Yanyu Xiao
China Pharmaceutical University
CytotoxicityMicellePharmacokineticsBiophysicsDrug carrierNuclear chemistryBioavailabilityNanocarriersLiposomeChemistryConjugateIn vitroIn vivoOral administrationHyaluronic acidBiodistributionCurcuminChitosanDrug deliveryChromatographyPermeationPEG ratioBiochemistryZeta potentialBovine serum albuminPharmacology
67Publications
22H-index
1,225Citations
Publications 66
Newest
#1Shanshan Zhang (ZJNU: Zhejiang Chinese Medical University)
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 10 authors...
Targeting a single molecule or a single pathway and poor drug delivery to the brain hamper the therapy of Alzheimer's disease (AD) based on abnormal metabolism of amyloid-β (Aβ). To solve these problems, we designed and synthesized a multi - strategy peptide (MOP), an ingenious apolipoprotein E mimetic peptide, which could reduce Aβ deposition via inhibiting Aβ aggregation and at the same time accelerate Aβ clearance. Meanwhile, MOP could be self-assembled into different nanostructure, thus we c...
Source
#1Ling Lin (CPU: China Pharmaceutical University)H-Index: 1
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 8 authors...
OBJECTIVE This study was aimed at improving the water solubility and oral bioavailability of Chl by self-microemulsifying drug delivery system (Chl-SMEDDS). METHODS Compatibility experiments, pseudo-ternary phase diagram and central composite design were used to optimize the formulation. The selected systems were further evaluated for physical characteristics, including particle size, zeta potential, and appearance. The stability, in vitro dispersion test, and in vivo intestinal perfusion experi...
Source
#1Mei Zhang (CPU: China Pharmaceutical University)H-Index: 4
#1Mei Zhang (CPU: China Pharmaceutical University)H-Index: 6
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 8 authors...
Abstract Herein, lactoferrin (Lf)/phenylboronic acid (PBA)-functionalized hyaluronic acid nanogels crosslinked with disulfide-bond crosslinker was developed as a reduction-sensitive dual-targeting glioma therapeutic platform for doxorubicin hydrochloride (DOX) delivery (Lf-DOX/PBNG). Spherical Lf-DOX/PBNG with optimized physicochemical properties was obtained, and it could rapidly release the encapsulated DOX under high glutathione concentration. Moreover, enhanced cytotoxicity, superior cellula...
4 CitationsSource
#1Shanshan Zhang (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
#1Shan-Shan Zhang (ZJNU: Zhejiang Chinese Medical University)
Last. Yanyu XiaoH-Index: 22
view all 8 authors...
Fungal infections of the central nervous system (CNS) may lead to life-threatening meningitis. Itraconazole (ITZ) is an effective antifungal agent that can be used to treat various fungal infections; however, its poor solubility along with poor permeability of the blood-brain barrier (BBB) prevents it from treating meningitis. Receptor mediated transcytosis (RMT) shows modest efficacy in BBB crossing, while affinity and saturability of interactions between ligands and receptors account for the l...
2 CitationsSource
#1Shanshan Zhang (CPU: China Pharmaceutical University)H-Index: 2
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 8 authors...
Abstract To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constructed a nano delivery system to evaluate the effect of N-acetyl-L-cysteine (NAC) on intestinal absorption and oral bioavailability of CUR. CUR was first encapsulated in bovine serum albumin nanoparticles (CUR-BSA-NPs), and then was further modified by NAC (CUR-NBSA-NPs). In situ single-pass intestinal perfusion assay demonstrated that CUR-NBSA-NPs displayed excell...
2 CitationsSource
#1Kambere Amerigos Daddy J.C. (CPU: China Pharmaceutical University)H-Index: 3
#2Minglei Chen (CPU: China Pharmaceutical University)H-Index: 9
Last. Qineng Ping (CPU: China Pharmaceutical University)H-Index: 45
view all 6 authors...
Multidrug resistance (MDR) due to P-glycoprotein (P-gp) overexpression is a major obstacle to successful leukemia chemotherapy. The combination of anticancer chemotherapy with a chemosensitizer of P-gp inhibitor is promising to overcome MDR, generate synergistic effects, and maximize the treatment effect. Herein, we co-encapsulated a chemotherapeutic drug of mitoxantrone (MTO) and a P-gp inhibitor of β-elemene (βE) in solid lipid nanoparticles (MTO/βE-SLNs) for reversing MDR in leukemia. The MTO...
5 CitationsSource
#1Shanshan Zhang (CPU: China Pharmaceutical University)H-Index: 2
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 7 authors...
Abstract Itraconazole (ITZ) can be used for the treatment of cryptococcus neoformans meningitis and aspergillus brain abscess. While, the inherent hydrophobicity of ITZ and the existence of blood brain barrier (BBB) limit its applications as a central nervous system drug. In this study, a novel brain targeting drug delivery system based on bovine serum albumin (BSA) was constructed for enhancing ITZ distribution in brain. Firstly, ITZ was loaded into BSA nanoparticles (ITZ-NPs) with 11.6 % of dr...
6 CitationsSource
#1Minglei Chen (CPU: China Pharmaceutical University)H-Index: 9
#2Kambere Amerigos Daddy J.C. (CPU: China Pharmaceutical University)H-Index: 3
Last. Qineng Ping (CPU: China Pharmaceutical University)H-Index: 45
view all 7 authors...
Multifunctional nanomedicines with active targeting and stimuli-responsive drug release function utilizing pathophysiological features of the disease are regarded as an effective strategy for treatment of rheumatoid arthritis (RA). Under the inflammatory environment of RA, activated macrophages revealed increased expression of folate receptor and elevated intracellular reactive oxygen species (ROS) level. In this study, we successfully conjugated folate to polyethylene glycol 100 monostearate as...
10 CitationsSource
#1Mei Zhang (CPU: China Pharmaceutical University)H-Index: 4
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 8 authors...
Abstract A micelle system based on hyaluronic acid (HA)-octadecylamine (OA) conjugate (HOA) functionalized with N-acetylcysteine (NAC) was constructed to yield NAC modified HOA conjugate (NHOA) for improving oral paclitaxel (PTX) delivery (PTX-NHOA). The average size of spherical PTX-NHOA micelles was 162.7 nm with a zeta potential of −27.6 mv. The encapsulation efficiency (EE) and drug loading (DL) of PTX-NHOA micelles were 92.64% and 6.96%, respectively. Additionally, NHOA micelles exihibited ...
7 CitationsSource
#1Cihui Tian (CPU: China Pharmaceutical University)H-Index: 5
#2Sajid Asghar (GCUF: Government College University, Faisalabad)H-Index: 16
Last. Yanyu Xiao (CPU: China Pharmaceutical University)H-Index: 22
view all 7 authors...
Abstract The gliomas treatment is challenging due to the limits imposed by blood-brain barrier to the distribution of the drugs in the brain. Therefore, we designed a brain glioma targeting redox-sensitive hyaluronic acid (HA)-ss-curcumin (CUR) micelles. HA was conjugated to CUR through a disulfide bond, which could form micelles independently in aqueous solution. And we further increased the drug loading by loading free CUR. Brain penetration was achieved with Tween 80, whereas glioma-targeting...
6 CitationsSource