Michelly Cristina Galdioli Pellá
State University of West Paraná
Self-healing hydrogelsNuclear chemistrySolubilityFourier transform infrared spectroscopyControlled releaseChemistryMaterials scienceBiocompatibilityGelatinChondroitin sulfateChitosanDrug deliveryCoatingSurface coatingDifferential scanning calorimetryChemical engineeringPolymerStarchThermogravimetric analysisNanofiber
12Publications
4H-index
228Citations
Publications 13
Newest
#1Lidiane Rodrigues Antunes (UNIOESTE: State University of West Paraná)
#2Gabriela Lauer Breitenbach (UNIOESTE: State University of West Paraná)H-Index: 1
Last. Douglas Cardoso Dragunski (UNIOESTE: State University of West Paraná)H-Index: 15
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Abstract Drug delivery devices are attractive alternatives to drugs usually orally administrated. Therefore, this work aimed to produce PLA/PBAT-based nanofibers for the controlled release of cilostazol, evaluating the effect of different drug concentrations (20 and 30%) over the properties of the fibers. The fibers were characterized by scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), x-ray diffraction (XRD), differential scanning calorimetry (DSC), thermograv...
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#1Bruno Marques Carvalho (UNIOESTE: State University of West Paraná)
Last. Douglas Cardoso Dragunski (UNIOESTE: State University of West Paraná)H-Index: 15
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Abstract Considering the potential application of electrospun nanofibers as drug delivery systems and the advantages of controlled releases of nonsteroidal drugs (e. g. aceclofenac), which are harmful to the gastric system, producing nanofibers based on poly(lactic acid) (PLA) and butylene poly (butylene adipate)-co-(butylene terephthalate) (PBAT) for transdermal release of aceclofenac was the goal of this work. The incorporation of aceclofenac into the nanofibers changed the initial interaction...
1 CitationsSource
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Abstract Magnetic microgels based on chitosan, modified with glycidyl methacrylate (GMA) and activated with folic acid (FA), and cobalt ferrite nanoparticles, modified with GMA (GMACoFe2O4), were synthesized by emulsion polymerization. The size of the round-shaped microgels, with and without GMACoFe2O4, ranged from (1.62 ± 0.38) μm to (1.71 ± 0.61) μm, respectively. Their release behavior was evaluated in the presence and absence of a magnetic field (MF), using vitamin-B12 as a model drug. In th...
3 CitationsSource
#1Gabriela Lauer Breitenbach (UNIOESTE: State University of West Paraná)H-Index: 1
#2Marina Giombelli Rosenberger (UFPR: Federal University of Paraná)H-Index: 1
Last. Douglas Cardoso Dragunski (UNIOESTE: State University of West Paraná)H-Index: 15
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Wound dressings are based on the creation of ideal environments for cell mobility, gas exchanges and to promote tissue healing and regeneration, besides controlling bacterial proliferation. Electrospinning is a simple, cheap and common technique used for such purposes and Ecovio®, a polymeric blend based on biocompatible polymers (poly(butylene adipate-co-terephthalate) (PBAT) and poly(lactic acid) (PLA)), is a good example of polymer with unique properties for wound dressing materials developme...
2 CitationsSource
#1Michelly Cristina Galdioli Pellá (UEM: Universidade Estadual de Maringá)H-Index: 4
Last. Adley F. RubiraH-Index: 40
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Abstract In the present work, hybrid microgels based on chitosan and SiO2 nanoparticles (NPs) were synthesized. Both chitosan and the SiO2 NPs were submitted to chemical modification reactions to having vinyl groups incorporated into their structures. The microgels were synthesized by emulsion polymerization. SEM analysis indicated a high dispersity of diameter for the microgels, ranging between (18.7 ± 12.3) μm for the samples without SiO2-VTS and (11.3 ± 8.07) μm for the microgels with SiO2-VT...
4 CitationsSource
Last. Douglas Cardoso Dragunski (UWO: University of Western Ontario)H-Index: 15
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Abstract Guava is a perishable fruit susceptible to post-harvest losses. So, the development of biodegradable films based on acetylated cassava starch (ACS) and hydroxyethyl cellulose (HEC) could be an alternative to increase guavas (Psidium guajava L.) shelf life. Films were characterized by solubility, opacity, water vapor transport, and thickness. Mass loss, texture, titratable acidity, soluble solids, vitamin C, and skin color of the fruits were analyzed. The films with higher HEC concentrat...
6 CitationsSource
#2Vanessa H. Fragal (State University of Campinas)H-Index: 1
Last. Adley F. RubiraH-Index: 40
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Abstract This study compared the controlled release of two drugs: vitamin-B12, and l -dopa from hydrogels based on 50% of casein (CAS, a protein), 50% of chondroitin sulfate (CS, a polysaccharide) and different amounts of SiO2. The results indicated that the incorporation of 5% of SiO2 to the materials, allowed the best organization, distribution, and diameter of the pores, which are responsible for ensuring a more controlled release. Also, the matrices were not efficient in releasing vitamin-B1...
1 CitationsSource
#1Andressa Renatta Simão (UEM: Universidade Estadual de Maringá)H-Index: 2
#2Vanessa H. Fragal (UEM: Universidade Estadual de Maringá)H-Index: 1
Last. Adley F. Rubira (UEM: Universidade Estadual de Maringá)H-Index: 40
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Abstract In this study, the materials were synthesized by chemically crosslinking chondroitin sulfate (CS), casein (CAS), and silica nanospheres (SiO2), creating a highly crosslinked network. The hydrogel release profile was adaptable (that is, it could be faster or slower as needed) simply by changing the polymeric proportion. The incorporation of 5% of silica nanospheres, in mass, for all CAS/CS matrices promoted a better-controlled and sustained release of l -dopa, focusing on the matrix base...
5 CitationsSource
#1Michelly Cristina Galdioli Pellá (UNIOESTE: State University of West Paraná)H-Index: 4
#2Otavio A. Silva (UNIOESTE: State University of West Paraná)H-Index: 2
Last. Douglas Cardoso Dragunski (UNIOESTE: State University of West Paraná)H-Index: 15
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Abstract Coating fruits surface with biodegradable films obtained from starch is an alternative to delay the fruit ripening process. This study aimed to develop a biodegradable film from a polymer blend consisting of natural cassava starch, casein, and gelatin, and using sorbitol as the plasticizer. Among all the prepared biodegradable films (BFs), the one with desirable results in thickness, opacity, solubility, and water vapor transmission rate (WVTR) analyzes was based on a high concentration...
26 CitationsSource