Vijay Lyall
Virginia Commonwealth University
BiophysicsEndocrinologyIntracellular pHTRPV1Taste receptorChemistryStimulationChordaMecamylamineUmamiTRPM5NicotineAmilorideBenzamilApical membraneSodiumBiochemistryEpithelial sodium channelTastePharmacology
51Publications
23H-index
1,526Citations
Publications 50
Newest
#1Mee-Ra RhyuH-Index: 8
#1Mee-Ra RhyuH-Index: 12
Last. Vijay LyallH-Index: 23
view all 2 authors...
1 CitationsSource
#1Mee-Ra RhyuH-Index: 12
#2Yiseul KimH-Index: 9
Last. Vijay LyallH-Index: 23
view all 3 authors...
In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expresse...
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#1Joseph K. Ritter (VCU: Virginia Commonwealth University)H-Index: 23
#2Ashfaq Ahmad (VCU: Virginia Commonwealth University)H-Index: 10
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
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The endocannabinoid, anandamide (AEA), stimulates cannabinoid receptors (CBR) and is enriched in the kidney, especially the renal medulla. AEA infused into the renal outer medulla of mice stimulates urine flow rate and salt excretion. Here we show that these effects are blocked by the CBR Type I (CB1) inverse agonist, rimonabant. Immunohistochemical analysis demonstrated the presence of CB1 in thick ascending limb (TAL) tubules. Western immunoblotting demonstrated the presence of CB1 (52 KDa) in...
Source
#1Mee-Ra RhyuH-Index: 8
#1Mee-Ra RhyuH-Index: 12
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
view all 9 authors...
Kokumi taste substances exemplified by g-glutamyl peptides and Maillard Peptides modulate salt and umami tastes. However, the underlying mechanism for their action has not been delineated. Here, we investigated the effects of a kokumi taste active and inactive peptide fraction (500-10,000 Da) isolated from mature (FIIm) and immature (FIIim) Ganjang, a typical Korean soy sauce, on salt and umami taste responses in humans and rodents. Only FIIm (0.1–1.0%) produced a biphasic effect in rat chorda t...
6 CitationsSource
#1Sunila MahavadiH-Index: 21
#2Ancy D. NalliH-Index: 8
Last. Karnam S. MurthyH-Index: 47
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: In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19, interaction of actin and myosin, and actin polymerization. The present study characterized the signaling mechanisms involved in actin polymerization during initial and sustained muscle contraction in response to muscarinic M3 receptor activation in gastric smooth muscle c...
1 CitationsSource
#1Jie Qian (VCU: Virginia Commonwealth University)H-Index: 9
#2Shobha Mummalaneni (VCU: Virginia Commonwealth University)H-Index: 12
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
view all 7 authors...
In rodents, CHRNs are involved in bitter taste transduction of nicotine and ethanol. Currently, it is not clear if CHRNs are expressed in human taste cells and if they play a role in transducing the bitter taste of nicotine and ethanol or in the synthesis and release of neurohumoral peptides. Accordingly, we investigated the expression and functional role of CHRNs in HBO cells. Using molecular techniques, we demonstrate that a subset of HBO cells express CHRNs that also co-express TRPM5, T1R3 or...
2 CitationsSource
#1Jie Qian (VCU: Virginia Commonwealth University)H-Index: 9
#2Shobha Mummalaneni (VCU: Virginia Commonwealth University)H-Index: 12
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
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Nicotine evokes chorda tympani (CT) taste nerve responses and an aversive behavior in Trpm5 knockout (KO) mice. The agonists and antagonists of nicotinic acetylcholine receptors (nAChRs) modulate neural and behavioral responses to nicotine in wildtype (WT) mice, Trpm5 KO mice and rats. This indicates that nicotine evokes bitter taste by activating a Trpm5-dependent pathway and a Trpm5-independent but nAChR-dependent pathway. Rat CT responses to ethanol are also partially inhibited by nAChR block...
5 CitationsSource
#1Jie Qian (VCU: Virginia Commonwealth University)H-Index: 9
#2Shobha Mummalaneni (VCU: Virginia Commonwealth University)H-Index: 12
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
view all 13 authors...
: During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently, the intracellular signals that regulate the postnatal development of salt taste have not been identified. We investigated the effect of cAMP, a downstream signal for arginine vasopressin (AVP) action, on the postnatal development...
2 CitationsSource
#1Jie Qian (VCU: Virginia Commonwealth University)H-Index: 9
#2Shobha Mummalaneni (VCU: Virginia Commonwealth University)H-Index: 12
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
view all 7 authors...
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol. However, at present it is not clear if nAChRs are expressed in enteroendocrine cells other than beta cells of the pancreas and enterochromaffin cells, and if they play a role in the synthesis and release of neurohumoral peptides. Accordingly, we investigated the expression and functional...
10 CitationsSource
#1John A. DeSimone (VCU: Virginia Commonwealth University)H-Index: 32
#2Tam-Hao T. Phan (VCU: Virginia Commonwealth University)H-Index: 17
Last. Vijay Lyall (VCU: Virginia Commonwealth University)H-Index: 23
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Modulatory effects of pHi and [Ca2+]i on taste receptor cell (TRC) epithelial sodium channel (ENaC) were investigated by monitoring chorda tympani (CT) responses to NaCl and KCl at various lingual voltages, before and after lingual application of ionomycin and with 0–10mM CaCl2 in the stimulus and rinse solutions adjusted to pHo 2.0–9.7. 0.1 and 0.5M KCl responses varied continuously with voltage and were fitted to an apical ion channel kinetic model using the same parameters. ENaC-dependent NaC...
1 CitationsSource