Vera S. Donnenberg
University of Pittsburgh
CD34CD90CancerInternal medicinePathologyAntigenMolecular biologyCD8Stromal cellAdipose tissueMesenchymal stem cellProgenitor cellImmunologyBone marrowCytometryStem cellCancer researchFlow cytometryCancer stem cellMedicineBiologyImmune systemCell biologyCancer cell
Publications 99
#1Debra A. Bourne (University of Pittsburgh)H-Index: 6
#2Jacqueline M. Bliley (University of Pittsburgh)H-Index: 12
Last. J. Peter RubinH-Index: 60
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OBJECTIVE: This study aimed to prospectively assess outcomes for surgical autologous fat transfer (AFT) applied for traumatic and postsurgical craniofacial deformities. The minimally invasive nature of AFT has potential for reduced risk and superior outcomes compared with current reconstructive options. BACKGROUND: Craniofacial deformities have functional and psychosocial sequelae and can profoundly affect quality of life. Traditional reconstructive options are invasive, invasive, complex, and o...
2 CitationsSource
#1Marie-Nicole Theodoraki (University of Pittsburgh)H-Index: 10
#1Marie-Nicole Theodoraki (University of Pittsburgh)H-Index: 13
Last. Theresa L. WhitesideH-Index: 129
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Exosomes, recently re-named "small extracellular vesicles" or "sEV," are emerging as an intercellular communication system. Quantification of the molecular cargo exosomes carry by on-bead flow cytometry is needed for defining their role in information transfer and in human disease. Exosomes (sEV) isolated from cell supernatants or plasma of cancer patients by size-exclusion chromatography were captured by biotinylated antibodies specific for antigens in the exosome cargo (e.g., tetraspanins) and...
4 CitationsSource
1 CitationsSource
#1Vaishali Aggarwal (University of Pittsburgh)H-Index: 10
#2Catalina Ardila Montoya (University of Pittsburgh)
Last. Shilpa SantH-Index: 27
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Summary Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has been extensively studied to address the unresolved variable treatment response across therapeutic regimes in cancer subtypes. EMT has long been envisaged to regulate tumor invasion, migration, and therapeutic resistance during tumorigenesis. However, recently it has been highlighted that EMT involves an intermediate partial EMT (pEMT) phenotype, defined by incomplete loss of epithelial markers and incom...
#1Albert D. Donnenberg (University of Pittsburgh)H-Index: 27
#2James D. Luketich (University of Pittsburgh)H-Index: 97
Last. Vera S. Donnenberg (University of Pittsburgh)H-Index: 28
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// Albert D. Donnenberg 1 , 2 , 3 , James D. Luketich 2 , 4 and Vera S. Donnenberg 2 , 3 , 4 1 University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA 2 UPMC Hillman Cancer Centers, Pittsburgh, PA, USA 3 McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA 4 University of Pittsburgh School of Medicine, Department of Cardiothoracic Surgery, Pittsburgh, PA, USA Correspondence to: Albert D. Donnenberg, email: Vera S. Donnenberg, ema...
1 CitationsSource
#1Vera S. DonnenbergH-Index: 28
#2Philip Chaikin (American College of Clinical Pharmacology)H-Index: 1
Last. James F. Burris (American College of Clinical Pharmacology)H-Index: 14
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: Although the medical profession strives for safe prescribing, most medications are unique challenges even when prescribed by an experienced provider. In this article we discuss the pitfalls associated with drug interactions between commonly used antibiotics and anticoagulants, the complexities associated with the administration of novel reversible anticoagulants, the often-overlooked severe adverse drug reactions from commonly used classes of medications such as corticosteroids, the nuances of...
1 CitationsSource
#1Manjulata Singh (University of Pittsburgh)H-Index: 8
#2Xiao-Jun Tian (University of Pittsburgh)H-Index: 14
Last. Shilpa Sant (University of Pittsburgh)H-Index: 27
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Targeting microenvironmental factors that foster migratory cell phenotypes is a promising strategy for halting tumor migration. However, lack of mechanistic understanding of the emergence of migratory phenotypes impedes pharmaceutical drug development. Using our 3D microtumor model with tight control over tumor size, we recapitulated the tumor size-induced hypoxic microenvironment and emergence of migratory phenotypes in microtumors from epithelial breast cells and patient-derived primary metast...
9 CitationsSource
#1Albert D. Donnenberg (University of Pittsburgh)H-Index: 27
#2James D. Luketich (University of Pittsburgh)H-Index: 97
Last. Vera S. Donnenberg (University of Pittsburgh)H-Index: 28
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Malignant pleural effusions (MPE) are a common terminal pathway for many cancers, with an estimated United States incidence of more than 150,000 cases per year. MPE is an aggressive disease with a uniformly fatal prognosis and a life expectancy of only 3 to 12 months. The development of an effective targeted therapy represents a pressing unmet need. This commentary focuses on how cellular and humoral components condition the pleural space as a tumor-promoting, wound-healing environment. Despite ...
5 CitationsSource