Barbara K Kemp-Harper
Monash University, Clayton campus
VasodilationInternal medicineEndocrinologyChemistryNitroxylOxidative stressInflammationEndotheliumSoluble guanylyl cyclaseFibrosisMesenteric arteriesSuperoxideEndothelial dysfunctionAngiotensin IINitric oxideBiochemistryDiabetes mellitusRedoxMedicineBiologyPharmacology
Publications 124
#1Tara E. Scott (Monash University, Clayton campus)
#2Chengxue Qin (Monash University, Clayton campus)H-Index: 17
Last. Barbara K Kemp-Harper (DI: Discovery Institute)H-Index: 29
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Pulmonary hypertension is a rare, ostensibly incurable, and etiologically diverse disease with an unacceptably high 5-year mortality rate (≈50%), worse than many cancers. Irrespective of pathogenic...
#1Jordyn Michele Thomas (La Trobe University)
#2Yeong H Ling (Monash University, Clayton campus)H-Index: 1
Last. Barbara K Kemp-Harper (Monash University, Clayton campus)H-Index: 29
view all 19 authors...
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal i...
#1Paul J. White (Monash University)H-Index: 26
#2Elizabeth A. Davis (Monash University, Clayton campus)H-Index: 62
Last. Ian F. Musgrave (University of Adelaide)H-Index: 26
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Pharmacology education currently lacks an agreed knowledge curriculum. Evidence from physics and biology education indicates that core concepts are useful and effective structures around which such a curriculum can be designed to facilitate student learning. Building on previous work, we developed a novel, criterion-based method to identify the core concepts of pharmacology education. Five novel criteria were developed, based on a literature search, to separate core concepts in pharmacology from...
#1Chao Wang (Monash University, Clayton campus)H-Index: 3
#2Tracey Gaspari (Monash University, Clayton campus)H-Index: 17
Last. Chrishan S. Samuel (Monash University, Clayton campus)H-Index: 57
view all 6 authors...
BACKGROUND AND PURPOSE Oxidative stress and fibrosis are hallmarks of cardiomyopathy-induced heart failure, yet are not effectively targeted by current frontline therapies. In this study, the therapeutic effects of the anti-oxidant, N-Acetylcysteine (NAC) were compared, and combined, with the acute heart failure drug with established anti-fibrotic effects, serelaxin (RLX), in a murine model of cardiomyopathy. EXPERIMENTAL APPROACH Adult male 129sv mice were subjected to repeated isoproterenol (I...
#1Joshua P. Dignam (QMUL: Queen Mary University of London)
#2Tara E. Scott (Monash University, Clayton campus)
Last. Adrian J. Hobbs (QMUL: Queen Mary University of London)H-Index: 57
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Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease due to the development of right ventricular (RV) failure. At present, no RV-targeted therapies are available, and RV function is not widely considered in the preclinical assessment of new therapeutics. Several small animal models are used in the study of PH, including the classic models of exposure to either hypoxia or monocrotaline, newer combinational and genetic models, and pulmonary artery banding, a sur...
#1Jasmin Chendi LiH-Index: 1
#2Anida VelagicH-Index: 2
Last. Owen L. Woodman (Monash University)H-Index: 3
view all 8 authors...
Introduction. Endothelial dysfunction is a major risk factor for several of vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one-electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but roles of HNO in diabetes-mellitus associated endothelial dysfunction in the carotid-artery remains unknown. Aim. To assess how diabetes affects roles of endogenous-NO• and-HNO in endothelium-dependent relaxation in rat-isolated car...
#1Chao Wang (Monash University, Clayton campus)H-Index: 3
#2Anita A. Pinar (Monash University, Clayton campus)H-Index: 1
Last. Chrishan S. Samuel (Monash University, Clayton campus)H-Index: 57
view all 8 authors...
Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rapidly occurring anti-fibrotic actions which are mediated through RXFP1 and angiotensin II receptor crosstalk on renal and cardiac myofibroblasts. Here, we investigated whether this would allow relaxin to indirectly activate angiotensin II type 2 receptor (AT2 R)-specific signal transduction in primary human cardiac myofibroblasts (HCMFs). The anti-fibrotic effects of r...
#1Anida Velagic (Monash University)H-Index: 2
#2Chengxue Qin (Monash University)H-Index: 17
Last. Barbara K Kemp-Harper (Monash University)H-Index: 29
view all 6 authors...
Diabetes is associated with an increased mortality risk due to cardiovascular complications. Hyperglycemia-induced oxidative stress underlies these complications, leading to an impairment in endogenous nitric oxide (NO.) generation, together with reductions in NO. bioavailability and NO. responsiveness in the vasculature, platelets and myocardium. The latter impairment of responsiveness to NO., termed NO. resistance, compromises the ability of traditional NO.-based therapeutics to improve hemody...
#1Anita A. Pinar (Monash University)H-Index: 8
#2Tara E. Scott (Monash University)H-Index: 1
Last. Chrishan S. Samuel (Monash University)H-Index: 57
view all 6 authors...
Abstract Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood vessels from an aberrant wound healing response to organ injury or insult. Established fibrosis becomes a hallmark of chronic disease progression and a key contributor to tissue stiffness and dysfunction, which ultimately leads to heart failure. As wound healing and fibrotic responses to myocardial injury are multifactorial processes, current therapies that only target specific contributing fa...
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