Matthias W. Laschke
Saarland University
Internal medicineMicrocirculationBiomedical engineeringPathologyFluorescence microscopeAdipose tissueChemistryImmunohistochemistryIn vivoInflammationNeovascularizationAngiogenesisTransplantationTissue engineeringCancer researchHistologyMedicineBiologyCell biologyPharmacology
Publications 261
#1Tobias Fritz (Saarland University)H-Index: 5
#2Julia Schäfer (Saarland University)
Last. Marcel Orth (Saarland University)H-Index: 5
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Abstract null null Tendon injuries are accounted for up to 50% of musculoskeletal injuries and often result in poor outcomes. Inflammation is a major hallmark of tendon regeneration. Therefore, we analyzed in this study whether the topical application of the pro-inflammatory mediator macrophage-activating lipoprotein (MALP)-2 improves the healing of partial tendon injuries. C57BL/6 mice underwent a partial tenotomy of the flexor digitorum longus tendon of the left hind limb, which was treated wi...
#1Maximilian M. Menger (Saarland University)H-Index: 4
#2Matthias W. Laschke (Saarland University)H-Index: 52
Last. Ahsan Raza (Saarland University)H-Index: 3
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The failure of fracture healing represents a substantial clinical problem. Moreover, aged patients demonstrate an elevated risk for failed bone healing. However, murine models to study the failure of fracture healing are established only in young adult animals. Therefore, the aim of this study was to develop a reliable model to study failed fracture healing in aged mice. After creation of a 1.8 mm segmental defect and periosteal resection, femora of aged mice (18-20 months) and young adult contr...
#1Frederike Nordmeier (Saarland University)H-Index: 3
#2Iryna Sihinevich (Saarland University)
Last. Nadine Schaefer (Saarland University)H-Index: 7
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New synthetic opioids (NSOs) pose a public health concern since their emergence on the illicit drug market and are gaining increasing importance in forensic toxicology. Like many other new psychoactive substances, NSOs are consumed without any preclinical safety data or any knowledge on toxicokinetic (TK) data. Due to ethical reasons, controlled human TK studies cannot be performed for the assessment of these relevant data. As an alternative animal experimental approach, six pigs per drug receiv...
#1Thomas Später (Saarland University)H-Index: 8
#2Julia E. Marschall (Saarland University)
Last. Matthias W. Laschke (Saarland University)H-Index: 52
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Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental studies in rodents exclusively use epididymal adipose tissue as a visceral fat source for MVF isolation. However, in future clinical practice, MVF may be rather isolated from liposuctioned subcutaneous fat tissue of patients. Therefore, we herein compared the vascularization characteristics of MVF isolates from visceral and subcutaneous fat tissue of murine ori...
#1Tobias M. Backes (Saarland University)H-Index: 3
#2Daniel S. Langfermann (Saarland University)H-Index: 3
Last. Gerald Thiel (Saarland University)H-Index: 44
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Cav1.2 L-type voltage-gated Ca2+ channels play a central role in pancreatic β-cells by integrating extracellular signals with intracellular signaling events leading to insulin secretion and altered gene transcription. Here, we investigated the intracellular signaling pathway following stimulation of Cav1.2 Ca2+ channels and addressed the function of the transcription factor activator protein-1 (AP-1) in pancreatic β-cells of transgenic mice. Stimulation of Cav1.2 Ca2+ channels activates AP-1 in ...
#1Lisa Nalbach (Saarland University)H-Index: 4
#2Danièle Müller (Saarland University)
Last. Emmanuel Ampofo (Saarland University)H-Index: 11
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Adipose tissue-derived microvascular fragments (MVF) serve as vascularization units in tissue engineering and regenerative medicine. Because a three-dimensional cellular arrangement has been shown ...
#1Matthias W. Laschke (Saarland University)H-Index: 52
#2Michael D. Menger (Saarland University)H-Index: 91
Tissue regeneration is crucially dependent on sufficient vascularization. In regenerative medicine, this can be effectively achieved by autologous vascularization strategies using the body's own resources. These strategies include the administration of blood-derived factor preparations, adipose tissue-based vascularization, and the in situ engineering of vascularized tissue. Due to their simplicity, the translation of these strategies into clinical practice is easier in terms of feasibility, saf...
#1Jan M. Federspiel (Saarland University)H-Index: 3
#2Philipp A. Schnabel (Saarland University)H-Index: 53
Last. Hans-Joachim Schäfers (Saarland University)H-Index: 69
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OBJECTIVES The unicuspid aortic valve (UAV) is a rare cardiac malformation and is associated with the formation of ascending aortic aneurysms. To characterize its associated aortic wall changes, normal and aneurysmatic ascending aortic wall specimens were analysed, focusing on the potential mechanisms of aneurysm formation. Patients with tricuspid aortic valve (TAV) served as controls. METHODS In a retrospective observational study, 74 specimens (dilated and non-dilated aortas; individuals with ...
1 CitationsSource
#1Maximilian M. Menger (Saarland University)H-Index: 4
#2Lisa Nalbach (Saarland University)H-Index: 4
Last. Emmanuel Ampofo (Saarland University)H-Index: 11
view all 8 authors...
#1Jeannette Rudzitis-Auth (Saarland University)H-Index: 8
#2Anika Christoffel (Saarland University)
Last. Matthias W. Laschke (Saarland University)H-Index: 52
view all 4 authors...
Background and purpose null Limited evidence suggests that the sphingosine-1-phosphate/sphingosine kinase 1 (S1P/SPHK1) signaling pathway is involved in the pathogenesis of endometriosis. Therefore, we analyzed in this study whether the inhibition of SPHK1 and, consequently, the reduction of S1P affects the vascularization and growth of endometriotic lesions. null Experimental approach null Endometriotic lesions were surgically induced in the peritoneal cavity and the dorsal skinfold chamber of ...