Ern Yu Tan
Tan Tock Seng Hospital
Drug resistanceCancerInternal medicineRadiologySurgeryOncologySpheroidStage (cooking)ChemistryMetastatic breast cancerBiopsyChemotherapyPaclitaxelMastectomyMetastasisDiseaseDengue virusTriple-negative breast cancerSentinel lymph nodePopulationGynecologyCancer researchRadiation therapyBreast cancerMedicineBiologyImmune system
Publications 70
#2Ern Yu TanH-Index: 17
Last. Niketa Chotai (TTSH: Tan Tock Seng Hospital)H-Index: 4
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#1Chi Lok Wong (Agency for Science, Technology and Research)H-Index: 15
#2Sau Yeen LokeH-Index: 7
Last. Malini Olivo (Agency for Science, Technology and Research)H-Index: 59
view all 9 authors...
In this paper, we report for the first time, the detection of circulating miRNA as a breast cancer biomarker in patient sera using surface plasmon resonance imaging biosensor. The advantage of this approach lies in the rapid, label-free and sensitive detection. The sensor excites plasmonic resonance on the gold sensor surface and specific DNA-miRNA molecular bindings elucidate responses in the plasmonic resonance image. The physical resonance condition is only satisfied with p-polarized light, w...
#1Ee Ling Serene Tang (TTSH: Tan Tock Seng Hospital)H-Index: 1
#2Chi Shern Bernard Ho (TTSH: Tan Tock Seng Hospital)H-Index: 1
Last. Ern Yu Tan (TTSH: Tan Tock Seng Hospital)H-Index: 17
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INTRODUCTION Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This study aims to evaluate effective treatment modalities, as well as understand the demographics and clinical presentation of patients with IGM. METHODS An 11-year retrospective review was performed of patients diagnosed with IGM from 1 January 2008 to 3...
#2Peh Joo Ho (Genome Institute of Singapore)H-Index: 8
Last. Mikael HartmanH-Index: 45
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#7Preetha Madhukumar (NUS: National University of Singapore)H-Index: 6
Mammography is extensively used for breast cancer screening but has high false-positive rates. Here, prospectively collected blood samples were used to identify circulating microRNA (miRNA) biomarkers to discriminate between malignant and benign breast lesions among women with abnormal mammograms. The Discovery cohort comprised 72 patients with breast cancer and 197 patients with benign breast lesions, while the Validation cohort had 73 and 196 cancer and benign cases, respectively. Absolute exp...
#3Hui Miao (NUS: National University of Singapore)H-Index: 4
#4Swee Ho Lim (NUS: National University of Singapore)H-Index: 4
Last. Wei Sean Yong (NUS: National University of Singapore)H-Index: 7
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This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer ca...
#1Pei Sze Ng (UM: University of Malaya)H-Index: 2
#2Rick A Boonen (LUMC: Leiden University Medical Center)H-Index: 3
Last. Soo Hwang Teo (UM: University of Malaya)H-Index: 53
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BACKGROUND Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here, we describe the prevalence of rare variants in PALB2 in a population-based study of 7840 breast cancer cases and 7928 healthy Chinese, Malay and Indian women from Malaysia and Singapore, and describe the functional impact of germline missense variants identified in this p...
#1Peh Joo Ho (Genome Institute of Singapore)H-Index: 8
#2Rajkumar Dorajoo (Genome Institute of Singapore)H-Index: 26
Last. Jingmei Li (Genome Institute of Singapore)H-Index: 49
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BACKGROUND A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants. METHODS Genome-wide methylomic variation was quantified (MethylationEPIC) in Asian breast cancer patients (1152 buffy coats from peripheral whole blood). DNA methylation (DNAm) quantitative trait loci (mQTL) mapping was perfo...
#2Geraldine Giap Ying Chiew (NTU: Nanyang Technological University)H-Index: 6
#3Valentin Melnikov (NTU: Nanyang Technological University)H-Index: 5
Last. Peter M. A. Sloot (NTU: Nanyang Technological University)H-Index: 56
view all 7 authors...
The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from variations in mechanisms of cell-drug interactions. 3D spheroids of HeLa-C3 cells were treated with drugs, cisplatin and paclitaxel. This was followed by sectioning and staining of the spheroids to track the spa...
#1Ee Ling Serene Tang (TTSH: Tan Tock Seng Hospital)H-Index: 1
#2Pei Yi Sin (TTSH: Tan Tock Seng Hospital)H-Index: 1
Last. Ern Yu Tan (TTSH: Tan Tock Seng Hospital)H-Index: 17
view all 8 authors...
Introduction Advanced breast cancer (ABC) remains common in Singapore. In 2019, 22.1% of breast cancer patients presented with ABC in our institution. Despite increasing affluence and the advent of national mammographic screening, the incidence of ABC has not changed significantly. This suggests inherent differences in women who present late. We aim to explore the socio-economic background, knowledge and attitudes of women who present with ABC. Methods Between December 2013 and July 2015, 100 pa...
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