Veronica Ruta
Sapienza University of Rome
GerminationPromoterGeneHypocotylAbiotic componentMutantHorticultureLeucine zipperRepressorRegulation of gene expressionVascular tissueEndodermisChemistryWild typeAuxinTranscriptional regulationArabidopsis thalianaSeedlingHistone H3PRC2ArabidopsisAbscisic acidH3K4me3PhotomorphogenesisSkotomorphogenesisAutotrophic organismElongationCortex (botany)DormancyEpigeneticsEZH2BotanyRegulatorControl networkCrosstalk (biology)GibberellinTranscription factorBiologySeed dormancyAbiotic stressPhytochromeCell biology
11Publications
4H-index
72Citations
Publications 8
Newest
#1Gaia BertolottiH-Index: 2
#2Simon J. Unterholzner (Free University of Bozen-Bolzano)H-Index: 7
Last. Raffaele Dello IoioH-Index: 14
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Summary In both animals and plants, development involves anatomical modifications. In the root of Arabidopsis thaliana, maturation of the ground tissue (GT)—a tissue comprising all cells between epidermal and vascular ones—is a paradigmatic example of these modifications, as it generates an additional tissue layer, the middle cortex (MC). 1 , 2 , 3 , 4 In early post-embryonic phases, the Arabidopsis root GT is composed of one layer of endodermis and one of cortex. A second cortex layer, the MC, ...
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#1Chiara LongoH-Index: 3
#2Soyanni HolnessH-Index: 1
Last. Paola VittoriosoH-Index: 13
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The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving both internal and external signals, which lead to a fine-tuning control network. In recent years, numerous studies have contributed to elucidate the molecular mechanisms underlying ...
1 CitationsSource
#1Veronica Ruta (Sapienza University of Rome)H-Index: 4
#2Chiara Longo (Sapienza University of Rome)H-Index: 3
Last. Paola Vittorioso (Sapienza University of Rome)H-Index: 13
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The DOF (DNA binding with one finger) family of plant-specific transcription factors (TF) was first identified in maize in 1995. Since then, DOF proteins have been shown to be present in the whole plant kingdom, including the unicellular alga Chlamydomonas reinhardtii. The DOF TF family is characterised by a highly conserved DNA binding domain (DOF domain), consisting of a CX2C-X21-CX2C motif, which is able to form a zinc finger structure. Early in the study of DOF proteins, their relevance for ...
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#1Veronica RutaH-Index: 4
#2Chiara LongoH-Index: 3
Last. Paola VittoriosoH-Index: 13
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Polycomb repressive complex 2 (PRC2) is an epigenetic transcriptional repression system, whose catalytic subunit (ENHANCER OF ZESTE HOMOLOG 2, EZH2 in animals) is responsible for trimethylating histone H3 at lysine 27 (H3K27me3). In mammals, gain-of-function mutations as well as overexpression of EZH2 have been associated with several tumors, therefore making this subunit a suitable target for the development of selective inhibitors. Indeed, highly specific small-molecule inhibitors of EZH2 have...
4 CitationsSource
#1Riccardo Lorrai (Sapienza University of Rome)H-Index: 6
#2Francesco Gandolfi (University of Trento)H-Index: 2
Last. Paola Vittorioso (Sapienza University of Rome)H-Index: 13
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Hypocotyl elongation is influenced by light and hormones, but the molecular mechanisms underlying this process are not yet fully elucidated. We had previously suggested that the Arabidopsis DOF transcription factor DAG1 may be a negative component of the mechanism of light-mediated inhibition of hypocotyl elongation, as light-grown dag1 knock-out mutant seedlings show significant shorter hypocotyls than the wild type. By using high-throughput RNA-seq, we compared the transcriptome profile of dag...
7 CitationsSource
#1Riccardo Lorrai (Sapienza University of Rome)H-Index: 6
#2Alessandra Boccaccini (Sapienza University of Rome)H-Index: 7
Last. Paola Vittorioso (Sapienza University of Rome)H-Index: 13
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: Hypocotyl elongation of Arabidopsis seedlings is influenced by light and numerous growth factors. Light induces inhibition of hypocotyl elongation (photomorphogenesis), whereas in the dark hypocotyl elongation is promoted (skotomorphogenesis). Abscisic acid (ABA) plays a major role in inhibition of hypocotyl elongation, but the molecular mechanism remains unclear. We investigated the effect of ABA during photo- and skotomorphogenesis, making use of appropriate mutants, and we show that ABA neg...
16 CitationsSource
#2Riccardo LorraiH-Index: 6
Last. Paola VittoriosoH-Index: 13
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Background In seeds, the transition from dormancy to germination is regulated by abscisic acid (ABA) and gibberellins (GAs), and involves chromatin remodelling. Particularly, the repressive mark H3K27 trimethylation (H3K27me3) has been shown to target many master regulators of this transition. DAG1 (DOF AFFECTING GERMINATION1), is a negative regulator of seed germination in Arabidopsis, and directly represses the GA biosynthetic gene GA3ox1 (gibberellin 3-β-dioxygenase 1). We set to investigate ...
16 CitationsSource
#1Silvia SantopoloH-Index: 3
Last. Paola VittoriosoH-Index: 13
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Background The transcription factor DOF AFFECTING GERMINATION1 (DAG1) is a repressor of the light-mediated seed germination process. DAG1 acts downstream PHYTOCHROME INTERACTING FACTOR3-LIKE 5 (PIL5), the master repressor, and negatively regulates gibberellin biosynthesis by directly repressing the biosynthetic gene AtGA3ox1. The Dof protein DOF AFFECTING GERMINATION (DAG2) shares a high degree of aminoacidic identity with DAG1. While DAG1 inactivation considerably increases the germination capa...
25 CitationsSource