Maria C. Cid
University of Barcelona
Endothelial stem cellInternal medicineRadiologySurgeryPathologyImmunologyPlaceboBiopsyVasculitisGiant cell arteritisInflammationTocilizumabSystemic vasculitisPrednisoneDiseasePolymyalgia rheumaticaAngiogenesisArteritisIn patientCancer researchMedicineBiologyGastroenterology
Publications 255
#1Elio G. Carmona (CSIC: Spanish National Research Council)H-Index: 1
#2Jose A García-Giménez (CSIC: Spanish National Research Council)H-Index: 1
Last. Ana Márquez (CSIC: Spanish National Research Council)H-Index: 20
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Objectives Combination of genomic data of different pathologies as a single phenotype has emerged as a useful strategy to identify genetic risk loci shared among immune-mediated diseases. Our study aimed to increase our knowledge of the genetic contribution to Kawasaki disease (kDa) and IgA vasculitis (IgAV) by performing the first comprehensive large-scale analysis on the genetic overlap between both pediatric vasculitis. Methods A total of 1,190 vasculitis patients and 11 302 healthy controls ...
1 CitationsSource
#1John H. Stone (Harvard University)H-Index: 94
#2Jian Han (Genentech)H-Index: 3
Last. Min Bao (Genentech)H-Index: 11
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Summary Background The combination of tocilizumab plus a glucocorticoid taper is effective in maintaining clinical remission without requiring additional glucocorticoid therapy in patients with giant cell arteritis, as shown in part one of the Giant Cell Arteritis Actemra (GiACTA) trial. However, the duration of the tocilizumab effect after discontinuation is unknown. Here, we explored the maintenance of efficacy 1 year after discontinuation of tocilizumab treatment, the effectiveness of retreat...
1 CitationsSource
#1Juan G. ValeroH-Index: 8
#2Alba Matas-Céspedes (AstraZeneca)H-Index: 7
Last. Patricia Pérez-GalánH-Index: 16
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Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival with macrophages playing a controversial role. In the present study, using FL primary samples and HK follicular dendritic cells (FDC) to mimic the germinal center, together with mouse models, we have analyzed the three-way crosstalk of FL-FDC-macrophages and derived therapeutic opportunities. Ex vivo primary FL-FDC co-cultures (n = 19) and in vivo mouse co-xenografts demonstrated that FL-FDC crosstalk favo...
#1Juan Camilo Sarmiento-Monroy (University of Barcelona)H-Index: 2
#2Gerard Espinosa (University of Barcelona)H-Index: 67
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Abstract Background and aim There is increasing interest regarding SARS-CoV-2 infection in patients with autoimmune and immune-mediated inflammatory diseases (AI/IMID) with some discrepancies in different cohorts about their risk and outcomes. The aim was to describe a multidisciplinary cohort of patients with AI/IMID and symptomatic SARS-CoV-2 infection in a single tertiary center and analyze sociodemographic, clinical, and therapeutic factors associated with poor outcomes. Methods A retrospect...
#1Neus SerratH-Index: 2
Last. Patricia Pérez-GalánH-Index: 16
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Despite idelalisib approval in relapsed follicular lymphoma (FL), a complete characterization of the immunomodulatory consequences of phosphatidylinositol 3-kinase δ (PI3Kδ) inhibition, biomarkers of response, and potential combinatorial therapies in FL remain to be established. Using ex vivo cocultures of FL patient biopsies and follicular dendritic cells (FDCs) to mimic the germinal center (n = 42), we uncovered that PI3Kδ inhibition interferes with FDC-induced genes related to angiogenesis, e...
5 CitationsSource
#1Helena Florez (University of Barcelona)H-Index: 4
#2José Hernández-Rodríguez (University of Barcelona)H-Index: 39
Last. Pilar Peris (University of Barcelona)H-Index: 36
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Objective The aim of this study was to identify the risk factors associated with fragility fracture (FF) development in glucocorticoid (GC)-treated patients. Methods 127 patients (aged 62±18 years, 63% women) on GC-treatment (mean dose 14.5±14.1 mg/day and duration 47.7±69 months) were included. The clinical data collected included bone metabolism study (including gonadal axis), GC-treatment, disease activity, dual-energy X-ray absorptiometry analysis (evaluating densitometric osteoporosis (OP) ...
#1Manuel Ehling (Katholieke Universiteit Leuven)H-Index: 4
#2Ward Celus (Katholieke Universiteit Leuven)H-Index: 2
Last. Massimiliano Mazzone (Katholieke Universiteit Leuven)H-Index: 56
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Rationale: How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. Yet, mechanisms underlying vascular remodeling remain poorly established. A better understanding of these processes may lead to the design of novel therapeutic strategies complementary to current angiogenesis inhibitors. Objective: Starting from our previous observations that the PP2A phosphatase regulates the HIF/PHD2-constituted oxygen machinery, we hypothesized that this axis coul...
2 CitationsSource
#1John H. StoneH-Index: 94
#2Thomas NeumannH-Index: 21
Last. Min BaoH-Index: 11
view all 13 authors...