Margaret Gatz
University of Southern California
PsychiatryInternal medicineMental healthDevelopmental psychologyDemographyPsychologyHeritabilityTwin studyCognitionDepression (differential diagnoses)DiseaseDementiaBody mass indexPopulationAlzheimer's diseaseRisk factorClinical psychologyMedicineGerontologyBiology
408Publications
96H-index
18.8kCitations
Publications 404
Newest
#1Diana Younan (SC: University of Southern California)H-Index: 7
#2Xinhui Wang (SC: University of Southern California)H-Index: 16
Last. Lorena Garcia (UC Davis: University of California, Davis)H-Index: 20
view all 16 authors...
BACKGROUND Whether racial/ethnic disparities in Alzheimer's disease (AD) risk may be explained by ambient fine particles (PM2.5) has not been studied. METHODS We conducted a prospective, population-based study on a cohort of Black (n=481) and White (n=6004) older women (aged 65-79) without dementia at enrollment (1995-98). Cox models accounting for competing risk were used to estimate the hazard ratio (HR) for racial/ethnic disparities in AD (1996-2010) defined by DSM-IV and the association with...
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#1Andrei Irimia (SC: University of Southern California)H-Index: 25
#2Nikhil N. Chaudhari (SC: University of Southern California)H-Index: 1
Last. Hillard Kaplan (Chapman University)H-Index: 72
view all 29 authors...
Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. Despite a high infectious disease burden, Tsimane forager-horticulturists of Bolivia have the lowest prevalence of coronary atherosclerosis of any studied population and present few cardiovascular disease (CVD) risk factors despite a high burden of infections and therefore inflammation. This study (A) examines the statistical association between brain volume and age for Tsimane, and (B) compares this...
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#1Thalida E. Arpawong (SC: University of Southern California)H-Index: 10
#2Krisztina Mekli (University of Manchester)H-Index: 6
Last. Carol A. Prescott (SC: University of Southern California)H-Index: 85
view all 6 authors...
Objectives: We evaluated whether the effects of recent stressful life events (SLEs) and early childhood adversities (ECAs) on depressive symptoms are consistent between men and women and across older age, and whether there was evidence for the following: stress sensitization, whereby the psychological impact of SLEs is greater for individuals with ECAs compared with those without; or stress proliferation effect, whereby those with ECAs are more likely to report more SLEs than those without ECAs ...
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#1Ida K. Karlsson (KI: Karolinska Institutet)H-Index: 14
#2Margaret Gatz (SC: University of Southern California)H-Index: 96
Last. Chandra A. Reynolds (UCR: University of California, Riverside)H-Index: 60
view all 5 authors...
Body mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differences and genetic predisposition to higher BMI. We used data from 23,892 individuals of European ancestry from the Health and Retirement Study, with longitudinal data on BMI and three established cognitive indices: mental status, episodic memory, and their sum...
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#1Diana YounanH-Index: 7
#2Xinhui WangH-Index: 16
Last. Jiu-Chiuan ChenH-Index: 32
view all 21 authors...
Objective To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters Methods AD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the Alzheimer’s Disease Neuroimaging Initiative, were used to capture high-dimensional gray matter atrophy in brain areas vulnerable to AD (e.g., amygdala, hippocampus, parahippocampal gyrus, thalamus, inferior temporal lobe areas, and midbrain). Using participants9 addresses...
1 CitationsSource
#1Andrew J. Petkus (SC: University of Southern California)H-Index: 16
#2Xinhui Wang (SC: University of Southern California)H-Index: 16
Last. Jiu-Chiuan Chen (SC: University of Southern California)H-Index: 32
view all 16 authors...
The interrelationships among long-term ambient air pollution exposure, emotional distress and cognitive decline in older adulthood remain unclear. Long-term exposure may impact cognitive performance and subsequently impact emotional health. Conversely, exposure may initially be associated with emotional distress followed by declines in cognitive performance. Here we tested the inter-relationship between global cognitive ability, emotional distress, and exposure to PM2.5 (particulate matter with ...
1 CitationsSource
#1Daniel E. Gustavson (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
view all 11 authors...
Despite the relevance of semantic fluency measures to risk for dementia and psychiatric disorders, little is known about their genetic and environmental architecture in mid-to-late life. Participants represent 21,684 middle-aged and older adult twins (M = 60.84 years, SD = 11.21; Range 40-89) from six studies from three countries participating in the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium. All completed the same measure of semantic fluency (naming animals i...
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#1Andrew J. Petkus (SC: University of Southern California)H-Index: 16
#2Diana Younan (SC: University of Southern California)H-Index: 7
Last. Jiu-Chiuan Chen (SC: University of Southern California)H-Index: 32
view all 15 authors...
Background/objectives Exposure to air pollution may contribute to both increasing depressive symptoms and decreasing episodic memory in older adulthood, but few studies have examined this hypothesis in a longitudinal context. Accordingly, we examined the association between air pollution and changes in depressive symptoms (DS) and episodic memory (EM) and their interrelationship in oldest-old (aged 80 and older) women. Design Prospective cohort data from the Women's Health Initiative Memory Stud...
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#1Ida K. Karlsson (KI: Karolinska Institutet)H-Index: 14
#2Yiqiang Zhan (KI: Karolinska Institutet)H-Index: 11
Last. Anna K. Dahl Aslan (KI: Karolinska Institutet)H-Index: 14
view all 5 authors...
Introduction To study if declining cognition drives weight loss in preclinical dementia, we examined the longitudinal association between body mass index (BMI) and cognitive abilities in individuals who did or did not later develop dementia. Methods Using data from individuals spanning age 50 to 89, we applied dual change score models separately in individuals who remained cognitively intact (n = 1498) and those who were diagnosed with dementia within 5 years of last assessment (n = 459). Result...
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