Eric Courchesne
University of California, San Diego
AnatomyDevelopmental psychologyMagnetic resonance imagingPsychologyNeuroscienceCognitionCognitive psychologyAutismAutism spectrum disorderDevelopmental disorderFunctional magnetic resonance imagingCerebellumWhite matterBrain mappingAbnormalityElectroencephalographyGeneticsAudiologyMedicineBiology
241Publications
116H-index
36kCitations
Publications 231
Newest
#1Pamela FelicianoH-Index: 5
#2Amy M. DanielsH-Index: 15
Last. Wendy K. ChungH-Index: 83
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The Simons Foundation Autism Research Initiative (SFARI) has launched SPARKForAutism.org, a dynamic platform that is engaging thousands of individuals with autism spectrum disorder (ASD) and connecting them to researchers. By making all data accessible, SPARK seeks to increase our understanding of ASD and accelerate new supports and treatments for ASD.
69 CitationsSource
#1Elizabeth Bacon (UCSD: University of California, San Diego)H-Index: 6
#2Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
Last. Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
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Author(s): Bacon, EC; Courchesne, E; Barnes, CC; Cha, D; Pence, S; Schreibman, L; Stahmer, AC; Pierce, K | Abstract: © 2017 Cambridge University Press. A common theory of autism spectrum disorder (ASD) symptom onset includes toddlers who do not display symptoms until well after age 2, which are termed late-onset ASD cases. Objectives were to analyze differences in clinical phenotype between toddlers identified as ASD at initial evaluations (early diagnosed) versus those initially considered nons...
20 CitationsSource
#1Madeleine R. Geisheker (UW: University of Washington)H-Index: 5
#2Gabriel Heymann (UW: University of Washington)H-Index: 4
Last. Evan E. Eichler (UW: University of Washington)H-Index: 175
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This study characterizes the properties of disease-causing mutations that produce sporadic amino acid replacements in proteins of people with autism and developmental delay. The mutations tend to cluster and reoccur at specific regions important to protein function, highlighting for future follow-up ∼200 candidate genes, many involved in neuronal signaling.
74 CitationsSource
#1Michael V. Lombardo (UCY: University of Cyprus)H-Index: 56
#2Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
Last. Tiziano Pramparo (UCSD: University of California, San Diego)H-Index: 31
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Background Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell cycle, DNA damage, WNT signaling, cortical patterning and differentiation) potentially involved in ASD brain abnormalities during childhood and adulthood. However, it remains unclear whether such diverse dysregulated pathways are independent of each other or instead reflect coor...
17 CitationsSource
#1Maria C. Marchetto (Salk Institute for Biological Studies)H-Index: 47
#2Haim Belinson (UCSF: University of California, San Francisco)H-Index: 11
Last. Alysson R. Muotri (UCSD: University of California, San Diego)H-Index: 58
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Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD pathogenesis have been proposed based on genetic studies, brain pathology and imaging, but a major impediment to testing ASD hypotheses is the lack of human cell models. Here, we reprogrammed fibroblasts to generate induced pluripotent stem cells, neural progenitor cells (NPCs) and neurons from ASD individuals with early brain overgrowth and no...
201 CitationsSource
#1Michael J. McConnell (UVA: University of Virginia)H-Index: 21
#2John V. Moran (UM: University of Michigan)H-Index: 55
Last. Flora M. Vaccarino (Yale University)H-Index: 59
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BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a major scientific and medical challenge. Emerging genomic technologies now permit the analysis of somatic mosaicism in human tissues. The measured frequencies of single-nucleotide variants (SNVs), small insertion/deletion (indel) mutations, structural variants [including copy number variants (CNVs), inversions, translocations, and whole-chromosome gains or losses], and mobile genetic element insertions (MEIs) ...
148 CitationsSource
#1Holly A.F. Stessman (UW: University of Washington)H-Index: 22
#2Bo Xiong (Creighton University)H-Index: 17
Last. Evan E. Eichler (UW: University of Washington)H-Index: 175
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Evan Eichler and colleagues use single-molecule molecular-inversion probes to sequence the coding and splicing regions of 208 candidate genes in more than 11,730 individuals with neurodevelopmental disorders. They report 91 genes with an excess of de novo or private disruptive mutations, identify 25 genes showing a bias for autism versus intellectual disability, and highlight a network associated with high-functioning autism.
239 CitationsSource
#1Noa Fingher (BGU: Ben-Gurion University of the Negev)H-Index: 1
#2Ilan Dinstein (BGU: Ben-Gurion University of the Negev)H-Index: 26
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
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Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in...
26 CitationsSource
#1Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
#2Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
Last. Elizabeth Bacon (UCSD: University of California, San Diego)H-Index: 6
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36 CitationsSource
#1Stephanie Solso (UCSD: University of California, San Diego)H-Index: 5
#2Ronghui Xu (UCSD: University of California, San Diego)H-Index: 27
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
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Abstract Background Theories of brain abnormality in autism spectrum disorder (ASD) have focused on underconnectivity as an explanation for social, language, and behavioral deficits but are based mainly on studies of older autistic children and adults. Methods In 94 ASD and typical toddlers ages 1 to 4 years, we examined the microstructure (indexed by fractional anisotropy) and volume of axon pathways using in vivo diffusion tensor imaging of fronto-frontal, fronto-temporal, fronto-striatal, and...
75 CitationsSource