Mark A. Farrow
University College London
Binding siteAntibodySmall moleculeNeuroscienceChemistryApoptosisProtein foldingIn vivoLong-term potentiationDiseaseNeurotoxicityPharmacological chaperoneHippocampal neuronAmyloid ßPrion proteinAmyloid precursor proteinAlzheimer's diseasePlasma protein bindingMonoclonal antibodyBiochemistryBioinformaticsComputational biologyDrug discoveryBiologyAmyloid
10Publications
7H-index
585Citations
Publications 13
Newest
#1E DemetriouH-Index: 1
#2M TachrountH-Index: 1
Last. Xavier GolayH-Index: 60
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In this work, we hypothesize that the metabolic changes occurring in the brain of prion-infected mice due to conformational changes of prion protein can be mapped using CEST MRI following previous in vivo work. Our previous findings include reduced Nuclear Overhauser Effect mediated by exchange-relayed signals in thalamus and cortex of prion-infected mice possibly related to up normal prion protein folding. Here we extend our studies by including a rich multipower acquisition scheme for targetin...
#1Silvia A. PurroH-Index: 4
#2Mark A. FarrowH-Index: 7
Last. John CollingeH-Index: 109
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We previously reported1 the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt–Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with prions. The marked deposition of parenchymal and vascular Aβ in these relatively young individuals with treatment-induced (iatrogenic) CJD (iCJD), in contrast to other prion-disease patients and population controls, allied with the ability of Alzheimer’s dis...
74 CitationsSource
#1Claire J. SarellH-Index: 2
#2Emma QuartermanH-Index: 2
Last. John CollingeH-Index: 109
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Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrPC). Ligands that bind ...
9 CitationsSource
#1E DemetriouH-Index: 1
#2M TachrountH-Index: 1
Last. X GolayH-Index: 1
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#1E DemetriouH-Index: 1
#2M TachrountH-Index: 1
Last. X GolayH-Index: 1
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1 Citations
#1Emmanuel Risse (UCL: University College London)H-Index: 2
#2Andrew J. Nicoll (UCL: University College London)H-Index: 14
Last. John Collinge (UCL: University College London)H-Index: 109
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The prion protein (PrP) has been implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular isoform (PrPC) is recruited into pathogenic self-propagating polymers of misfolded protein, and in Alzheimer disease, where PrPC may act as a receptor for synaptotoxic oligomeric forms of amyloid-β (Aβ). There has been considerable interest in identification of compounds that bind to PrPC, stabilizing its native fold and thereby acting as pharmacological chaperones t...
28 CitationsSource
#1E DemetriouH-Index: 1
Last. X GolayH-Index: 1
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#1Andrew J. Nicoll (UCL Institute of Neurology)H-Index: 14
#2Silvia Panico (Imperial College London)H-Index: 6
Last. John Collinge (UCL Institute of Neurology)H-Index: 109
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Prion protein has been suggested to bind toxic amyloid-s oligomers. Nicoll et al. demonstrate that binding to prion protein and prion protein-dependent synaptotoxicity correlate with the presence of a tubular form of amyloid-s with a defined triple helical structure.
96 CitationsSource
#1Michael FarmerH-Index: 7
#2P-C KloehnH-Index: 1
Last. John CollingeH-Index: 109
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42 Citations
#1Peter-Christian Klöhn (Medical Research Council)H-Index: 11
#2Michael Farmer (Medical Research Council)H-Index: 7
Last. John Collinge (Medical Research Council)H-Index: 109
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Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate therapeutics for prion and Alzheimer’s diseases. However, a previous report of severe and widespread apoptosis after intracerebral injection of anti-PrP monoclonal antibodies raised concerns about such therapy and led to an influential model of prion neurotoxicity via cross-linking of cel...
49 CitationsSource