Yuliya Klymenko
Indiana University
CancerInternal medicineOncologyCellCadherinAdipose tissueChemistryExtracellular matrixMesenchymal stem cellPeritoneumLysophosphatidic acidPeritoneal cavityMetastasisMechanobiologyPrimary tumorOvarian cancerAscitesMesothelial CellCancer researchMedicineBiologyCancer cell
26Publications
8H-index
279Citations
Publications 19
Newest
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
1 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2Rebecca B. Wates (KU: University of Kansas)H-Index: 2
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 10 authors...
ABSTRACT Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to >2 l), resulting in physical discomfort and abdominal distension, ...
9 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Kenneth P. Nephew (IU: Indiana University)H-Index: 74
: Metastatic dissemination of epithelial ovarian cancer (EOC) predominantly occurs through direct cell shedding from the primary tumor into the intra-abdominal cavity that is filled with malignant ascitic effusions. Facilitated by the fluid flow, cells distribute throughout the cavity, broadly seed and invade through peritoneal lining, and resume secondary tumor growth in abdominal and pelvic organs. At all steps of this unique metastatic process, cancer cells exist within a multidimensional tum...
20 CitationsSource
#1Yuliya KlymenkoH-Index: 8
#2Brandi BosH-Index: 1
Last. M. Sharon StackH-Index: 59
view all 8 authors...
Source
#1Yuliya KlymenkoH-Index: 8
#2Rebecca B. WatesH-Index: 2
Last. M. Sharon StackH-Index: 59
view all 9 authors...
Source
#1Elizabeth I. Harper (ND: University of Notre Dame)H-Index: 6
#2Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 14 authors...
Ovarian cancer (OvCa) is the deadliest cancer of the female reproductive system, ranking fifth in overall cancer deaths among women. Unlike the majority of cancers, OvCa metastasizes via diffusion through the peritoneal cavity, resulting in multiple metastatic sites, including the omentum and peritoneum. These metastasizing OvCa cells induce rapid mesothelial cell retraction and readily adhere to the sub-mesothelial collagen of the extracellular matrix. Epidemiologic data identifies age as a sig...
Source
#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Annemarie K. Leonard (ND: University of Notre Dame)H-Index: 2
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 17 authors...
Abstract Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little...
9 CitationsSource
#1Annemarie K. Leonard (ND: University of Notre Dame)H-Index: 2
#2Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 9 authors...
Abstract This chapter highlights methods for visualization and analysis of extracellular matrix (ECM) proteins, with particular emphasis on collagen type I, the most abundant protein in mammals. Protocols described range from advanced imaging of complex in vivo matrices to simple biochemical analysis of individual ECM proteins. The first section of this chapter describes common methods to image ECM components and includes protocols for second harmonic generation, scanning electron microscopy, an...
10 CitationsSource
#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Ryan C. Phan (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 15 authors...
Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer met...
1 CitationsSource