Haralampos Hatzikirou
Khalifa University
PhysicsCancerStatistical physicsPhenotypeCell migrationCellBiological systemStochastic cellular automatonGliomaPopulationTumor growthMathematicsCellular automatonComputer scienceCancer researchCell growthMedicineMathematical modelBiologyImmune systemCell biology
86Publications
20H-index
1,603Citations
Publications 72
Newest
#1Pietro MascheroniH-Index: 7
#2Symeon V. Savvopoulos (Katholieke Universiteit Leuven)H-Index: 1
Last. Haralampos Hatzikirou (Khalifa University)H-Index: 20
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In clinical practice, a plethora of medical examinations are conducted to assess the state of a patient’s pathology producing a variety of clinical data. However, investigation of these data faces two major challenges. Firstly, we lack the knowledge of the mechanisms involved in regulating these data variables, and secondly, data collection is sparse in time since it relies on patient’s clinical presentation. The former limits the predictive accuracy of clinical outcomes for any mechanistic mode...
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#1Arnab BaruaH-Index: 2
#1Arnab Barua (TUD: Dresden University of Technology)H-Index: 1
Last. Haralampos HatzikirouH-Index: 20
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The way that progenitor cell fate decisions and the associated environmental sensing are regulated to ensure the robustness of the spatial and temporal order in which cells are generated towards a fully differentiating tissue still remains elusive. Here, we investigate how cells regulate their sensing intensity and radius to guarantee the required thermodynamic robustness of a differentiated tissue. In particular, we are interested in finding the conditions where dedifferentiation at cell level ...
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#1Arnab BaruaH-Index: 2
Last. Haralampos Hatzikirou (Khalifa University)H-Index: 20
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Collective migration is commonly observed in groups of migrating cells, in the form of swarms or aggregates. Mechanistic models have proven very useful in understanding collective cell migration. Such models, either explicitly consider the forces involved in the interaction and movement of individuals or phenomenologically define rules which mimic the observed behavior of cells. However, mechanisms leading to collective migration are varied and specific to the type of cells involved. Additionall...
4 CitationsSource
#1Arnab BaruaH-Index: 2
#2Simon SygaH-Index: 2
Last. Haralampos HatzikirouH-Index: 20
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This is an author-created, un-copyedited version of an article accepted for publication in the New Journal of Physics. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1367-2630/abcb2e.
3 CitationsSource
#1Arnab BaruaH-Index: 2
#2Simon SygaH-Index: 2
Last. Haralampos HatzikirouH-Index: 20
view all 8 authors...
#1Andreas DeutschH-Index: 36
#2Josué Manik Nava-Sedeño (UNAM: National Autonomous University of Mexico)
Last. Haralampos Hatzikirou (TUD: Dresden University of Technology)H-Index: 20
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1 Abstract Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective dynamics - understood as population behaviour arising from the interplay of the constituting discrete cells - can be studied with mathematical models. Off- and on-lattice agent-based models allow to analyse the link between individual cell and collective behaviour. Notably, in on-lattice agent-based models ...
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#1Ilaria Francesca Rizzuti (Hoffmann-La Roche)H-Index: 1
#2Pietro Mascheroni (BRICS)H-Index: 7
Last. Morgan Delarue (Hoffmann-La Roche)H-Index: 13
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While many cellular mechanisms leading to chemotherapeutic resistance have been identified, there is an increasing realization that tumor-stroma interactions also play an important role. In particular, mechanical alterations are inherent to solid cancer progression and profoundly impact cell physiology. Here, we explore the influence of compressive stress on the efficacy of chemotherapeutics in pancreatic cancer spheroids. We find that increased compressive stress leads to decreased drug efficac...
7 CitationsSource
#1J. M. Nava-Sedeño (TUD: Dresden University of Technology)H-Index: 3
#1Josué M. Nava-Sedeño (TUD: Dresden University of Technology)H-Index: 3
Last. Fernando Peruani (CNRS: Centre national de la recherche scientifique)H-Index: 28
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Biological processes, such as embryonic development, wound repair and cancer invasion, or bacterial swarming and fruiting body formation, involve collective motion of cells as a coordinated group. ...
2 CitationsSource
#1Pietro MascheroniH-Index: 7
Last. Haralampos HatzikirouH-Index: 20
view all 4 authors...
Biomedical problems are highly complex and multidimensional. Commonly, only a small subset of the relevant variables can be modeled by virtue of mathematical modeling due to lack of knowledge of the involved phenomena. Although, these models are effective in analyzing the approximate dynamics of the system, their predictive accuracy is generally limited. On the other hand, statistical learning methods are well-suited for quantitative reproduction of data, but they do not provide mechanistic unde...
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Summary Emerging evidence demonstrates that radiotherapy induces immunogenic death on tumor cells that emits immunostimulating signals resulting in tumor-specific immune responses. However, the impact of tumor features and microenvironmental factors on the efficacy of radiation-induced immunity remains to be elucidated. Herein, we use a calibrated model of tumor-effector cell interactions to investigate the potential benefits and immunological consequences of radiotherapy. Simulations analysis s...
3 CitationsSource