomycete mushrooms: Flaviporus venustus EF30, Hydnopolyporus fimbriatus EF41 and EF44, Inonotus splitgerberi EF46, Oudemansiella canarii EF72, Perenniporia sp. EF79, Phellinus linteus EF81, and Pleurotus albidus EF84. Total phenols, ABTS, TEAC, FRAP, and ORAC were measured in order to deter...
1 CitationsSource
#1Odinei Hess Gonçalves (UTFPR: Federal University of Technology - Paraná)H-Index: 16
#2Thaysa Fernandes Moya Moreira (UTFPR: Federal University of Technology - Paraná)H-Index: 5
Last. Fernanda Vitória Leimann (UTFPR: Federal University of Technology - Paraná)H-Index: 15
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The low water solubility and low bioavailability of natural bioactive substances such as polyphenols and flavonoids, either in pure form or extracts, are a major concern in the pharmaceutical field and even on the food development sector. Although encapsulation has demonstrated success in addressing these drawbacks, it is important to evaluate the antioxidant activity of the encapsulated compounds. This article reviews the encapsulation of bioactive compounds from natural sources focusing their ...
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Methyl jasmonate (MeJA), common in the plant kingdom, is capable of reducing articular and hepatic inflammation and oxidative stress in adjuvant-induced arthritic rats. This study investigated the actions of orally administered MeJA (75–300 mg/kg) on inflammation, oxidative stress and selected enzyme activities in the brain of Holtzman rats with adjuvant-induced arthritis. MeJA prevented the arthritis-induced increased levels of nitrites, nitrates, lipid peroxides, protein carbonyls and reactive...
7 CitationsSource