Ananya Choudhury
University of Manchester
CancerInternal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyMedical physicsCystectomyProstateChemotherapyHypoxia (medical)MEDLINEProstate cancerBladder cancerToxicityNuclear medicineMuscle invasiveRadiation therapyMedicine
288Publications
28H-index
2,721Citations
Publications 294
Newest
#1R. Shabbir (University of Manchester)
#2Marco Mingarelli (Aberd.: University of Aberdeen)H-Index: 6
Last. Tim A D Smith (University of Manchester)H-Index: 1
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Abstract null null Objective null Radioimmunotherapy (RIT) is a systemic therapy currently used in the treatment of patients with lymphoma. RIT complexes consist of a targeting molecule, commonly an antibody, radionuclide chelates and a linker which can be a nanoparticle platform. Nanoparticles facilitate the attachment of multiple radionuclides and targeting groups to a single complex. Here the target affinity, duration of target association and inhibition of colony formation of Cetuximab-resis...
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#1Jim ZhongH-Index: 5
#2Finbar Slevin (North Manchester General Hospital)H-Index: 1
Last. Ann HenryH-Index: 32
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#2Yee Pei Song (University of Manchester)H-Index: 4
Last. Ananya Choudhury (University of Manchester)H-Index: 28
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One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analy...
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#2A. Bajaj (NU: Northwestern University)
Last. Peter Hoskin (NU: Northwood University)H-Index: 94
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Abstract null null Bladder preservation with trimodality treatment (TMT) is an alternative strategy to radical cystectomy (RC) for the management of localised muscle invasive bladder cancer (MIBC). TMT comprises of transurethral resection of the bladder tumour (TURBT) followed by radiotherapy with concurrent radiosensitisation. TMT studies have shown neo-adjuvant chemotherapy with cisplatin-based regimens is often given to further improve survival outcomes. A hypofractionated radiotherapy regime...
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#1Sophie R. de Mol van Otterloo (UU: Utrecht University)H-Index: 1
Last. Corinne Faivre-Finn (University of Manchester)H-Index: 50
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ABSTRACT null null INTRODUCTION null : High-field MR-Linacs, linear accelerators (linac) combined with a diagnostic MRI scanner and online adaptive workflow, potentially give rise to novel online anatomic and response adaptive radiotherapy paradigms. Since the first high-field (1.5T) MR-Linac received regulatory approval in late 2018, little is known about clinical use, patient tolerability of daily high-field MRIs, and toxicity of treatments. Herein we report the initial experience within XXX (...
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#1B. Bibby (University of Manchester)H-Index: 2
#2N. Thiruthaneeswaran (USYD: University of Sydney)H-Index: 4
Last. Ananya Choudhury (University of Manchester)H-Index: 28
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BACKGROUND The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the therapeutic ratio. We aimed to investigate whether hypoxia-associated genes could be used to identify FDA approved drugs for repurposing for the treatment of hypoxic prostate cancer. METHODS Hypoxia associated genes were identified and used in the connectivity mapping software QUADrA...
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