Yuexin Xu
Nanjing Medical University
Cell cycle checkpointTransactivationNotch signaling pathwayBone remodelingKinaseChemistryApoptosisDU145OsteoporosisOsteoblastHistone deacetylaseJAG1LFNGCell cycleHDAC4Signal transductionProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biology
5Publications
4H-index
48Citations
Publications 5
Newest
#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Dong Li (Nanjing University of Chinese Medicine)H-Index: 1
Last. Wei Zhang (Nanjing Medical University)H-Index: 25
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Osteoporosis is a complex multifactorial disorder characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures or broken bones. Balanced bone remodeling is tightly regulated by the differentiation, activity and apoptosis of bone‑forming osteoblasts and bone‑resorbing osteoclasts. MicroRNAs (miRs) are dysregulated in osteoporosis, but whether they control osteogenic differentiation and skeletal biology, or could serve as therapeutic targets remains to be eluci...
2 CitationsSource
#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Lingyun Li (Nanjing Medical University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Abstract Osteoporosis is a bone disease characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures. Icariin (ICA), an active flavonoid glucoside isolated from Herba epimedii (HEF), is a potent stimulator of osteogenic differentiation and has potential applications for preventing bone loss in postmenopausal women. However, the molecular mechanism underlying the osteogenic effect of ICA has not yet been fully elucidated. In this study, we report that ICA trea...
4 CitationsSource
#1Jianlei Lu (Nanjing Medical University)H-Index: 8
#2Xiang Chen (Jiangsu University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Abstract Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its antitumor effects and underlying mechanisms on prostate cancer cells have not yet been clearly identified. In the present study, the androgen-independent prostate cancer PC3 and DU145 cell lines were used as models to investigate the effects and possible mechanisms of oridonin on cellular proliferation and apo...
19 CitationsSource
#1Jianlei Lu (Nanjing Medical University)H-Index: 8
#2Shuang Qu (Nanjing Medical University)H-Index: 4
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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// Jianlei Lu 1,* , Shuang Qu 1,* , Bing Yao 1,* , Yuexin Xu 1 , Yucui Jin 1 , Kaikai Shi 1 , Yifang Shui 1 , Shiyang Pan 2 , Li Chen 3 and Changyan Ma 1 1 Department of Developmental Genetics, Nanjing Medical University, Nanjing, P.R. China 2 Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China 3 Molecular Endocrinology Laboratory, Department of Endocrinology, Odense University Hospital, Odense C, Denmark * These authors contributed...
19 CitationsSource
#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Bing Yao (Nanjing Medical University)H-Index: 5
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 10 authors...
Osterix (Osx) is an essential regulator for osteoblast differentiation and bone formation. Although phosphorylation has been reported to be involved in the regulation of Osx activity, the precise underlying mechanisms remain to be elucidated. Here we identified S422 as a novel phosphorylation site of Osx and demonstrated that GSK-3β interacted and co-localized with Osx. GSK-3β increased the stability and transactivation activity of Osx through phosphorylation of the newly identified site. These ...
8 CitationsSource
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