Yu-Hong Liu
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyProinflammatory cytokineTumor necrosis factor alphaChemistryApoptosisIn vivoSuperoxide dismutaseColitisOxidative stressInflammationPogostemonProstaglandin E2AntioxidantAnti-inflammatoryUlcerative colitisGlutathioneBiochemistryMedicineBiologyPharmacology
55Publications
19H-index
787Citations
Publications 57
Newest
#1Jingjing LiuH-Index: 4
#2Yulin Wu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Zi-Ren SuH-Index: 33
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#1Guoshu Lin (Guangzhou University of Chinese Medicine)H-Index: 1
#2Qiuxia Yu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 12 authors...
Abstract null null Phellodendri Chinensis Cortex (PC) is a traditional medicinal material used to treat gout and hyperuricemia (HUA) in China. Berberine (BBR), the main component of PC, possesses anti-hyperuricemic and anti-gout effects. However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption. Thus, the metabolites of BBR are believed to be the potential active forms responsible for its in vivo biological activities. Berberrubine (BRB), one of the major m...
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#1Jin-Fen Chen (Guangzhou University of Chinese Medicine)H-Index: 4
#2Lie-Qiang Xu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Cai JianH-Index: 4
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Sonneratia apetala seeds are considered as prospective nutraceuticals with a high content of unsaturated fatty acids (UFAs) which are mainly distributed in the oil. It is well-known that UFAs could exhibit urate-lowering potency and protect against renal injury, indicating that S. apetala seed oil (SSO) may possess hypouricemic and nephroprotective effects. Consequently, the present work attempted to probe into the effects and mechanisms of SSO on potassium oxonate/hypoxanthine-induced hyperuric...
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#1Jia-Zhen WuH-Index: 11
#2Yuxuan GanH-Index: 5
Last. Jian-Hui XieH-Index: 23
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Intestinal mucositis (IM) is the main side effect observed in patients who receive cancer chemotherapy. The characteristics of ulceration, vomiting, and severe diarrhea cause patients to delay or abandon further treatment, thereby aggravating their progress. Hence, IM cannot be overlooked. β-patchoulene (β-PAE) is an active ingredient isolated from Pogostemon cablin (Blanco) Benth. (Labiatae) and has shown a marked protective effect against gastrointestinal diseases in previous studies. However,...
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#1Huijuan Luo (Guangzhou University of Chinese Medicine)H-Index: 5
#2Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Zi-Ren Su (Guangzhou University of Chinese Medicine)H-Index: 33
view all 11 authors...
Non-alcoholic steatohepatitis (NASH), an extreme progressive subtype of metabolic associated fatty liver disease, is well characterized by hepatic steatosis, injury and inflammation. It causes irreversible hepatic damage and there are no approved interventions for it. β-PAE, a representatively pharmacological active substance isolated from Pogostemon cablin, has been indicated to alleviate hepatic steatosis and injury through modulating lipid metabolism in rats with simple steatosis. However, it...
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#1Lie-Qiang Xu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Qionghui Huang (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Ludi Fu (Guangzhou University of Chinese Medicine)H-Index: 1
view all 10 authors...
Abstract null null Alcoholism represents a predisposing factor for liver-related morbidity and mortality worldwide. Pogostemon cablin has been widely used in China for the treatment of digestive system diseases. Patchouli oil, the major active fraction of Pogostemon cablin, can ameliorate alcohol-induced acute liver injury (ALI). However, patchouli alcohol (PA), a principal bioactive ingredient of PO, exerts a protection against ALI remains elusive. The present work focused on the hepatoprotecti...
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#1Lie-Qiang Xu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Guoshu LinH-Index: 1
Last. Yu-Cui LiH-Index: 21
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Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation in vitro and in vivo. Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved in vivo efficacy on many metabolic disorders. However, its anti-hyperuricemia effect remains underexplored. In the present work, the hypouricemic and renoprotective ...
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#1Gaoxiang AiH-Index: 4
#2Zi-Wei HuangH-Index: 1
Last. Zi-Ren SuH-Index: 33
view all 10 authors...
Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute to its prominent bioactivities. To comparatively elucidate the protective effect and underlying mechanism of COP and its novel gut microbiota metabolite (8-oxocoptisine, OCOP) against colitis, we used dextran sulfate ...
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#1Qiao-Ping Li (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yao-Xing Dou (Guangzhou University of Chinese Medicine)H-Index: 10
Last. Jian-Hui Xie (Guangzhou University of Chinese Medicine)H-Index: 23
view all 12 authors...
Abstract Background : Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD). The metabolites of BBR were believed to contribute significantly to its pharmacological effects. Oxyberberine (OBB), a gut microbiota-mediated oxidative metabolite of BBR, has been firstly identified in our recent work. Purpose : Here, we aimed to comparatively investigate the anti-NAFLD properties of OBB and BBR. Methods : The anti-NAFLD effect was evaluated in high-fat diet-induced ob...
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#1Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 6
#2Huijuan Luo (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 12 authors...
Non-alcoholic fatty liver disease (NAFLD) has been a leading cause of chronic metabolic disease, seriously posing healthy burdens to the public, whereas interventions available for it are limited to date. Patchouli oil had been reported to attenuate hepatic steatosis in our previous study. β-patchoulene (β-PAE) is a representative component separated from patchouli oil with multiple activities, but its effect against NAFLD is still unknown. To investigate the effect and potential mechanism of β-...
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