Jian Wu
Zhejiang University
GeneMachine learningEndocrinologyGenomeMolecular biologyPattern recognitionChemistryImmunologyInformation retrievalPressure overloadFibrosisBrassica rapaComputer visionComputer scienceCancer researchDigital libraryGeneticsMedicineBiologyCell biology
Publications 1096
#1Junru ChenH-Index: 4
#2Chaofeng DingH-Index: 11
Last. Shusen ZhengH-Index: 46
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Lipid metabolic reprogramming plays a pivotal role in hepatocellular carcinoma (HCC) development, but the underlying mechanisms are incompletely characterized. Long chain acyl CoA synthetase 4 (ACSL4), a member of acyl-CoA synthetases (ACS) family, has been identified as a novel marker of alpha-fetoprotein-high subtype HCC and as an oncogene. Here, we identified a new function of ACSL4 in HCC lipid metabolism. ACSL4 can modulate de novo lipogenesis by accumulating intracellular triglycerides, ch...
#1Hui-Yan Li (Fudan University)H-Index: 2
#2Fangfei Yin (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Jian Wu (Fudan University)H-Index: 41
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Abstract The high expression of sonic hedgehog ligand (SHh) is closely correlated to the metastasis, drug resistance and poor prognosis of hepatocellular carcinoma (HCC). Therefore, sensitive, specific and efficient detection methods for SHh are needed for the early diagnosis and assessment of prognosis. Herein, an aptamer, AP32 that specifically binds to SHh (KD = 25.7 ± 4.1 nM) was obtained by SELEX technology with further optimization. In vivo experiments confirmed that AP32 has the potential...
1 CitationsSource
#1Hui Wu (ZJU: Zhejiang University)H-Index: 7
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Abstract CRISPR/Cas system is now playing an important role in biosensing applications, especially when the trans cleavage activity of several Cas effectors is discovered. Recently, CRISPR/Cas system combining with multiple detection techniques has been developed for various targets detection, which broadens the application scope of CRISPR/Cas system and makes the system more mature. In this review, the characteristics of four commonly used Cas effectors are first analyzed. Detection strategies ...
#1Zheng Cao (ZJU: Zhejiang University)
#2Wenzhe Wang (ZJU: Zhejiang University)
Last. Honghao Gao (Gachon University)
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Abstract Optic neuropathy is kind of common eye diseases, which usually causes irreversible vision loss. Early diagnosis is key to saving patients’ vision. Due to the similar early clinical manifestations of common optic neuropathy, it may cause misdiagnosis and delays in treatment. Worse, most diagnoses rely on experienced doctors. In this paper, we proposed a novel deep learning architecture GroupFusionNet (GFN) to diagnose five normal optic neuropathy diseases, including Anterior Ischemic Opt...
#1Pan Gu (China Jiliang University)H-Index: 1
#2Han Yuqiang (ZJU: Zhejiang University)H-Index: 1
Last. Jian Wu (ZJU: Zhejiang University)H-Index: 76
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Abstract Recommender systems are designed to help users find matching items from plenty of candidates in online platforms. In many online platforms, such as Yelp and Epinions, users’ behaviors are constantly recorded over time, and the users also can build connections with others and share their interests. Previous recommendation methods have either modeled the dynamic interests or the dynamic social influences. A few studies have focused on the modeling of both factors, but they still have seve...
2 CitationsSource
#1Rui Wang (Fudan University)
#2Rui Chen (Fudan University)H-Index: 1
Last. Fuyou Li (Fudan University)H-Index: 91
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Abstract Rapid and sensitive nucleic acid detection is critical for point-of-care testing (POCT). Here, we proposed an ultrasensitive visual nucleic acid detection method that could be accomplished in
1 CitationsSource
#1Ming-Bang Wu (ZJU: Zhejiang University)H-Index: 9
#2Sheng Huang (ZJU: Zhejiang University)H-Index: 3
Last. Zhi-Kang Xu (ZJU: Zhejiang University)H-Index: 61
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2 CitationsSource
#1Yuanxing ShenH-Index: 1
Last. Hui MaH-Index: 25
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Polarization imaging techniques are emerging tools to provide quantitative information of anisotropic structures, such as the density and orientation distribution of fibers in tissue samples. Recently, it is found that when using Mueller matrix polarimetry to obtain the structural features of tissue samples, some information can be revealed by relatively low-resolution polarization parameter images. Thus, to analyze what kinds of anisotropic optical and structural information contained in high-r...
#1Rong Chen (HAU: Hunan Agricultural University)H-Index: 1
#2Lichun ChangH-Index: 1
Last. Xiaowu WangH-Index: 4
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Abstract Brassica rapa is one of the most important leafy vegetable crops with large cultivated area in China. To increase the availability of DNA markers in B. rapa, we developed insertion-deletion (InDel) markers utilizing high-resolution melting (HRM) curve analysis. We designed primers for 252 InDels (≥ 3 bp) evenly distributed in the genome and tested gene polymorphisms with eight accessions. In total, 208 markers were specifically amplified, and 148 InDels with polymorphism were genotyped ...
1 CitationsSource
#1Xiang Wang (Fudan University)H-Index: 2
#2Y Z ZouH-Index: 1
Last. Hui GongH-Index: 20
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