Gilles Defraene
Katholieke Universiteit Leuven
OpticsCancerInternal medicineRadiologySurgeryMagnetic resonance imagingOncologyStage (cooking)Hounsfield scaleMaterials scienceMedical physicsPositron emission tomographyLung cancerMesotheliomaLungProstate cancerPopulationNuclear medicineNon small cellLung toxicityPleural mesotheliomaRadiation inducedRisk factorRadiation therapyBreast cancerMedicineDosimetryComplication
Publications 95
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
#1Nicola Rares Franco (Ghent University Hospital)
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
#1Ana M. Barragan-Montero (UCL: Université catholique de Louvain)H-Index: 2
#2Melissa Thomas (Katholieke Universiteit Leuven)H-Index: 5
Last. Edmond Sterpin (Katholieke Universiteit Leuven)H-Index: 20
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Abstract Purpose To investigate the effect of data quality and quantity on the performance of deep learning (DL) models, for dose prediction of intensity-modulated radiotherapy (IMRT) of esophageal cancer. Material and methods Two databases were used: a variable database (VarDB) with 56 clinical cases extracted retrospectively, including user-dependent variability in delineation and planning, different machines and beam configurations; and a homogenized database (HomDB), created to reduce this v...
4 CitationsSource
#1Melissa Thomas (Katholieke Universiteit Leuven)H-Index: 5
#2H.R. Mortensen (Aarhus University Hospital)H-Index: 6
Last. Karin Haustermans (Katholieke Universiteit Leuven)H-Index: 74
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Abstract Purpose To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer. Materials and methods Radiation oncologists of five European centres participated in the following consensus process: [1] revision of published (MEDLINE) and national/institutional delineation guidelines; [2] first delineation round of five cases (patient 1-5) according to national/institutional guidelines; [3] consensus meeting to discuss the results of step 1 and 2, follo...
3 CitationsSource
#1Dimitri Vanmarcke (Katholieke Universiteit Leuven)H-Index: 1
#2Johan Menten (Katholieke Universiteit Leuven)H-Index: 24
Last. Maarten Lambrecht (Katholieke Universiteit Leuven)H-Index: 18
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PURPOSE Patients with a benign meningioma often have a long survival following the treatment of their meningioma. Since radiotherapy is frequently part of the treatment, long-term side effects are of considerable concern. A controversial long-term side effect of radiotherapy is stroke. Due to its severity, it is important to know the frequency of this side effect. The aim of this study was to assess the stroke incidence and risk factors among patients receiving radiotherapy for their benign meni...
#1Melissa Thomas (Katholieke Universiteit Leuven)H-Index: 5
#2Robin De Roover (Katholieke Universiteit Leuven)H-Index: 5
Last. Karin Haustermans (Katholieke Universiteit Leuven)H-Index: 74
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Abstract Purpose To prospectively evaluate the feasibility of solid gold marker placement in oesophageal cancer patients and to quantify inter-fractional and intra-fractional (baseline shift) marker motion during radiation treatment. Radiotherapy target margins and matching strategies were investigated. Materials/Methods Thirty-four markers were implanted by echo-endoscopy in 10 patients. Patients received a planning 4D CT, daily pre-treatment cone-beam CT (CBCT) and a post-treatment CBCT for at...
#1Gilles Defraene (Katholieke Universiteit Leuven)H-Index: 12
#2Frank J. W. M. Dankers (Radboud University Nijmegen)H-Index: 8
Last. Dirk De Ruysscher (Katholieke Universiteit Leuven)H-Index: 83
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Abstract Background and purpose A higher radiation dose to the heart is known to be associated with increased mortality in non-small cell lung cancer (NSCLC) patients. It is however unknown what the contribution of the heart dose is when other risk factors for mortality are also accounted for. Materials and methods We constructed and externally validated prediction models of mortality after definitive chemoradiotherapy for NSCLC. Models were developed in 145 stage I-IIIB NSCLC patients. Clinical...
5 CitationsSource
#1Cédric DraulansH-Index: 6
#2Floris J. PosH-Index: 27
Last. Karin Haustermans (Katholieke Universiteit Leuven)H-Index: 74
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Abstract Purpose To assess the intermodality and intertracer variability of gallium-68 (68Ga)- or fluorine-18 (18F)-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET) and biparametric magnetic resonance imaging (bpMRI)-based gross tumor volume (GTV) delineation for focal boosting in primary prostate cancer. Methods Nineteen prospectively enrolled patients with prostate cancer underwent a PSMA PET/MRI scan, divided into a 1:1 ratio between 68Ga-PSMA-11 and 18F-PS...
1 CitationsSource
#1Tim Rattay (University of Leicester)H-Index: 9
#2Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
Last. Sheryl GreenH-Index: 18
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Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to develop predictive models for acute skin toxicity using published risk factors and externally validate the models in patients recruited into the prospective multi-center REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to red...
1 CitationsSource
Abstract While proton therapy offers an excellent dose conformity and sparing of organs at risk, this can be compromised by uncertainties, e.g. organ motion. This study aimed to investigate the influence of cardiac motion on the contoured oesophagus using electrocardiogram-triggered imaging and to assess the impact of this motion on the robustness of proton therapy plans in oesophageal cancer patients. Limited cardiac-induced motion of the oesophagus was observed with a negligible impact on the ...
#1P. Berkovic (Katholieke Universiteit Leuven)H-Index: 3
#1Patrick Berkovic (Katholieke Universiteit Leuven)H-Index: 1
Last. Gert De Meerleer (Katholieke Universiteit Leuven)H-Index: 36
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BACKGROUND: Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife(R)) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). Additionally we wanted to evaluate influence of tumor, patient and treatment related parameters on local control (LC), lung and distant progression free- (lung PFS/Di-PFS) and overall survival (OS). METHODS: Consecutive patients with up to 5 ORLM (confirmed by FDG PET/CT) were included in this study. Inten...
4 CitationsSource