Lu Wang
Guangzhou University of Chinese Medicine
Insulin receptorAdipogenesisMultiple drug resistanceCytotoxic T cellCarbohydrate metabolismApoptosisIRS1AdipocyteInsulin resistanceP-glycoproteinProstate cancerDihydroartemisininType 2 Diabetes MellitusCell killingDiabetes mellitusMAPK/ERK pathwayProtein kinase BBiologyCancer cellPharmacology
Publications 3
#1Rui-Yi Yang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Lu Wang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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: The present study investigated the effects of cajanonic acid A (CAA), extracted from the leaves of Cajanus cajan (L.) Millsp with a purity of 98.22%, on the regulatory mechanisms of glucose and lipid metabolism. HepG2 cells transfected with a protein‑tyrosine phosphatase 1B (PTP1B) overexpression plasmid were established. The cells, induced with insulin resistance by dexamethasone (Dex) treatment, together with type 2 diabetes mellitus (T2DM) model rats and ob/ob mice, were used in the present...
8 CitationsSource
#1Xiaoling Shen (Guangzhou University of Chinese Medicine)H-Index: 1
#2Guang-Ying Chen (Hainan Normal University)H-Index: 18
Last. Wang-Fun Fong (Hong Kong Baptist University)H-Index: 31
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Objectives P-glycoprotein (Pgp) overexpression in tumour cells leads to multidrug resistance (MDR) and causes failure in cancer chemotherapy. We have previously identified (±)-praeruptorin A (PA) as a potential lead compound for Pgp modulators. In this study we investigated the MDR-reversing activities of PA derivatives. Methods Series 7,8-pyranocoumarins with various C-3′ and C-4′ side chains had been semi-synthesized and their MDR-reversing activity was investigated in Pgp-overexpressing MDR t...
12 CitationsSource
#1Qin He (State University of New York Upstate Medical University)H-Index: 17
#2Jingxue ShiH-Index: 7
Last. Ying HuangH-Index: 40
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Dihydroartemisinin (DHA) is a derivative of artemisinin and is an effective anti-malaria therapeutic used worldwide. In this report, we report that DHA is as a potential anti-cancer drug for prostate cancer. Our data indicate that DHA suppresses the PI3-K/Akt and ERK cell survival pathways and triggers the induction of death receptor DR5 and activation of extrinsic and intrinsic cell death signaling. DHA-mediated DR5 induction appears to occur via increased transcriptional activity of DR5 promot...
83 CitationsSource
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