Jörg Huwyler
University of Basel
PharmacokineticsBiophysicsInternal medicineReceptorLiposomeChemistryMaterials scienceIn vitroIn vivoBlood–brain barrierDrug deliveryDrugChemical engineeringChromatographyBiochemistryMedicineDosage formBiologyCell biologyPharmacology
205Publications
49H-index
7,251Citations
Publications 205
Newest
#1Dominik Witzigmann (University of Basel)H-Index: 16
#2Philip Grossen (University of Basel)H-Index: 8
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Abstract Hepatocellular carcinoma (HCC) is related to increasing incidence rates and poor clinical outcomes due to lack of efficient treatment options and emerging resistance mechanisms. The aim of the present study is to exploit a non-viral gene therapy enabling the expression of the parvovirus-derived oncotoxic protein NS1 in HCC. This anticancer protein interacts with different cellular kinases mediating a multimodal host-cell death. Lipoplexes (LPX) designed to deliver a DNA expression plasm...
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#1Ariane Schröter (University of Basel)H-Index: 1
#2Hanns-Christian Mahler (Goethe University Frankfurt)H-Index: 31
Last. Michael JahnH-Index: 2
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Abstract null null Introduction: The migration of chemicals from processing materials into biopharmaceuticals can lead to various problems. Leachables from administration materials, with no possibility of further clearance, are of particular concern. Released chemicals can be toxic or react with formulation components, thereby impacting product safety. Therapeutic proteins, which are susceptible to chemical modifications, have highest risk to be affected. null Aim: The aim of this study was to i...
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#1Ariane Schröter (University of Basel)H-Index: 1
#2Sonja Peter (ETH Zurich)
Last. Michael JahnH-Index: 2
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Abstract null null Leaching of toxic or reactive chemicals from polymeric materials can adversely affect the quality and safety of biopharmaceuticals. null It was therefore the aim of the present study to analyze leachables from a disposable clinical administration syringe using a polysorbate-containing surrogate solution and to assess their chemical reactivity. null Analytical methods did include (headspace) GC-MS, Fourier-transform-infrared spectroscopy, a ferrous oxidation-xylenol orange assa...
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Last. Huwyler J
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#1Daniel Preisig (University of Basel)H-Index: 4
#2Felipe J.O. VarumH-Index: 11
Last. Manuel Haschke (University Hospital of Basel)H-Index: 16
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Abstract Drug delivery to the colon offers great promise for local treatment of colonic diseases as it allows bypassing systemic absorption in the small intestine, thereby increasing luminal drug concentrations in the colon. The primary objective of this in vivo pharmaco-scintigraphy study was to assess the colon drug targeting accuracy of a metronidazole benzoate colonic drug delivery system intended for local treatment of Clostridioides difficile infections. Additionally, it was assessed if th...
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#1Viktoria Schreiner (University of Basel)H-Index: 1
#2Pascal Detampel (University of Basel)H-Index: 9
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Abstract Buprenorphine is a short-acting analgesic drug. Its use in veterinary medicine requires several injections per day to alleviate pain in animals. We, therefore, designed a poly-lactic-co-glycolic acid (PLGA) based depot formulation of the opioid to prolong the analgesic effect. We characterized our novel microparticulate depot formulation with emphasis on a potential future product development in the present work. Microparticles showed low residual moisture levels and did meet bacterial ...
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Abstract Advanced therapy medicinal products (ATMPs), such as somatic cell-therapy medicinal products or tissue-engineered products for human use, offer new and potentially curative opportunities to treat yet untreatable diseases or disorders. For cell-therapy medicinal products (CBMPs), multiple stability and quality challenges exist and relate to the cellular composition and unstable nature of these parenteral preparations. It is the aim of this review to discuss open questions and problems as...
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#1Anna Pratsinis (University of Basel)
#2Philipp Uhl (University Hospital Heidelberg)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the sodium taurocholate cotransporting polypeptide (NTCP) on the basolateral membrane of hepatocytes. Here, the feasibility of coupling therapeutic enzymes to MyrB was investigated for the development of enzyme delivery strategies. Hepatotropic targeting shall enable enzyme prodrug therapies and detox...
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There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-soluble depolymerized chitosan (dCS; MW 6–9 kDa) and low molecular weight polyethylenimine (PEI; 2.5 kDa linear, 1.8 kDa branched). dCS-PEI derivatives were evaluated based on their physicochemical properties, including purity, covalent bonding, solu...
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#2Jan Stephan BoltenH-Index: 1
Last. Bert MüllerH-Index: 50
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