Hui Nie
Guangzhou University
Internal medicineSynapseEndocrinologyCREBLipofuscinIn vitroImmunologyAutophagyLong-term potentiationNeuroprotectionSuperoxide dismutasePeptideHippocampusNeuronal apoptosisCortex (botany)Ca2+/calmodulin-dependent protein kinaseSignal transductionBiologyGap-43 proteinCell biology
Publications 2
#1Yunbo Chen (GU: Guangzhou University)H-Index: 3
#2Gang Wei (GU: Guangzhou University)H-Index: 3
Last. Dongfeng Chen (GU: Guangzhou University)H-Index: 22
view all 17 authors...
Abstract β-Asarone is an active component of the Acori graminei rhizome that is a traditional Chinese medicine clinically used in treating dementia in China. However, the cognitive effect of β-asarone and its mechanism has remained elusive. Here, we used asenescence-accelerated prone 8 (SAMP8) mice, which mimic many of the salient features of Alzheimer׳s disease (AD), to further investigate whether modulation of the ROCK signaling pathway and/or autophagy, synaptic loss is involved in the effect...
24 CitationsSource
#1Gang Wei (GU: Guangzhou University)H-Index: 3
#2Yunbo Chen (GU: Guangzhou University)H-Index: 3
Last. Hui Nie (GU: Guangzhou University)H-Index: 2
view all 13 authors...
Abstract β-Asarone, an active component of the Acori graminei rhizome that has been used as traditional Chinese herb, has been reported to be capable of inhibiting neuronal apoptosis. However, the signaling mechanism underlying the inhibitory effect of β-asarone has remained elusive. This study was aimed to investigate whether the CaMKII signaling pathway is involved in the β-asarone mediated neuroprotection. Using PC12 cells and primary cultures of cortical neurons treated with amyloid-β (Aβ)(1...
38 CitationsSource