Eleonora Cavallari
University of Turin
Substrate (chemistry)BiophysicsHyperpolarization (physics)Molecular imagingCatalysisNanotechnologyChemical reactionAqueous solutionChemistryMaterials scienceSpin isomers of hydrogenIn vitroIn vivoCombinatorial chemistryPyruvic acidLactate dehydrogenaseIron oxideSolventMetabolic imagingMoleculeChemical engineeringNuclear magnetic resonanceHydrogenBiochemistryMetabolismPhotochemistryInduced polarization
18Publications
12H-index
231Citations
Publications 21
Newest
#1Louise Rachel Tear (UNITO: University of Turin)H-Index: 1
#2Carla Carrera (National Research Council)H-Index: 14
Last. Eliana Gianolio (National Research Council)H-Index: 37
view all 8 authors...
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#1Oksana BondarH-Index: 1
#2Eleonora CavallariH-Index: 12
Last. Francesca Reineri (UNITO: University of Turin)H-Index: 21
view all 5 authors...
ParaHydrogen Induced Polarization-Side Arm Hydrogenation (PHIP-SAH) is an inexpensive tool to obtain hyperpolarized pyruvate (and other metabolites) that can be applied to in-vivo diagnostics, for the investigation of metabolic processes. This method is based on hydrogenation, using hydrogen enriched in the para-isomer, of unsaturated substrates, catalyzed, usually, by a homogeneous rhodium(I) complex. In this work, the effect of the solvent on the hydrogenation efficiency and on the hyperpolari...
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#1Carla Carrera (National Research Council)H-Index: 14
#2Eleonora Cavallari (UNITO: University of Turin)H-Index: 12
Last. Francesca Reineri (UNITO: University of Turin)H-Index: 21
view all 6 authors...
An efficient synthesis of vinyl-[1-13C]pyruvate has been reported, from which 13C hyperpolarized (HP) ethyl-[1-13C]pyruvate has been obtained by means of ParaHydrogen Induced Polarization (PHIP). Due to the intrinsic lability of pyruvate, which leads quickly to degradation of the reaction mixture even under mild reaction conditions, the vinyl-ester has been synthesized through the intermediacy of a more stable ketal derivative. 13C and 1H hyperpolarizations of ethyl-[1-13C]pyruvate, hydrogenated...
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Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization to attain sufficient signal strength. Dissolution dynamic nuclear polarization is the current state-of-the-art methodology for hyperpolarizing fumarate, but this is expensive and relatively slow. Alternatively, this important biomolecule can be hyperpolarized in a cheap and convenient manner using parahydrogen-induced polarizat...
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#1James Eills (University of Mainz)H-Index: 10
#2Eleonora Cavallari (UNITO: University of Turin)H-Index: 12
Last. Stephan KnechtH-Index: 12
view all 14 authors...
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#1James EillsH-Index: 10
#2Eleonora Cavallari (UNITO: University of Turin)H-Index: 12
Last. Stephan Knecht (Technische Universität Darmstadt)H-Index: 12
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Hyperpolarization-enhanced magnetic resonance imaging can be used to study biomolecular processes in the body, but typically requires nuclei such as 13 C, 15 N, or 129 Xe due to their long spin-polarization lifetimes and the absence of a proton-background signal from water and fat in the images. Here we present a novel type of 1 H imaging, in which hyperpolarized spin order is locked in a nonmagnetic long-lived correlated (singlet) state, and is only liberated for imaging by a specific biochemic...
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#1Francesca Reineri (UNITO: University of Turin)H-Index: 21
#2Eleonora Cavallari (UNITO: University of Turin)H-Index: 12
Last. Silvio Aime (UNITO: University of Turin)H-Index: 94
view all 4 authors...
ParaHydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, but its application to biological investigations has been hampered, so far, due to chemical challenges. PHIP is obtained by means of the addition of hydrogen, enriched in the para-spin isomer, to an unsaturated substrate. Both hydrogen atoms must be transferred to the same substrate, in a pairwise manner, by a suitable hydrogenation catalyst; therefore, a de-hydrogenated precursor of the target ...
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#1Matteo SorgeH-Index: 7
Last. Mara BrancaccioH-Index: 26
view all 19 authors...
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#1James EillsH-Index: 10
#2Eleonora CavallariH-Index: 12
Last. Francesca ReineriH-Index: 21
view all 14 authors...
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