Shan Fu
Hebei Medical University
AnalyteAnalytical chemistryDetection limitResponse surface methodologyMass spectrometryTime-of-flight mass spectrometryTriple quadrupole mass spectrometerIon suppression in liquid chromatography–mass spectrometryHigh-performance liquid chromatographyChemistryIon sourceElectrosprayCalibration curveAcetonitrileMetaboliteForced degradationLacosamideImperatorinAesculetinXanthotoxolAmmonium acetateQuadrupole ion trapAmpicillin SodiumAntiepileptic drugDry heatTandem mass spectrometryElectrospray ionizationChromatographyExtraction (chemistry)Selected reaction monitoringElutionHydrolysisQuantitative analysis (chemistry)Polarity (physics)
Publications 6
#1Na Zhou (Hebei Medical University)H-Index: 1
#2Tao Li (Hebei Medical University)H-Index: 4
Last. Qiao Wang (Hebei Medical University)H-Index: 19
view all 7 authors...
Lacosamide, a new type of antiepileptic drug, was subjected to forced degradation under the conditions of hydrolysis (acidic and alkaline), oxidation, dry heat, and photolysis to characterize its p...
1 CitationsSource
#1Minmin Zhao (Hebei Medical University)H-Index: 6
#2Weijing Ding (Hebei Medical University)H-Index: 6
Last. Qiao Wang (Hebei Medical University)H-Index: 19
view all 9 authors...
A rapid high-performance liquid chromatography coupled with tandem mass spectrometry method was developed for the simultaneous determination of five constituents in Qinpijiegu capsule (QJC), a classical Tibetan prescription. The separation of five compounds such as aesculin, aesculetin, fraxin, peimine and peiminine was performed on a Purospher STAR LP RP-C18 (250 3 4.6 mm, 5 mm) column with linear gradient elution of acetonitrile‐0.3‰ formic acid water in 13 min. Detection was carried out by mu...
6 CitationsSource
#1Shuang Wang (Hebei Medical University)H-Index: 5
#2Minmin Zhao (Hebei Medical University)H-Index: 6
Last. Qiao Wang (Hebei Medical University)H-Index: 19
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A novel sensitive and specific high-performance liquid chromatography‐tandem mass spectrometry method was established for the simultaneous determination of six constituents including geniposide, andrographolide, dehydroandrographolide, ophiopogonin D, methylophiopogonanone A and methylophiopogonanone B in Qing-huo-zhimai (QHZM) tablet, a well-known Chinese herbal preparation. The chromatographic separation was performed on a C18 column, and the mobile phasewas composed of 0.04% acetic acid and a...
#1Tao Li (Hebei Medical University)H-Index: 4
#2Xuanlin Xu (Shaanxi University of Chinese Medicine)H-Index: 1
Last. Qiao Wang (Hebei Medical University)H-Index: 19
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RATIONALE Clinical adverse reactions to ampicillin sodium are closely related to its impurities and degradation products. Several unknown degradation products have been detected in the degradation samples of ampicillin sodium. Therefore, a sensitive and accurate method is required to rapidly identify unknown degradation products. METHODS Ampicillin sodium was subjected to forced degradation under hydrolytic (acidic and alkaline), hot, photolytic, and humid stress conditions. A combination of liq...
10 CitationsSource
#1Shan Fu (Hebei Medical University)H-Index: 4
#2Juan Zhang (Hebei Medical University)H-Index: 4
Last. Jing JiaH-Index: 1
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Abstract A novel polarity switching high performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC–ESI-MS/MS) approach combining optimization of extraction condition by response surface methodology (RSM) was developed for the simultaneous quantitative analysis of 11 compounds in Cortex Fraxini, a commonly used traditional Chinese medicine. The ultrasonic extraction conditions of the 11 analytes including sample quantity, methanol concentration and extraction time w...
20 CitationsSource
#1Juan Zhang (Hebei Medical University)H-Index: 4
#2Min ZhangH-Index: 1
Last. Qiao Wang (Hebei Medical University)H-Index: 19
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Abstract The objective of the present study was to develop a new method for the simultaneous quantitation of imperatorin and its metabolite xanthotoxol in rat plasma. The samples were prepared with hollow fiber liquid phase microextraction (HF-LPME). The optimized extraction procedure was acquired by assessing extraction solvent, length of the fiber, agitation rate, extraction temperature and time. A comparison of sample pretreatment ways between HF-LPME and deproteinization with methanol was pe...
13 CitationsSource